{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T22:33:08Z","timestamp":1791757988194,"version":"4.3.4"},"reference-count":33,"publisher":"National Athletic Trainers' Association","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Hypertrophy of the infrapatellar fat pad (IFP) in idiopathic knee osteoarthritis has been linked to deleterious synovial changes and joint pain related to mechanical tissue impingement. Yet little is known regarding the IFP's volumetric changes after anterior cruciate ligament reconstruction (ACLR).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To examine changes in IFP volume between 6 and 12 months after ACLR and determine associations between patient-reported outcomes and IFP volume at each time point as well as the volume change over time. In a subset of individuals, we examined interlimb IFP volume differences 12 months post-ACLR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Design<\/jats:title>\n                  <jats:p>Prospective cohort study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Laboratory.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients or Other Participants<\/jats:title>\n                  <jats:p>We studied 26 participants (13 women, 13 men, age = 21.88 \u00b1 3.58 years, body mass index = 23.82 \u00b1 2.21 kg\/m2) for our primary aims and 13 of those participants (8 women, 5 men, age = 21.15 \u00b1 3.85 years, body mass index = 23.01 \u00b1 2.01 kg\/m2) for our exploratory aim.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measure(s)<\/jats:title>\n                  <jats:p>Using magnetic resonance imaging, we evaluated the IFP volume change between 6 and 12 months post-ACLR in the ACLR limb and between-limbs differences at 12 months in a subset of participants. International Knee Documentation Committee subjective knee evaluation (IKDC) scores were collected at 6-month and 12-month follow-ups, and associations between IFP volume and patient-reported outcomes were determined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The IFP volume in the ACLR limb increased from 6 months (19.67 \u00b1 6.30 cm3) to 12 months (21.26 \u00b1 6.91 cm3) post-ACLR. Greater increases of IFP volume between 6 and 12 months were significantly associated with better 6-month IKDC scores (r = .44, P = .03). The IFP volume was greater in the uninjured limb (22.71 \u00b1 7.87 cm3) than in the ACLR limb (20.75 \u00b1 9.03 cm3) 12 months post-ACLR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The IFP volume increased between 6 and 12 months post-ACLR; however, the IFP volume of the ACLR limb remained smaller than that of the uninjured limb at 12 months. In addition, those with better knee function 6 months post-ACLR demonstrated greater increases in IFP volume between 6 and 12 months post-ACLR. This suggests that greater IFP volumes may play a role in long-term joint health after ACLR.<\/jats:p>\n               <\/jats:sec>","DOI":"10.4085\/1062-6050-0458.20","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T14:39:06Z","timestamp":1617201546000},"page":"1173-1179","source":"Crossref","is-referenced-by-count":11,"title":["Changes in Infrapatellar Fat Pad Volume 6 to 12 Months After Anterior Cruciate Ligament Reconstruction and Associations With Patient-Reported Knee Function"],"prefix":"10.4085","volume":"56","author":[{"given":"Kyle G.","family":"Wallace","sequence":"first","affiliation":[{"name":"Georgetown University School of Medicine, Washington, DC"},{"name":"MOTION Science Institute, Department of Exercise and Sport Science, University of North Carolina at Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"MOTION Science Institute, Department of Exercise and Sport Science, University of North Carolina at Chapel Hill"},{"name":"Ohio Musculoskeletal and Neurological Institute (OMNI), Ohio University, Athens"},{"name":"School of Applied Health Sciences and Wellness, Ohio University, Athens"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura S.","family":"Pietrosimone","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, School of Medicine, Duke University, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S.","family":"Harkey","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, Michigan State University, East Lansing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopeng","family":"Zong","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of North Carolina at Chapel Hill"},{"name":"Biomedical Research Imaging Center, School of Medicine, University of North Carolina at Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Nissman","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of North Carolina at Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh M.","family":"Kamath","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of North Carolina at Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Alexander","family":"Creighton","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of North Carolina at Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey T.","family":"Spang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of North Carolina at Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Troy","family":"Blackburn","sequence":"additional","affiliation":[{"name":"MOTION Science Institute, Department of Exercise and Sport Science, University of North Carolina at Chapel Hill"},{"name":"Department of Orthopaedics, University of North Carolina at Chapel Hill"},{"name":"Human Movement Science Curriculum, University of North Carolina at Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Pietrosimone","sequence":"additional","affiliation":[{"name":"MOTION Science Institute, Department of Exercise and Sport Science, University of North Carolina at Chapel Hill"},{"name":"Department of Orthopaedics, University of North Carolina at Chapel Hill"},{"name":"Human Movement Science Curriculum, University of North Carolina at Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2557","published-online":{"date-parts":[[2021,3,31]]},"reference":[{"key":"2021110920054411200_i1062-6050-56-11-1173-b01","doi-asserted-by":"crossref","unstructured":"Luc\n              B,\n            \n            \n              Gribble\n              PA,\n            \n            \n              Pietrosimone\n              BG.\n            \n          \n          Osteoarthritis prevalence following anterior cruciate ligament reconstruction: a systematic review and numbers-needed-to-treat analysis.\n\t\t\t\t\tJ Athl Train.\n\t\t\t\t\t2014;\n\t\t\t\t\t49(6):\n\t\t\t\t\t806\u2013\n\t\t\t\t\t819.\n\t\t\t\t\tdoi:10.4085\/1062-6050-49.3.35","DOI":"10.4085\/1062-6050-49.3.35"},{"key":"2021110920054411200_i1062-6050-56-11-1173-b02","doi-asserted-by":"crossref","unstructured":"Loeser\n              RF,\n            \n            \n              Goldring\n              SR,\n            \n            \n              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PH,\n            \n            \n              Siow\n              TY,\n            \n            et al.\n          \n          Change in T2* relaxation time of Hoffa fat pad correlates with histologic change in a rat anterior cruciate ligament transection model.\n\t\t\t\t\tJ Orthop Res.\n\t\t\t\t\t2015;\n\t\t\t\t\t33(9):\n\t\t\t\t\t1348\u2013\n\t\t\t\t\t1355.\n\t\t\t\t\tdoi:10.1002\/jor.22914","DOI":"10.1002\/jor.22914"},{"key":"2021110920054411200_i1062-6050-56-11-1173-b14","doi-asserted-by":"crossref","unstructured":"Solbak\n              NM,\n            \n            \n              Heard\n              BJ,\n            \n            \n              Achari\n              Y,\n            \n            et al.\n          \n          Alterations in Hoffa's fat pad induced by an inflammatory response following idealized anterior cruciate ligament surgery.\n\t\t\t\t\tInflamm 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Arthroscopic resection of fat pad lesions and infrapatellar contractures.\n\t\t\t\t\tArthrosc Tech.\n\t\t\t\t\t2014;\n\t\t\t\t\t3(3):\n\t\t\t\t\te413\u2013\n\t\t\t\t\te416.\n\t\t\t\t\tdoi:10.1016\/j.eats.2014.04.002","DOI":"10.1016\/j.eats.2014.04.002"},{"key":"2021110920054411200_i1062-6050-56-11-1173-b31","doi-asserted-by":"crossref","unstructured":"Teichtahl\n              AJ,\n            \n            \n              Wulidasari\n              E,\n            \n            \n              Brady\n              SR,\n            \n            et al.\n          \n          A large infrapatellar fat pad protects against knee pain and lateral tibial cartilage volume loss.\n\t\t\t\t\tArthritis Res Ther.\n\t\t\t\t\t2015;\n\t\t\t\t\t17(1):\n\t\t\t\t\t318.\n\t\t\t\t\tdoi:10.1186\/s13075-015-0831-y","DOI":"10.1186\/s13075-015-0831-y"},{"key":"2021110920054411200_i1062-6050-56-11-1173-b32","doi-asserted-by":"crossref","unstructured":"Heilmeier\n              U,\n            \n            \n    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