{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:47:41Z","timestamp":1791337661558,"version":"4.3.1"},"reference-count":37,"publisher":"Korean Diabetes Association","issue":"3","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003052","name":"Ministry of Trade, Industry and Energy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["RS-2022-00141116"],"award-info":[{"award-number":["RS-2022-00141116"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100021093","name":"Korean Endocrine Society","doi-asserted-by":"crossref","award":["2020-51-0390"],"award-info":[{"award-number":["2020-51-0390"]}],"id":[{"id":"10.13039\/100021093","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["e-dmj.org"],"crossmark-restriction":true},"short-container-title":["Diabetes Metab J"],"published-print":{"date-parts":[[2024,5,31]]},"abstract":"<jats:p>Background: This study investigated the optimal coefficient of variance (%CV) for preventing hypoglycemia based on real-time continuous glucose monitoring (rt-CGM) data in people with type 1 diabetes mellitus (T1DM) already achieving their mean glucose (MG) target.Methods: Data from 172 subjects who underwent rt-CGM for at least 90 days and for whom 439 90-day glycemic profiles were available were analyzed. Receiver operator characteristic analysis was conducted to determine the cut-off value of %CV to achieve time below range (%TBR)&lt;sup&gt;&lt;54 mg\/dL&lt;\/sup&gt; &lt;1 and =0.Results: Overall mean glycosylated hemoglobin was 6.8% and median %TBR&lt;sup&gt;&lt;54 mg\/dL&lt;\/sup&gt; was 0.2%. MG was significantly higher and %CV significantly lower in profiles achieving %TBR&lt;sup&gt;&lt;54 mg\/dL&lt;\/sup&gt; &lt;1 compared to %TBR&lt;sup&gt;&lt;54 mg\/dL&lt;\/sup&gt; \u22651 (all P&lt;0.001). The cut-off value of %CV for achieving %TBR&lt;sup&gt;&lt;54 mg\/dL&lt;\/sup&gt; &lt;1 was 37.5%, 37.3%, and 31.0%, in the whole population, MG &gt;135 mg\/dL, and \u2264135 mg\/dL, respectively. The cut-off value for %TBR&lt;sup&gt;&lt;54 mg\/dL&lt;\/sup&gt;=0% was 29.2% in MG \u2264135 mg\/dL. In profiles with MG \u2264135 mg\/dL, 94.2% of profiles with a %CV &lt;31 achieved the target of %TBR&lt;sup&gt;&lt;54 mg\/dL&lt;\/sup&gt; &lt;1, and 97.3% with a %CV &lt;29.2 achieved the target of %TBR&lt;54 mg\/ dL=0%. When MG was &gt;135 mg\/dL, 99.4% of profiles with a %CV &lt;37.3 achieved %TBR&lt;sup&gt;&lt;54 mg\/dL&lt;\/sup&gt; &lt;1.Conclusion: In well-controlled T1DM with MG \u2264135 mg\/dL, we suggest a %CV &lt;31% to achieve the %TBR&lt;sup&gt;&lt;54 mg\/dL&lt;\/sup&gt; &lt;1 target. Furthermore, we suggest a %CV &lt;29.2% to achieve the target of %TBR&lt;sup&gt;&lt;54 mg\/dL&lt;\/sup&gt; =0 for people at high risk of hypoglycemia.<\/jats:p>","DOI":"10.4093\/dmj.2023.0083","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T07:07:47Z","timestamp":1710313667000},"page":"429-439","update-policy":"https:\/\/doi.org\/10.4093\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Optimal Coefficient of Variance Threshold to Minimize Hypoglycemia Risk in Individuals with Well-Controlled Type 1 Diabetes Mellitus"],"prefix":"10.4093","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2536-6274","authenticated-orcid":true,"given":"Jee Hee","family":"Yoo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Hee","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Man","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5001-963X","authenticated-orcid":true,"given":"Jae Hyeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2567","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(09)61969-3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-1144"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199309303291401"},{"key":"ref4","first-page":"416","volume-title":"The legacy effect in type 2 diabetes: impact of early glycemic control on future complications (The Diabetes &amp; 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