{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T07:14:41Z","timestamp":1788333281046,"version":"build-2803163510"},"reference-count":0,"publisher":"Hematology Section, Dept. of Radiological Science and Hematology, Catholic University, Rome, Italy","issue":"1","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediterr J Hematol Infect Dis"],"abstract":"<jats:p>Objective:\u200b To investigate the association between baseline platelet count at diagnosis and complete remission (CR) rate, severe bleeding, and overall survival (OS) in newly diagnosed acute myeloid leukemia (AML).\nMethods: This single-center retrospective cohort study enrolled 356 non-acute promyelocytic leukemia (non-APL) AML patients treated with first-line therapy between January 2020 and December 2025. Patients were classified as having a low baseline platelet count (&lt;50 \u00d7 10\u2079\/L, n=218) or a normal\/high count (\u226550 \u00d7 10\u2079\/L, n=138). The primary outcomes were severe bleeding (CTCAE grade \u22653) and overall survival administratively censored at 24 months. Parsimonious multivariable Logistic and Cox models, Kaplan\u2013Meier analysis, 1:1 propensity score matching (PSM), continuous platelet modeling, restricted cubic splines (RCS), and alternative-threshold analyses were used.\nResults: CR (53.7% vs. 50.7%, P=0.665) and CR\/CRi rates (63.3% vs. 68.8%, P=0.339) did not differ significantly between groups. Severe bleeding was more frequent in the low-platelet group (22.5% vs. 8.7%, P=0.001), and low baseline platelet count remained associated with severe bleeding after parsimonious adjustment (OR=3.124, 95% CI 1.447\u20136.746, P=0.004). Kaplan\u2013Meier analysis showed lower 24-month OS in the low-platelet group (58.2% vs. 77.8%; log-rank P&lt;0.001), and the adjusted 24-month Cox model yielded an HR of 1.843 (95% CI 1.167\u20132.910, P=0.009). Per 10 \u00d7 10\u2079\/L higher baseline platelet count, the adjusted odds of severe bleeding were 24.2% lower and the 24-month death hazard was 11.4% lower. RCS analyses found no statistically significant departure from linearity. In the PSM sensitivity analysis, which retained residual covariate imbalance, the 24-month OS estimate remained significant (HR=1.981, 95% CI 1.228\u20133.193, P=0.005), whereas the severe-bleeding association was not confirmed (OR=2.286, 95% CI 0.940\u20135.556, P=0.068).\nConclusion: A baseline platelet count &lt;50 \u00d7 10\u2079\/L was associated with severe bleeding and lower 24-month OS, but not with induction CR, in this retrospective AML cohort. This study did not assess incremental predictive value beyond established AML risk systems; the findings should therefore be considered hypothesis-generating and require prospective external validation.<\/jats:p>","DOI":"10.4084\/mjhid.2026.071","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:37:49Z","timestamp":1788331069000},"page":"e2026071","source":"Crossref","is-referenced-by-count":0,"title":["ASSOCIATION OF BASELINE PLATELET COUNT WITH COMPLETE REMISSION, SEVERE BLEEDING, AND 24-MONTH OVERALL SURVIVAL IN PATIENTS WITH NEWLY DIAGNOSED ACUTE MYELOID LEUKEMIA: A SINGLE-CENTER RETROSPECTIVE COHORT STUDY"],"prefix":"10.4084","volume":"18","author":[{"given":"Tao","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengfeng","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5396-7397","authenticated-orcid":false,"given":"Yaping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2554","published-online":{"date-parts":[[2026,9,1]]},"container-title":["Mediterranean Journal of Hematology and Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/download\/6478\/4951","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/download\/6478\/4952","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/download\/6478\/4953","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/download\/6478\/4954","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/download\/6478\/4951","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:37:50Z","timestamp":1788331070000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/view\/6478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.4084\/mjhid.2026.071","relation":{},"ISSN":["2035-3006"],"issn-type":[{"value":"2035-3006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]}}}