{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:51:29Z","timestamp":1791996689046,"version":"4.4.0"},"reference-count":24,"publisher":"Korean Diabetes Association","issue":"4","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Diabetes Hongkong","award":["RF202201"],"award-info":[{"award-number":["RF202201"]}]},{"name":"Li Ka Shing Medical Fellowship for Internal Medicine"}],"content-domain":{"domain":["e-dmj.org"],"crossmark-restriction":true},"short-container-title":["Diabetes Metab J"],"published-print":{"date-parts":[[2024,7,31]]},"abstract":"<jats:p>Background: We evaluated changes in glycemic status, over 1 year, of coronavirus disease 2019 (COVID-19) survivors with dysglycemia in acute COVID-19.Methods: COVID-19 survivors who had dysglycemia (defined by glycosylated hemoglobin [HbA1c] 5.7% to 6.4% or random glucose \u226510.0 mmol\/L) in acute COVID-19 were recruited from a major COVID-19 treatment center from September to October 2020. Matched non-COVID controls were recruited from community. The 75-g oral glucose tolerance test (OGTT) were performed at baseline (6 weeks after acute COVID-19) and 1 year after acute COVID-19, with HbA1c, insulin and C-peptide measurements. Progression in glycemic status was defined by progression from normoglycemia to prediabetes\/diabetes, or prediabetes to diabetes.Results: Fifty-two COVID-19 survivors were recruited. Compared with non-COVID controls, they had higher C-peptide (P&lt; 0.001) and trend towards higher homeostasis model assessment of insulin resistance (P=0.065). Forty-three COVID-19 survivors attended 1-year reassessment. HbA1c increased from 5.5%\u00b10.3% to 5.7%\u00b10.2% (P&lt;0.001), with increases in glucose on OGTT at fasting (P=0.089), 30-minute (P=0.126), 1-hour (P=0.014), and 2-hour (P=0.165). At baseline, 19 subjects had normoglycemia, 23 had prediabetes, and one had diabetes. Over 1 year, 10 subjects (23.8%; of 42 non-diabetes subjects at baseline) had progression in glycemic status. C-peptide levels remained unchanged (P=0.835). Matsuda index decreased (P=0.007) and there was a trend of body mass index increase from 24.4\u00b12.7 kg\/m2 to 25.6\u00b15.2 (P=0.083). Subjects with progression in glycemic status had more severe COVID-19 illness than non-progressors (P=0.030). Reassessment was not performed in the control group.Conclusion: Subjects who had dysglycemia in acute COVID-19 were characterized by insulin resistance. Over 1 year, a quarter had progression in glycemic status, especially those with more severe COVID-19. Importantly, there was no significant deterioration in insulin secretory capacity.<\/jats:p>","DOI":"10.4093\/dmj.2023.0175","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:17:02Z","timestamp":1710202622000},"page":"763-770","update-policy":"https:\/\/doi.org\/10.4093\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Prospective 1-Year Follow-up of Glycemic Status and C-Peptide Levels of COVID-19 Survivors with Dysglycemia in Acute COVID-19 Infection"],"prefix":"10.4093","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9813-1126","authenticated-orcid":true,"given":"David Tak Wai","family":"Lui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol Ho Yi","family":"Fong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly Hang","family":"Tsoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Cho","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9037-0416","authenticated-orcid":true,"given":"Kathryn Choon Beng","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2567","reference":[{"key":"ref1","volume-title":"WHO coronavirus (COVID-19) dashboard"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00846-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-020-00662-x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/nejmc2018688"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-022-05833-z"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-1318"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02656-y"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-8587(22)00044-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-022-05670-0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3803\/enm.2023.1662"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-8587(21)00208-4"},{"key":"ref12","first-page":"570","volume-title":"Preserved C-peptide in survivors of COVID-19: post hoc analysis","author":"Clarke","year":"2022"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.eprac.2021.06.016"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa813"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2022.109232"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-1427"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.9.1462"},{"key":"ref18","first-page":"1785","volume-title":"COVID-19 associated ketosis and diabetic ketoacidosis: a rapid review","author":"Alamuri","year":"2023"},{"key":"ref19","first-page":"505","volume-title":"The time to offer treatments for COVID-19","author":"Ngo","year":"2021"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2299"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad284"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13644"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm8108"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27603"}],"container-title":["Diabetes &amp; Metabolism Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-dmj.org\/upload\/pdf\/dmj-2023-0175.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-dmj.org\/journal\/view.php?doi=10.4093\/dmj.2023.0175","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-dmj.org\/upload\/pdf\/dmj-2023-0175.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T23:34:04Z","timestamp":1722555244000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-dmj.org\/journal\/view.php?doi=10.4093\/dmj.2023.0175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,31]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"URL":"https:\/\/doi.org\/10.4093\/dmj.2023.0175","relation":{},"ISSN":["2233-6079","2233-6087"],"issn-type":[{"value":"2233-6079","type":"print"},{"value":"2233-6087","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,31]]},"assertion":[{"value":"2023-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-11","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-31","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}