{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:30:15Z","timestamp":1793118615991,"version":"4.5.0"},"reference-count":28,"publisher":"National Athletic Trainers' Association","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>People with chronic ankle instability (CAI) display a lower regional and global health-related quality of life (HRQoL). Examinations of HRQoL outcomes associated with CAI have addressed younger adults, restricting our understanding of the long-term consequences of CAI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To compare ankle regional and global HRQoL in middle-aged participants with and those without CAI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Cross-sectional study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Laboratory.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients or Other Participants<\/jats:title>\n                  <jats:p>A total of 59 middle-aged volunteers, consisting of 18 with CAI (age = 50.2 \u00b1 9.3 years), 17 who were ankle-sprain copers (age = 54.5 \u00b1 8.7 years), and 24 uninjured controls (age = 56.7 \u00b1 10.0 years).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measure(s)<\/jats:title>\n                  <jats:p>Participants completed the Foot and Ankle Disability Index (FADI) and the Patient-Reported Outcomes Measurement Information System Adult Profile. Regional HRQoL was assessed using the FADI Activities of Daily Living and Sport subscales. Global HRQoL was measured using the 43-item Patient-Reported Outcomes Measurement Information System Adult Profile, which contains 7 short forms\u2014Physical Function, Pain Interference, Fatigue, Depression, Sleep Disturbance, Anxiety, and Ability to Participate in Social Roles and Activities. Separate Kruskal-Wallis tests were used to determine between-groups differences.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Middle-aged participants with CAI had lower scores on both subscales of the FADI than the coper and control groups (all P values &amp;lt;.001). Participants with CAI scored lower on the Physical Function (U = 116.0, z = \u22122.78, P = .005) and Ability to Participate in Social Roles and Activities (U = 96.0, z = \u22123.09, P = .002) subscales but higher on the Pain Interference (U = 144.0, z = \u22122.36, P = .02), Fatigue (U = 110.0, z = \u22122.72, P = .006), and Depression (U = 110.5, z = \u22122.91, P = .004) subscales than the control group. Participants with CAI also scored lower on the Physical Function (U = 74.5, z = \u22122.79, P = .005) and Ability to Participate in Social Roles and Activities (U = 55.0, z = \u22123.29, P = .001) subscales but higher on the Fatigue (U = 90.0, z = \u22122.09, P = .04) and Depression (U = 96.5, z = \u22121.97, P = .048) subscales than the coper group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Middle-aged participants with CAI displayed worse ankle regional and global HRQoL than their age-matched healthy counterparts and copers. These results demonstrated that CAI can affect HRQoL outcomes in middle-aged adults.<\/jats:p>\n               <\/jats:sec>","DOI":"10.4085\/1062-6050-190-19","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T20:46:41Z","timestamp":1590007601000},"page":"733-738","source":"Crossref","is-referenced-by-count":29,"title":["Health-Related Quality of Life Among Middle-Aged Adults With Chronic Ankle Instability, Copers, and Uninjured Controls"],"prefix":"10.4085","volume":"55","author":[{"given":"Kyle B.","family":"Kosik","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Sciences, University of Kentucky, Lexington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan F.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, University of Kentucky, Lexington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Terada","sequence":"additional","affiliation":[{"name":"Department of Sport and Health Science, Ritsumeikan University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbey C.","family":"Thomas-Fenwick","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, The University of North Carolina at Charlotte"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl G.","family":"Mattacola","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, University of Kentucky, Lexington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip A.","family":"Gribble","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, University of Kentucky, Lexington"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2557","published-online":{"date-parts":[[2020,5,20]]},"reference":[{"key":"2020072313161930100_i1062-6050-55-7-733-b01","doi-asserted-by":"crossref","unstructured":"Parsons\n              JT,\n            \n            \n              Snyder\n              AR.\n            \n          \n          Health-related quality of life as a primary clinical outcome in sport rehabilitation.\n\t\t\t\t\tJ Sport Rehabil.\n\t\t\t\t\t2011;\n\t\t\t\t\t20(1):\n\t\t\t\t\t17\u2013\n\t\t\t\t\t36.","DOI":"10.1123\/jsr.20.1.17"},{"key":"2020072313161930100_i1062-6050-55-7-733-b02","doi-asserted-by":"crossref","unstructured":"Deyo\n              RA.\n            \n          \n          Using outcomes to improve quality of research and quality of care.\n\t\t\t\t\tJ Am Board Fam 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