{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T09:33:06Z","timestamp":1772357586795,"version":"3.50.1"},"reference-count":0,"publisher":"Hematology Section, Dept. of Radiological Science and Hematology, Catholic University, Rome, Italy","issue":"1","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediterr J Hematol Infect Dis"],"abstract":"<jats:p>Background: Eltrombopag (ELT) is an established thrombopoietin receptor agonist (TPO-RA) for chronic ITP, yet accumulating translational evidence indicates clinically relevant iron-chelating activity. Adult primary ITP\u2013focused data characterizing longitudinal iron trajectories during ELT remain limited. We assessed whether ELT exposure is independently associated with iron deficiency (ID) in routine practice.\nMethods: In this multicenter retrospective study, adults with ITP were evaluated with longitudinal monitoring of platelet count, ferritin, Tsat, Hb, and MPV. Within-patient change was defined as baseline minus follow-up (\u0394). Outcomes were compared by ELT exposure and dose strata. Multivariable linear regression was used to identify independent determinants of \u0394-ferritin, adjusting for age, gender, relapse status, and IRT.\nResults: The cohort included 283 adults with ITP; 110 received ELT (median 25 months). ELT was associated with greater declines in ferritin and Tsat (p&lt;0.001), with a dose-graded effect across 25\u201375 mg and earlier iron depletion at higher dose intensity. In relapsed patients not receiving ELT, mean \u0394-ferritin was positive and did not differ by bleeding status. In multivariable linear regression, ELT was the dominant independent predictor of lower \u0394-ferritin (B\u2248\u221279.8 \u00b5g\/L, p&lt;0.001), whereas age, gender, and relapse were not significant; IRT attenuated ferritin decline among ELT-treated patients but did not negate the ELT effect.\nConclusion: ELT exposure was independently associated with ID, supporting a clinically meaningful ELT-related iron chelation phenotype in routine practice. Monitoring and timely correction of ID during ELT therapy may mitigate a modifiable contributor to fatigue during follow-up.<\/jats:p>","DOI":"10.4084\/mjhid.2026.027","type":"journal-article","created":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T07:55:43Z","timestamp":1772351743000},"source":"Crossref","is-referenced-by-count":0,"title":["CLINICAL IMPACT OF ELTROMBOPAG-ASSOCIATED IRON CHELATION IN ADULTS WITH IMMUNE THROMBOCYTOPENIA: A MULTICENTER REAL-WORLD STUDY"],"prefix":"10.4084","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6216-595X","authenticated-orcid":false,"given":"Ahmet","family":"Yigitbasi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5589-3000","authenticated-orcid":false,"given":"Elif Gulsum","family":"Umit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6923-1470","authenticated-orcid":false,"given":"Ufuk","family":"Demirci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5166-6716","authenticated-orcid":false,"given":"Guray","family":"Aygun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nese","family":"Varli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"Aksoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6297-9555","authenticated-orcid":false,"given":"Fehmi","family":"Hindilerden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2836-6162","authenticated-orcid":false,"given":"Emine","family":"Gulturk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9262-2883","authenticated-orcid":false,"given":"Eren Arslan","family":"Davulcu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2073-5405","authenticated-orcid":false,"given":"Ahmet Muzaffer","family":"Demir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2554","published-online":{"date-parts":[[2026,2,28]]},"container-title":["Mediterranean Journal of Hematology and Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/download\/6241\/4845","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/download\/6241\/4852","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/download\/6241\/4845","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T07:55:43Z","timestamp":1772351743000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/view\/6241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,28]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.4084\/mjhid.2026.027","relation":{},"ISSN":["2035-3006"],"issn-type":[{"value":"2035-3006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,28]]}}}