{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:53:00Z","timestamp":1789645980414,"version":"4.0.0"},"reference-count":26,"publisher":"Korean Diabetes Association","issue":"1","license":[{"start":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:00:00Z","timestamp":1655683200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Boehringer Ingelheim Korea Ltd"}],"content-domain":{"domain":["e-dmj.org"],"crossmark-restriction":true},"short-container-title":["Diabetes Metab J"],"published-print":{"date-parts":[[2023,1,31]]},"abstract":"<jats:p>Background: To evaluate the safety and effectiveness of empagliflozin in routine clinical settings, we collected and assessed the clinical profiles of Korean patients with type 2 diabetes mellitus.Methods: This was a post-marketing surveillance study of empagliflozin 10 and 25 mg. Information on adverse events and adverse drug reactions (ADRs) was collected as safety data sets. Available effectiveness outcomes, including glycosylated hemoglobin (HbA1c) level, fasting plasma glucose, body weight, and blood pressure, were assessed.Results: The incidence rate of ADRs was 5.14% in the safety dataset (n=3,231). Pollakiuria, pruritis genital, and weight loss were the most common ADRs. ADRs of special interest accounted for only 1.18%, and there were no serious events that led to mortality or hospitalization. In the effectiveness data set (n=2,567), empagliflozin significantly reduced the mean HbA1c level and body weight during the study period by \u20130.68%\u00b11.39% and \u20131.91\u00b13.37 kg (both P&lt;0.0001), respectively. In addition, shorter disease duration, absence of dyslipidemia, and higher baseline HbA1c levels were identified as the clinical features characteristic of a \u201cresponder\u201d to empagliflozin therapy.Conclusion: Empagliflozin is a safe and potent glucose-lowering drug in routine use among Korean patients with type 2 diabetes mellitus. It is expected to have better glycemic efficacy in Korean patients with poorly controlled type 2 diabetes mellitus.<\/jats:p>","DOI":"10.4093\/dmj.2021.0356","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T07:52:56Z","timestamp":1655711576000},"page":"82-91","update-policy":"https:\/\/doi.org\/10.4093\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Safety and Effectiveness of Empagliflozin in Korean Patients with Type 2 Diabetes Mellitus: Results from a Nationwide Post-Marketing Surveillance"],"prefix":"10.4093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1569-3068","authenticated-orcid":true,"given":"Jun Sung","family":"Moon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Oh","family":"Na","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Hyoung","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Kyung","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Oh","family":"Mok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Jin","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhong","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Woo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Woo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5945-3395","authenticated-orcid":true,"given":"Kyu Chang","family":"Won","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2567","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2020.0254"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2011.35.4.303"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2011.10.029"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-022577"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2021.0156"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10122713"},{"key":"ref7","first-page":"417","volume-title":"Sodium-glucose cotransporter-2 inhibitors and the risk for diabetic ketoacidosis: a multicenter cohort study","author":"Douros","year":"2020"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13647"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-3167"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1504720"},{"key":"ref11","first-page":"e12843","volume-title":"Efficacy and safety of empagliflozin for type 2 diabetes mellitus: meta-analysis of randomized controlled trials","author":"Zhang","year":"2018"},{"key":"ref12","first-page":"2289","volume-title":"Sodium-glucose cotransporter-2 inhibitors for type 2 diabetes mellitus in adults: an overview of 46 systematic reviews","author":"Augusto","year":"2021"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-2419"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1515920"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02733-w"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-019-0674-7"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.03.027"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.7326\/m18-3136"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12868"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2019.0208"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-8587(16)00052-8"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-92925-2"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-018-0470-9"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1172\/jci72227"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1172\/jci70704"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3828"}],"container-title":["Diabetes &amp; 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