{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T09:25:57Z","timestamp":1782552357228,"version":"3.54.5"},"reference-count":37,"publisher":"National Athletic Trainers' Association","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6,1]]},"abstract":"<jats:sec>\n                  <jats:title>Context:\u2003<\/jats:title>\n                  <jats:p>Ankle sprains remain the most common orthopaedic injury. Conducting long-term studies in humans is difficult and costly, so the long-term consequences of an ankle sprain are not entirely known.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective:\u2003<\/jats:title>\n                  <jats:p>To measure knee-joint space after a single surgically induced ankle sprain in mice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design:\u2003<\/jats:title>\n                  <jats:p>Randomized controlled trial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting:\u2003<\/jats:title>\n                  <jats:p>University research laboratory.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients or Other Participants:\u2003<\/jats:title>\n                  <jats:p>Thirty male mice (CBA\/2J) were randomly placed into 1 of 3 surgical groups: the transected calcaneofibular ligament (CFL) group, the transected anterior talofibular ligament\/CFL group, or a sham treatment group. The right ankle was operated on in all mice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measure(s):\u2003<\/jats:title>\n                  <jats:p>Three days after surgery, all of the mice were individually housed in cages containing a solid-surface running wheel, and daily running-wheel measurements were recorded. Before surgery and every 6 weeks after surgery, a diagnostic ultrasound was used to measure medial and lateral knee-joint space in both hind limbs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:\u2003<\/jats:title>\n                  <jats:p>Right medial (P = .003), right lateral (P = .002), left medial (P = .03), and left lateral (P = .002) knee-joint spaces decreased across the life span. The mice in the anterior talofibular ligament\/CFL group had decreased right medial (P = .004) joint space compared with the sham and CFL groups starting at 24 weeks of age and continuing throughout the life span. No differences occurred in contralateral knee-joint degeneration among any of the groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:\u2003<\/jats:title>\n                  <jats:p>Based on current data, mice that sustained a surgically induced severe ankle sprain developed greater joint degeneration in the ipsilateral knee. Knee degeneration could result from accommodation to the laxity of the ankle or biomechanical alterations secondary to ankle instability. A single surgically induced ankle sprain could significantly affect knee-joint function.<\/jats:p>\n               <\/jats:sec>","DOI":"10.4085\/1062-6050-52.3.07","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T18:09:12Z","timestamp":1493057352000},"page":"587-591","source":"Crossref","is-referenced-by-count":7,"title":["Acute Ankle Sprain in a Mouse Model: Changes in Knee-Joint Space"],"prefix":"10.4085","volume":"52","author":[{"given":"Tricia","family":"Hubbard-Turner","sequence":"first","affiliation":[{"name":"Department of Kinesiology, University of North Carolina at Charlotte;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik A.","family":"Wikstrom","sequence":"first","affiliation":[{"name":"Department of Exercise and Sport Science, University of North Carolina at Chapel Hill;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Guderian","sequence":"first","affiliation":[{"name":"University of Delaware, Newark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Turner","sequence":"first","affiliation":[{"name":"Department of Kinesiology, University of North Carolina at Charlotte;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2557","reference":[{"issue":"2","key":"2020060411400157500_i1062-6050-52-6-587-b01","first-page":"311","article-title":"Epidemiology of collegiate injuries for 15 sports: summary and recommendations for injury prevention initiatives","volume":"42","author":"Hootman","year":"2007","journal-title":"J Athl Train"},{"issue":"2","key":"2020060411400157500_i1062-6050-52-6-587-b02","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1136\/bjsm.35.2.103","article-title":"Ankle injuries in basketball: injury rate and risk factors","volume":"35","author":"McKay","year":"2001","journal-title":"Br J Sports Med"},{"issue":"10","key":"2020060411400157500_i1062-6050-52-6-587-b03","doi-asserted-by":"crossref","first-page":"852","DOI":"10.3113\/FAI.2012.0852","article-title":"The relationship between mechanical ankle joint laxity and subjective function","volume":"33","author":"Hubbard-Turner","year":"2012","journal-title":"Foot Ankle Int"},{"issue":"3","key":"2020060411400157500_i1062-6050-52-6-587-b04","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3113\/FAI.2008.0305","article-title":"Ligament laxity following inversion injury with and without chronic ankle instability","volume":"29","author":"Hubbard","year":"2008","journal-title":"Foot Ankle Int"},{"issue":"3","key":"2020060411400157500_i1062-6050-52-6-587-b05","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3113\/FAI.2007.0343","article-title":"Contributing factors to chronic ankle instability","volume":"28","author":"Hubbard","year":"2007","journal-title":"Foot Ankle Int"},{"issue":"3","key":"2020060411400157500_i1062-6050-52-6-587-b06","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2165\/00007256-200636030-00006","article-title":"Mechanical contributions to chronic lateral ankle instability","volume":"36","author":"Hubbard","year":"2006","journal-title":"Sports Med"},{"issue":"6","key":"2020060411400157500_i1062-6050-52-6-587-b07","doi-asserted-by":"crossref","first-page":"458","DOI":"10.2519\/jospt.2009.2989","article-title":"Self-assessed disability and functional performance in individuals with and without ankle instability: a case control study","volume":"39","author":"Wikstrom","year":"2009","journal-title":"J Orthop Sports Phys Ther"},{"issue":"6","key":"2020060411400157500_i1062-6050-52-6-587-b08","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1249\/MSS.0b013e318196cbc6","article-title":"Balance capabilities after lateral ankle trauma and intervention: a meta-analysis","volume":"41","author":"Wikstrom","year":"2009","journal-title":"Med Sci Sports Exerc"},{"issue":"4","key":"2020060411400157500_i1062-6050-52-6-587-b09","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.gaitpost.2010.02.004","article-title":"Bilateral balance impairments after lateral ankle trauma: a systematic review and meta-analysis","volume":"31","author":"Wikstrom","year":"2010","journal-title":"Gait Posture"},{"issue":"7","key":"2020060411400157500_i1062-6050-52-6-587-b10","doi-asserted-by":"crossref","first-page":"742","DOI":"10.4085\/1062-6050-50.3.05","article-title":"Physical activity levels in college students with chronic ankle instability","volume":"50","author":"Hubbard-Turner","year":"2015","journal-title":"J Athl Train"},{"key":"2020060411400157500_i1062-6050-52-6-587-b11","unstructured":"CDC injury research agenda: 2009\u20132018.Centers for Disease Control and Prevention Web site. https:\/\/stacks.cdc.gov\/view\/cdc\/21769. 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