{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:51:44Z","timestamp":1793663504376,"version":"4.5.1"},"reference-count":32,"publisher":"National Athletic Trainers' Association","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>The supplementary motor area (SMA) is involved in the functional deficits of chronic ankle instability (CAI), but the structural basis of its abnormalities remains unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To determine the differences in volume- and surface-based morphologic features of the SMA between patients with CAI and healthy controls and the relationship between these features and the clinical features of CAI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Cross-sectional study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Sports medicine laboratory.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients or Other Participants<\/jats:title>\n                  <jats:p>A total of 32 patients with CAI (10 women, 22 men; age = 32.46 \u00b1 7.51 years) and 31 healthy controls (12 women, 19 men; age = 29.70 \u00b1 8.07 years) participated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measure(s)<\/jats:title>\n                  <jats:p>We performed T1-weighted structural magnetic resonance imaging of participants and calculated volume- and surface-based morphologic features of SMA subregions. These subregions included anterior and posterior subdivisions of the medial portion of Brodmann area 6 (6 ma and 6 mp, respectively) and supplementary and cingulate eye fields. Between-group comparisons and correlation analysis with clinical features of CAI were performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Moderately thinner 6 mp (motor-output site; Cohen d = \u22120.61; 95% CI = \u22121.11, \u22120.10; P = .02) and moderately plainer 6 ma (motor-planning site; Cohen d = \u22120.70; 95% CI = \u22121.20, \u22120.19; P = .01) were observed in the CAI than the control group. A thinner 6 mp was correlated with lower Foot and Ankle Ability Measure Activities of Daily Living subscale scores before (r = 0.400, P = .02) and after (r = 0.449, P = .01) controlling for covariates.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Patients with CAI had a thinner 6 mp and a plainer 6 ma in the SMA compared with controls. The thin motor-output site of the SMA was associated with ankle dysfunction in patients. This morphologic evidence of maladaptive neuroplasticity in the SMA might promote more targeted rehabilitation of CAI.<\/jats:p>\n               <\/jats:sec>","DOI":"10.4085\/1062-6050-0257.23","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T12:09:29Z","timestamp":1701173369000},"page":"925-933","source":"Crossref","is-referenced-by-count":4,"title":["Thin and Plain Supplementary Motor Area in Chronic Ankle Instability: A Volume- and Surface-Based Morphometric Study"],"prefix":"10.4085","volume":"59","author":[{"given":"Xiao\u2019ao","family":"Xue","sequence":"first","affiliation":[{"name":"* Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"* Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China"},{"name":"\u2020 Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Yu","sequence":"additional","affiliation":[{"name":"\u2020 Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianru","family":"Li","sequence":"additional","affiliation":[{"name":"* Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Wang","sequence":"additional","affiliation":[{"name":"* Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Lu","sequence":"additional","affiliation":[{"name":"\u2021 Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 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