{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:12:10Z","timestamp":1761919930009,"version":"3.41.0"},"reference-count":37,"publisher":"National Athletic Trainers' Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3,1]]},"abstract":"<jats:sec><jats:title>Context:<\/jats:title><jats:p>The effect of ibuprofen on pain tolerance during exercise is controversial, and its effects on endurance performance have been poorly investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective:<\/jats:title><jats:p>To investigate the effect of prophylactic administration of the nonsteroidal anti-inflammatory drug ibuprofen on the time until the self-report of fatigue (tlim) in runners with exercise-induced muscle damage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design:<\/jats:title><jats:p>Randomized controlled clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting:<\/jats:title><jats:p>Laboratory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients or Other Participants:<\/jats:title><jats:p>Twenty healthy male long-distance runners (age = 18.8 \u00b1 0.4 years, maximal oxygen consumption = 55.5 \u00b1 5.9 mL\u00b7kg\u22121\u00b7min\u22121).<\/jats:p><\/jats:sec><jats:sec><jats:title>Intervention(s):<\/jats:title><jats:p>Participants were assigned to 2 groups (ibuprofen group = 10, placebo group = 10) to perform tlim trials (speed corresponded to their previously determined secondventilatory thresholds) 48 hours before and 48 hours after the induction of a lower limb muscle-damage protocol (isokinetic dynamometry). One hour before the second tlim trial, the ibuprofen group received 1.2 g ibuprofen, and the placebo group received lactose orally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measure(s):<\/jats:title><jats:p>Time until self-reported fatigue, heart rate, respiratory quotient, oxygen consumption, and perceived exertion were recorded during each tlim test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Both groups reported increases in muscle pain in the knee extensors and flexors 48 hours after the muscle-damage protocol. We observed a reduction in the endurance performance of both groups (P &amp;lt; .01) but no difference between groups (P = .55).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Ibuprofen did not reduce the effect of muscle damage and pain on performance. Prophylactic use of nonsteroidal anti-inflammatory drugs did not have an ergogenic effect on running performance after exercise-induced muscle damage in male long-distance runners.<\/jats:p><\/jats:sec>","DOI":"10.4085\/1062-6050-49.5.04","type":"journal-article","created":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T19:24:14Z","timestamp":1422300254000},"page":"295-302","source":"Crossref","is-referenced-by-count":16,"title":["Nonsteroidal Anti-Inflammatory Drug Use and Endurance During Running in Male Long-Distance Runners"],"prefix":"10.4085","volume":"50","author":[{"given":"Eduardo","family":"Da Silva","sequence":"first","affiliation":[{"name":"Unilasalle, Canoas, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronei S.","family":"Pinto","sequence":"first","affiliation":[{"name":"Exercise Research Laboratory, Federal University of Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo 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