{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:12:10Z","timestamp":1792019530126,"version":"4.4.0"},"reference-count":50,"publisher":"Korean Diabetes Association","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Medical and Healthy Technological Grant of Zhejiang Province","award":["2015KYB236"],"award-info":[{"award-number":["2015KYB236"]}]},{"name":"Medical and Healthy Technological Grant of Zhejiang Province","award":["2018KY769"],"award-info":[{"award-number":["2018KY769"]}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["81670767"],"award-info":[{"award-number":["81670767"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["81700732"],"award-info":[{"award-number":["81700732"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["synapse.koreamed.org"],"crossmark-restriction":false},"short-container-title":["Diabetes Metab J"],"published-print":{"date-parts":[[2020]]},"DOI":"10.4093\/dmj.2018.0235","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:22:17Z","timestamp":1572481337000},"page":"158","update-policy":"https:\/\/doi.org\/10.4093\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Fibroblast Growth Factor 21 Attenuates Diabetes-Induced Renal Fibrosis by Negatively Regulating TGF-\u03b2-p53-Smad2\/3-Mediated Epithelial-to-Mesenchymal Transition via Activation of AKT"],"prefix":"10.4093","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9640-061X","authenticated-orcid":false,"given":"Sundong","family":"Lin","sequence":"first","affiliation":[{"name":"Ruian Center of Chinese-American Research Institute for Diabetic Complications, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."},{"name":"Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China."},{"name":"School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0560-4028","authenticated-orcid":false,"given":"Lechu","family":"Yu","sequence":"additional","affiliation":[{"name":"Ruian Center of Chinese-American Research Institute for Diabetic Complications, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqing","family":"Ni","sequence":"additional","affiliation":[{"name":"Ruian Center of Chinese-American Research Institute for Diabetic Complications, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"He","sequence":"additional","affiliation":[{"name":"Ruian Center of Chinese-American Research Institute for Diabetic Complications, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."},{"name":"Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China."},{"name":"School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolu","family":"Weng","sequence":"additional","affiliation":[{"name":"Ruian Center of Chinese-American Research Institute for Diabetic Complications, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."},{"name":"Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2277-0052","authenticated-orcid":false,"given":"Xuemian","family":"Lu","sequence":"additional","affiliation":[{"name":"Ruian Center of Chinese-American Research Institute for Diabetic Complications, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3717-7665","authenticated-orcid":false,"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ruian Center of Chinese-American Research Institute for Diabetic Complications, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."},{"name":"Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China."},{"name":"School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2567","reference":[{"key":"10.4093\/dmj.2018.0235_ref1","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1172\/JCI72271","volume":"124","author":"Reidy","year":"2014","journal-title":"J Clin Invest"},{"key":"10.4093\/dmj.2018.0235_ref2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/dom.12630","volume":"18","author":"Gallagher","year":"2016","journal-title":"Diabetes Obes Metab"},{"key":"10.4093\/dmj.2018.0235_ref3","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.2337\/db16-1585","volume":"66","author":"Jha","year":"2017","journal-title":"Diabetes"},{"key":"10.4093\/dmj.2018.0235_ref4","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1096\/fj.201600382rr","volume":"31","author":"Pontrelli","year":"2017","journal-title":"FASEB J"},{"key":"10.4093\/dmj.2018.0235_ref5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/acel.12563","volume":"16","author":"Zhao","year":"2017","journal-title":"Aging Cell"},{"key":"10.4093\/dmj.2018.0235_ref6","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","volume":"139","author":"Thiery","year":"2009","journal-title":"Cell"},{"key":"10.4093\/dmj.2018.0235_ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cellsig.2017.11.005","volume":"43","author":"Higgins","year":"2018","journal-title":"Cell Signal"},{"key":"10.4093\/dmj.2018.0235_ref8","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jphs.2017.12.010","volume":"136","author":"Ma","year":"2018","journal-title":"J Pharmacol Sci"},{"key":"10.4093\/dmj.2018.0235_ref9","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.cell.2008.05.013","volume":"133","author":"Piccolo","year":"2008","journal-title":"Cell"},{"key":"10.4093\/dmj.2018.0235_ref10","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/s41419-018-0307-5","volume":"9","author":"Yang","year":"2018","journal-title":"Cell Death Dis"},{"key":"10.4093\/dmj.2018.0235_ref11","doi-asserted-by":"crossref","first-page":"e82275","DOI":"10.1371\/journal.pone.0082275","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS One"},{"key":"10.4093\/dmj.2018.0235_ref12","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1096\/fj.201701316R","volume":"32","author":"Li","year":"2018","journal-title":"FASEB J"},{"key":"10.4093\/dmj.2018.0235_ref13","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.yexcr.2016.06.020","volume":"346","author":"Wang","year":"2016","journal-title":"Exp Cell Res"},{"key":"10.4093\/dmj.2018.0235_ref14","first-page":"1762","volume":"5","author":"Zhang","year":"2015","journal-title":"Am J Cancer Res"},{"key":"10.4093\/dmj.2018.0235_ref15","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.jdiacomp.2018.05.012","volume":"32","author":"Guo","year":"2018","journal-title":"J Diabetes Complications"},{"key":"10.4093\/dmj.2018.0235_ref16","doi-asserted-by":"crossref","first-page":"e82287","DOI":"10.1371\/journal.pone.0082287","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS One"},{"key":"10.4093\/dmj.2018.0235_ref17","doi-asserted-by":"crossref","first-page":"E45","DOI":"10.1152\/ajpendo.00026.2015","volume":"309","author":"Shao","year":"2015","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.4093\/dmj.2018.0235_ref18","doi-asserted-by":"crossref","first-page":"e92574","DOI":"10.1371\/journal.pone.0092574","volume":"9","author":"Shao","year":"2014","journal-title":"PLoS One"},{"key":"10.4093\/dmj.2018.0235_ref19","doi-asserted-by":"crossref","first-page":"e49257","DOI":"10.1371\/journal.pone.0049257","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"key":"10.4093\/dmj.2018.0235_ref20","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.ejca.2013.12.027","volume":"50","author":"Gu","year":"2014","journal-title":"Eur J Cancer"},{"key":"10.4093\/dmj.2018.0235_ref21","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.yjmcc.2014.09.022","volume":"77","author":"Zhang","year":"2014","journal-title":"J Mol Cell Cardiol"},{"key":"10.4093\/dmj.2018.0235_ref22","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1210\/me.2015-1155","volume":"29","author":"Zhang","year":"2015","journal-title":"Mol Endocrinol"},{"key":"10.4093\/dmj.2018.0235_ref23","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.cca.2017.11.002","volume":"489","author":"Anuwatmatee","year":"2019","journal-title":"Clin Chim Acta"},{"key":"10.4093\/dmj.2018.0235_ref24","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1210\/jc.2014-3465","volume":"100","author":"Lee","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4093\/dmj.2018.0235_ref25","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/j.transproceed.2017.06.038","volume":"49","author":"Trakarnvanich","year":"2017","journal-title":"Transplant Proc"},{"key":"10.4093\/dmj.2018.0235_ref26","doi-asserted-by":"crossref","first-page":"79","DOI":"10.15171\/jrip.2016.17","volume":"5","author":"Bagheri","year":"2016","journal-title":"J Renal Inj Prev"},{"key":"10.4093\/dmj.2018.0235_ref27","doi-asserted-by":"crossref","first-page":"e0178971","DOI":"10.1371\/journal.pone.0178971","volume":"12","author":"Kohara","year":"2017","journal-title":"PLoS One"},{"key":"10.4093\/dmj.2018.0235_ref28","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s11845-017-1554-7","volume":"186","author":"Esteghamati","year":"2017","journal-title":"Ir J Med Sci"},{"key":"10.4093\/dmj.2018.0235_ref29","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1111\/cen.12380","volume":"80","author":"Hindricks","year":"2014","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.4093\/dmj.2018.0235_ref30","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1016\/j.metabol.2010.03.018","volume":"59","author":"Han","year":"2010","journal-title":"Metabolism"},{"key":"10.4093\/dmj.2018.0235_ref31","doi-asserted-by":"crossref","first-page":"532","DOI":"10.4103\/0366-6999.226065","volume":"131","author":"Shi","year":"2018","journal-title":"Chin Med J (Engl)"},{"key":"10.4093\/dmj.2018.0235_ref32","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1210\/en.2012-2276","volume":"154","author":"Kim","year":"2013","journal-title":"Endocrinology"},{"key":"10.4093\/dmj.2018.0235_ref33","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.2337\/db05-1435","volume":"55","author":"Wente","year":"2006","journal-title":"Diabetes"},{"key":"10.4093\/dmj.2018.0235_ref34","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","volume":"119","author":"Kalluri","year":"2009","journal-title":"J Clin Invest"},{"key":"10.4093\/dmj.2018.0235_ref35","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1172\/JCI39675","volume":"119","author":"Kalluri","year":"2009","journal-title":"J Clin Invest"},{"key":"10.4093\/dmj.2018.0235_ref36","doi-asserted-by":"crossref","first-page":"E4","DOI":"10.3390\/jcm5010004","volume":"5","author":"Tennakoon","year":"2015","journal-title":"J Clin Med"},{"key":"10.4093\/dmj.2018.0235_ref37","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1017\/S1462399410001481","volume":"12","author":"Burns","year":"2010","journal-title":"Expert Rev Mol Med"},{"key":"10.4093\/dmj.2018.0235_ref38","first-page":"2704","volume":"41","author":"Ling","year":"2018","journal-title":"Int J Mol Med"},{"key":"10.4093\/dmj.2018.0235_ref39","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1080\/0886022X.2017.1313164","volume":"39","author":"Ying","year":"2017","journal-title":"Ren Fail"},{"key":"10.4093\/dmj.2018.0235_ref40","first-page":"131","volume":"22","author":"Hills","year":"2011","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.4093\/dmj.2018.0235_ref41","doi-asserted-by":"crossref","first-page":"280","DOI":"10.2337\/db10-0892","volume":"60","author":"Wang","year":"2011","journal-title":"Diabetes"},{"key":"10.4093\/dmj.2018.0235_ref42","doi-asserted-by":"crossref","first-page":"8228","DOI":"10.1128\/MCB.00374-07","volume":"27","author":"Kalo","year":"2007","journal-title":"Mol Cell Biol"},{"key":"10.4093\/dmj.2018.0235_ref43","doi-asserted-by":"crossref","first-page":"35483","DOI":"10.1038\/srep35483","volume":"6","author":"Kawarada","year":"2016","journal-title":"Sci Rep"},{"key":"10.4093\/dmj.2018.0235_ref44","first-page":"4492","volume":"9","author":"Yan","year":"2017","journal-title":"Am J Transl Res"},{"key":"10.4093\/dmj.2018.0235_ref45","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1210\/en.2014-1619","volume":"156","author":"Jiang","year":"2015","journal-title":"Endocrinology"},{"key":"10.4093\/dmj.2018.0235_ref46","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1007\/s00125-017-4469-y","volume":"61","author":"Purvis","year":"2018","journal-title":"Diabetologia"},{"key":"10.4093\/dmj.2018.0235_ref47","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/jcmm.12239","volume":"18","author":"Li","year":"2014","journal-title":"J Cell Mol Med"},{"key":"10.4093\/dmj.2018.0235_ref48","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0968-0004(02)02166-7","volume":"27","author":"Mayo","year":"2002","journal-title":"Trends Biochem Sci"},{"key":"10.4093\/dmj.2018.0235_ref49","doi-asserted-by":"crossref","first-page":"38795","DOI":"10.1074\/jbc.M508578200","volume":"280","author":"Chi","year":"2005","journal-title":"J Biol Chem"},{"key":"10.4093\/dmj.2018.0235_ref50","first-page":"1001","volume":"1","author":"Moll","year":"2003","journal-title":"Mol Cancer Res"}],"container-title":["Diabetes & Metabolism Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/synapse.koreamed.org\/pdf\/10.4093\/dmj.2018.0235","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/synapse.koreamed.org\/DOIx.php?id=10.4093\/dmj.2018.0235","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-dmj.org\/upload\/pdf\/dmj-44-158.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T21:46:55Z","timestamp":1645739215000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-dmj.org\/journal\/view.php?doi=10.4093\/dmj.2018.0235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.4093\/dmj.2018.0235","relation":{},"ISSN":["2233-6079","2233-6087"],"issn-type":[{"value":"2233-6079","type":"print"},{"value":"2233-6087","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"https:\/\/synapse.koreamed.org\/DOIx.php?id=10.4093\/dmj.2018.0235","URL":"https:\/\/synapse.koreamed.org\/DOIx.php?id=10.4093\/dmj.2018.0235","name":"synapse","label":"Synapse","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"https:\/\/e-dmj.org\/DOIx.php?id=10.4093\/dmj.2018.0235","URL":"https:\/\/e-dmj.org\/DOIx.php?id=10.4093\/dmj.2018.0235","name":"the_journal","label":"the Journal","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"2018-11-15","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-02","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-28","name":"published_online","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"Copyright \u00a9 2020 Korean Diabetes Association","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}