{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T01:16:51Z","timestamp":1775092611737,"version":"3.50.1"},"reference-count":60,"publisher":"National Athletic Trainers' Association","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>A history of anterior cruciate ligament (ACL) injury and high body mass index (BMI) are strong risk factors for incident knee osteoarthritis (KOA). Limited research has evaluated the interaction between ACL injury and high BMI on early deleterious changes in cartilage health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine differences in T1\u03c1 relaxation time and serum cartilage oligomeric matrix protein (sCOMP) concentration between individuals with high and normal BMI following an ACL injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cross-sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>A controlled laboratory setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients or Other Participants<\/jats:title>\n                    <jats:p>\n                      Forty-two participants with primary ACL injuries were assigned to either the high-BMI (&gt;25 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , n = 20, age: 22.9 \u00b1 5.1 years, time between injury and visit: 3.6 \u00b1 2.2 weeks) or normal-BMI (\u226425 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , n = 22, age: 21.1 \u00b1 4.2 years, time between injury and visit: 3.3 \u00b1 1.7 weeks) group based on their BMI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measure(s)<\/jats:title>\n                    <jats:p>T1\u03c1 relaxation time for the medial and lateral tibia (MTC and LTC) and femur for each participant, sCOMP concentrations, and the Knee Injury and Osteoarthritis Outcome Score (KOOS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The high-BMI group, regardless of limbs, demonstrated greater T1\u03c1 relaxation times in the LTC (mean difference: 2.1 \u00b1 0.1 milliseconds,\n                      <jats:italic>P<\/jats:italic>\n                      = .004,\n                      <jats:italic>d<\/jats:italic>\n                      = 0.77) and MTC (mean difference: 1.7 \u00b1 0.4 milliseconds,\n                      <jats:italic>P<\/jats:italic>\n                      = .04,\n                      <jats:italic>d<\/jats:italic>\n                      = 0.44) knees compared with the normal-BMI group. The high-BMI group showed greater concentrations in sCOMP compared with the normal-BMI group (mean difference: 26.4 \u00b1 15.8 ng\/mL,\n                      <jats:italic>P<\/jats:italic>\n                      = .02,\n                      <jats:italic>d<\/jats:italic>\n                      = .72). There were no differences in KOOS scores between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overweight individuals experiencing primary ACL injuries exhibit higher T1\u03c1 relaxation times in both their injured and uninjured limbs and sCOMP concentrations compared with normal-weight individuals with primary ACL injuries. Our findings indicate that BMI significantly impacts cartilage composition and biochemical changes associated with KOA development in individuals with ACL injuries within 3.5 weeks of injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4085\/1062-6050-0027.25","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:31:16Z","timestamp":1775003476000},"page":"287-293","source":"Crossref","is-referenced-by-count":0,"title":["Body Mass Index Influences Tibiofemoral Cartilage Composition and Biochemistry in Individuals With Anterior Cruciate Ligament Injury"],"prefix":"10.4085","volume":"61","author":[{"given":"Hyunwook","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Sport, Health, and Rehabilitation, Kookmin University, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Zawel","sequence":"additional","affiliation":[{"name":"Department of Exercise and Sport Science, University of North Carolina at Chapel Hill"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew E.","family":"Dausch","sequence":"additional","affiliation":[{"name":"Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Lisee","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of Georgia, Athens"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Favoreto","sequence":"additional","affiliation":[{"name":"Department of Exercise and Sport Science, University of North Carolina at Chapel Hill"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Spang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, School of Medicine, University of North Carolina at Chapel Hill"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Lalush","sequence":"additional","affiliation":[{"name":"Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard F.","family":"Loeser","sequence":"additional","affiliation":[{"name":"Thurston Arthritis Research Center, University of North Carolina at Chapel Hill"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Pietrosimone","sequence":"additional","affiliation":[{"name":"Department of Exercise and Sport Science, University of North Carolina at Chapel Hill"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2557","reference":[{"issue":"1","key":"i1938-162X-61-4-287-b01","series-title":"J Orthop Surg Res","first-page":"634","article-title":"Evidence on risk factors for knee osteoarthritis in middle-older aged: a systematic review and meta analysis","volume":"18","author":"Dong","year":"2023","unstructured":"Dong Y,\nYan Y,\nZhou J,\nZhou Q,\nWei H. 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