{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:51:42Z","timestamp":1793663502479,"version":"4.5.1"},"reference-count":48,"publisher":"National Athletic Trainers' Association","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Neuromuscular deficits are common in people with chronic ankle instability (CAI). Corticomotor pathways are very influential in the production of voluntary muscle function, yet these pathways have not been evaluated in people with CAI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To determine if corticomotor excitability of the fibularis longus (FL) differs between individuals with unilateral CAI and matched control participants without CAI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Case-control study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Laboratory.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients or Other Participants<\/jats:title>\n                  <jats:p>Ten people with CAI (4 men, 6 women; age = 21.2 \u00b1 1.23 years, height = 175.13 \u00b1 9.7 cm, mass = 77.1 \u00b1 13.58 kg) and 10 people without CAI (4 men, 6 women; age = 21.2 \u00b1 2.3 years; height = 172.34 \u00b1 8.86 cm, mass = 73.4 \u00b1 7.15 kg) volunteered for this study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measure(s)<\/jats:title>\n                  <jats:p>Transcranial magnetic stimulation was performed over the motor cortex on neurons corresponding with the FL. All testing was performed with the participant in a seated position with a slightly flexed knee joint and the ankle secured in 10\u00b0 of plantar flexion. The resting motor threshold (RMT), which was expressed as a percentage of 2 T, was considered the lowest amount of magnetic energy that would induce an FL motor evoked potential equal to or greater than 20 \u03bcV, as measured with surface electromyography, on 7 consecutive stimuli. In addition, the Functional Ankle Disability Index (FADI) and FADI Sport were used to assess self-reported function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Higher RMTs were found in the injured and uninjured FL of the CAI group (60.8% \u00b1 8.4% and 59.1% \u00b1 8.99%, respectively) than the healthy group (52.8% \u00b1 8.56% and 52% \u00b1 7.0%, respectively; F1,18 = 4.92, P = .04). No leg \u00d7 group interactions (F1,18 = 0.1, P = .76) or between-legs differences (F1,18 = 0.74, P = .40) were found. A moderate negative correlation was found between RMT and FADI (r = \u22120.4, P = .04) and FADI Sport (r = \u22120.44, P = .03), suggesting that higher RMT is related to lower self-reported function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Higher bilateral RMTs may indicate deficits in FL corticomotor excitability in people with CAI. In addition, a moderate correlation between RMT and FADI suggests that cortical excitability deficits may be influential in altering function.<\/jats:p>\n               <\/jats:sec>","DOI":"10.4085\/1062-6050-47.6.11","type":"journal-article","created":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T18:32:34Z","timestamp":1369074754000},"page":"621-626","source":"Crossref","is-referenced-by-count":117,"title":["Chronic Ankle Instability and Corticomotor Excitability of the Fibularis Longus Muscle"],"prefix":"10.4085","volume":"47","author":[{"given":"Brian G.","family":"Pietrosimone","sequence":"first","affiliation":[{"name":"Musculoskeletal Health and Movement Science Laboratory, University of Toledo, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip A.","family":"Gribble","sequence":"first","affiliation":[{"name":"Musculoskeletal Health and Movement Science Laboratory, University of Toledo, 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Statistical Concepts: A Second Course for Education and Behavioral Sciences"},{"issue":"6","key":"2020060411084554400_i1062-6050-47-6-621-b35","doi-asserted-by":"crossref","first-page":"570","DOI":"10.4085\/1062-6050-45.6.570","article-title":"Transcranial magnetic stimulation and volitional quadriceps activation","volume":"45","author":"Gibbons","year":"2010","journal-title":"J Athl Train"},{"issue":"2","key":"2020060411084554400_i1062-6050-47-6-621-b36","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/mus.20353","article-title":"Effect of transcranial magnetic stimulation on voluntary activation in patients with quadriceps weakness","volume":"32","author":"Urbach","year":"2005","journal-title":"Muscle Nerve"},{"issue":"3","key":"2020060411084554400_i1062-6050-47-6-621-b37","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1519\/JSC.0b013e318225ff75","article-title":"Effects of electromyographic biofeedback on quadriceps strength: a systematic review","volume":"26","author":"Lepley","year":"2012","journal-title":"J Strength Cond Res"},{"issue":"8","key":"2020060411084554400_i1062-6050-47-6-621-b38","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1136\/bjsm.2010.077404","article-title":"Characteristics of people with recurrent ankle sprains: a systematic review with meta-analysis","volume":"45","author":"Hiller","year":"2011","journal-title":"Br J Sports Med"},{"issue":"2","key":"2020060411084554400_i1062-6050-47-6-621-b39","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1519\/JSC.0b013e31818efbb2","article-title":"An examination of ankle, knee, and hip torque production in individuals with chronic ankle instability","volume":"23","author":"Gribble","year":"2009","journal-title":"J Strength Cond Res"},{"issue":"6","key":"2020060411084554400_i1062-6050-47-6-621-b40","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.jelekin.2004.06.002","article-title":"Arthrogenic muscle response induced by an experimental knee joint effusion is mediated by pre- and post-synaptic spinal mechanisms","volume":"14","author":"Palmieri","year":"2004","journal-title":"J Electromyogr Kinesiol"},{"issue":"3","key":"2020060411084554400_i1062-6050-47-6-621-b41","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1177\/0888439004269030","article-title":"Differential corticomotor control of a muscle adjacent to a painful joint","volume":"18","author":"On","year":"2004","journal-title":"Neurorehabil Neural Repair"},{"issue":"4","key":"2020060411084554400_i1062-6050-47-6-621-b42","doi-asserted-by":"crossref","first-page":"350","DOI":"10.4085\/1062-6050-44.4.350","article-title":"Alterations in knee kinematics and dynamic stability associated with chronic ankle instability","volume":"44","author":"Gribble","year":"2009","journal-title":"J Athl Train"},{"key":"2020060411084554400_i1062-6050-47-6-621-b43","unstructured":"Kandel\n              ER, \n            \n              Schwartz\n              JH, \n            \n              Jessell\n              TM. \n          \n          Principles of Neural Science. 3rd ed. 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