{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:46:20Z","timestamp":1782823580817,"version":"3.54.5"},"reference-count":0,"publisher":"Hematology Section, Dept. of Radiological Science and Hematology, Catholic University, Rome, Italy","issue":"1","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediterr J Hematol Infect Dis"],"abstract":"<jats:p>Background. Increased serum ferritin is a frequent finding in adults with \u03b2-thalassemia trait (BTT). However, whether such an increase is associated with a proportional increase in iron stores is unclear.\nObjectives. We aimed to evaluate liver iron stores in a consecutive cohort of BTT with hyperferritinemia who underwent the assessment of liver iron concentration by magnetic resonance (LICMRI) for clinical purposes.\nMethods. Sixty-six BTT subjects with hyperferritinemia were studied. Clinical, biochemical and genetic evaluations were done to assess the cause of hyperferritinemia. \u00a0LICMRI was classified as: grade-1= &lt;3 mg\/g (normal\/mild); grade-2= &gt;3&lt;7 mg\/g (moderate); grade-3= &gt;7 (severe).\nResults. 80.3% showed normal\/mild (n=29, 43.9%) or moderate LICMRI (n=24, 36.4%), while 19.7% (n=13) showed values &gt;7 mg\/g. The latter had lower hemoglobin concentration (p=0.004) and higher transferrin saturation and ferritin compared to subjects with lower LICMRI (p&lt;0.001), while steatotic liver disease were more frequent in subjects with lower LICMRI grades (p=0.012). Liver cirrhosis was significantly more frequent in subjects with moderate\/severe than in those with lower LICMRI grades (p=0.001 and p=0.025, respectively). We found a higher frequency of HFE and non-HFE iron-related genotypes (risky genotypes) in LICMRI grades 2-3 compared to none in LICMRI grade 1 (p=0.003 and p&lt;0.0001, respectively). A regression analysis identified risky genotypes, liver cirrhosis and BMI as significantly associated with LICMRI.\nConclusions. Hyperferritinemia is common in BTT subjects, but major iron overload is limited to a minority of cases. They present associated genetic and acquired causes of iron accumulation, and increased risk of liver damage.<\/jats:p>","DOI":"10.4084\/mjhid.2026.051","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:04:46Z","timestamp":1782821086000},"page":"e2026051","source":"Crossref","is-referenced-by-count":0,"title":["LIVER IRON CONTENT IN INDIVIDUALS WITH LIVER IRON CONTENT IN INDIVIDUALS WITH \u0392-THALASSEMIA TRAIT AND HYPERFERRITINEMIA: ROLE OF METABOLIC ALTERATIONS, HFE GENOTYPES, AND CIRRHOSIS.: ROLE OF METABOLIC ALTERATIONS, HFE GENOTYPES, AND CIRRHOSIS."],"prefix":"10.4084","volume":"18","author":[{"given":"Alberto","family":"Piperno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2554","published-online":{"date-parts":[[2026,6,30]]},"container-title":["Mediterranean Journal of Hematology and Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/download\/6295\/4922","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/download\/6295\/4923","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/download\/6295\/4929","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/download\/6295\/4922","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:04:46Z","timestamp":1782821086000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/view\/6295"}},"subtitle":["\u0392-THALASSEMIA TRAIT AND HYPERFERRITINEMIA"],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.4084\/mjhid.2026.051","relation":{},"ISSN":["2035-3006"],"issn-type":[{"value":"2035-3006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]}}}