{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T17:30:39Z","timestamp":1793467839780,"version":"4.5.0"},"reference-count":0,"publisher":"Hematology Section, Dept. of Radiological Science and Hematology, Catholic University, Rome, Italy","issue":"1","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediterr J Hematol Infect Dis"],"abstract":"<jats:p>Background: The study aimed to compare the incidence and course of febrile neutropenia (FN) and factors affecting mortality in hematologic patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) with either fresh or cryopreserved grafts.\r\nMethods: The clinical data of 155 patients who underwent allo-HSCT at our hematology clinic between 2010 and 2023 were retrospectively analyzed. The incidence of bloodstream infection (BSI) and FN-related mortality were analyzed in these patients. Factors affecting FN-related mortality were examined using a Cox regression model.\r\nResults: A total of 143 patients who developed FN were included in the study. Ninety-eight patients underwent transplantation with fresh stem cells and 45 patients with cryopreserved stem cells. The duration of FN episodes was similar between groups (p = 0.077); however, the duration of deep neutropenia (neutrophils &lt; 100\/mm\u00b3) was significantly longer in the cryopreserved group (11.56 \u00b1 4.84 vs. 7.78 \u00b1 3.03; p &lt; 0.001). GNB infections and invasive fungal infections were more frequent in the cryopreserved group (p = 0.009 and p &lt; 0.001, respectively). In the Cox regression model, the most important determinants of FN-related mortality were duration of the FN episode (HR 1.18; 95% CI 0.99\u20131.41; p = 0.046) and higher hematopoietic cell transplantation comorbidity index (HCT-CI) score (score 1; p = 0.014 and score 2; p = 0.039).\r\nConclusions: This study demonstrated that irrespective of the graft type, prolonged FN duration and high HCT-CI score are the primary determinants of mortality. Therefore, clinical management of patients should also address these risk factors.<\/jats:p>","DOI":"10.4084\/mjhid.2026.032","type":"journal-article","created":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T07:39:16Z","timestamp":1772350756000},"page":"e2026032","source":"Crossref","is-referenced-by-count":0,"title":["EFFECT OF FRESH VERSUS CRYOPRESERVED GRAFTS ON FEBRILE NEUTROPENIA AND INFECTIONS IN ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION: FACTORS DETERMINING MORTALITY."],"prefix":"10.4084","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5129-2977","authenticated-orcid":false,"given":"Cumali","family":"Yal\u00e7\u0131n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3970-2344","authenticated-orcid":false,"given":"Bedrettin","family":"Orhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuba","family":"Ersal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1497-9251","authenticated-orcid":false,"given":"M\u00fcmin","family":"\u015eent\u00fcrk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0014-7398","authenticated-orcid":false,"given":"Vildan","family":"\u00d6zkocaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7530-1279","authenticated-orcid":false,"given":"Halis","family":"Akal\u0131n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9710-134X","authenticated-orcid":false,"given":"Fahir","family":"\u00d6zkalemka\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2554","published-online":{"date-parts":[[2026,2,28]]},"container-title":["Mediterranean Journal of Hematology and Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/download\/6159\/4841","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/download\/6159\/4853","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/download\/6159\/4841","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T16:58:58Z","timestamp":1793465938000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/view\/6159"}},"subtitle":["Fresh vs Frozen Grafts: Infection and Outcome"],"short-title":[],"issued":{"date-parts":[[2026,2,28]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.4084\/mjhid.2026.032","relation":{},"ISSN":["2035-3006"],"issn-type":[{"value":"2035-3006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,28]]}}}