{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T13:44:26Z","timestamp":1782827066538,"version":"3.54.5"},"reference-count":0,"publisher":"Hematology Section, Dept. of Radiological Science and Hematology, Catholic University, Rome, Italy","issue":"1","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediterr J Hematol Infect Dis"],"abstract":"<jats:p>Purpose\nThis study explores the impact of different immunoparesis states on early infection risk within six months of diagnosis in newly diagnosed multiple myeloma (MM) patients, aiming to inform clinical infection prevention strategies.\nMethodsA retrospective analysis was conducted on 213 newly diagnosed MM patients (2016-2024). Immunoparesis was classified qualitatively (no, partial, and full immunoparesis) and quantitatively (with immunoglobulin reduction &lt;50% and \u226550%). Early infection rates and immunoparesis status were assessed using Kaplan-Meier survival curves. Cox regression models were applied to evaluate the independent prognostic effect of immunoparesis on infection risk.\nResultsImmunoparesis significantly increased the risk of early infections. In the qualitative analysis, infection rates were 15.8% for no immunoparesis, 53.1% for partial, and 53.8% for full immunoparesis (Log-rank P = 0.017). In the quantitative analysis, infection rates were 51.9% for &lt;50% immunosuppression and 54.2% for \u226550% immunosuppression, compared to 15.8% for no immunoparesis(Log-rank P = 0.017). Cox regression analysis showed that partial and full immunoparesis increased infection risk by 8.9-fold (HR = 8.9, P = 0.004) and 7.8-fold (HR = 7.8, P = 0.006), respectively. Similarly, &lt;50% and \u226550% immunosuppression increased infection risk by 8.67-fold (HR = 8.67, P = 0.005) and 7.95-fold (HR = 7.95, P = 0.005), respectively.\nConclusionImmunoparesis significantly increases early infection risk in MM patients. However, the risk does not significantly rise with more immunoglobulin types suppressed or greater severity. Monitoring and timely intervention for immunoparesis are essential for infection prevention.<\/jats:p>","DOI":"10.4084\/mjhid.2026.062","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:51:07Z","timestamp":1782823867000},"page":"e2026062","source":"Crossref","is-referenced-by-count":0,"title":["IMPACT OF QUALITATIVE AND QUANTITATIVE IMMUNOPARESIS ON EARLY INFECTION RISK IN PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA"],"prefix":"10.4084","volume":"18","author":[{"given":"Hongfeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2554","published-online":{"date-parts":[[2026,6,30]]},"container-title":["Mediterranean Journal of Hematology and Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/download\/6275\/4921","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/download\/6275\/4928","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/download\/6275\/4921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:51:07Z","timestamp":1782823867000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/view\/6275"}},"subtitle":["Immunoparesis and early infection risk in myeloma"],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.4084\/mjhid.2026.062","relation":{},"ISSN":["2035-3006"],"issn-type":[{"value":"2035-3006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]}}}