{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:16:40Z","timestamp":1790680600326,"version":"4.1.0"},"reference-count":47,"publisher":"Korean Diabetes Association","issue":"2","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Unveiling and Leading Program of Hunan Province","award":["2021JC0003"],"award-info":[{"award-number":["2021JC0003"]}]},{"name":"Science and Technology Innovation Program of Hunan Province","award":["2020RC4044"],"award-info":[{"award-number":["2020RC4044"]}]},{"name":"Sinocare Diabetes Foundation","award":["2021SD06"],"award-info":[{"award-number":["2021SD06"]}]},{"name":"Sinocare Diabetes Foundation","award":["LYF2022039"],"award-info":[{"award-number":["LYF2022039"]}]}],"content-domain":{"domain":["e-dmj.org"],"crossmark-restriction":true},"short-container-title":["Diabetes Metab J"],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:p>Background: Automated insulin delivery (AID) systems studies are upsurging, half of which were published in the last 5 years. We aimed to evaluate the efficacy and safety of AID systems in patients with type 1 diabetes mellitus (T1DM).Methods: We searched PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov until August 31, 2023. Randomized clinical trials that compared AID systems with other insulin-based treatments in patients with T1DM were considered eligible. Studies characteristics and glycemic metrics was extracted by three researchers independently.Results: Sixty-five trials (3,623 patients) were included. The percentage of time in range (TIR) was 11.74% (95% confidence interval [CI], 9.37 to 14.12; &lt;i&gt;P&lt;\/i&gt;&lt;0.001) higher with AID systems compared with control treatments. Patients on AID systems had more pronounced improvement of time below range when diabetes duration was more than 20 years (\u20131.80% vs. \u20130.86%, &lt;i&gt;P&lt;\/i&gt;=0.031) and baseline glycosylated hemoglobin lower than 7.5% (\u20131.93% vs. \u20130.87%, &lt;i&gt;P&lt;\/i&gt;=0.033). Dual-hormone full closed-loop systems revealed a greater improvement in TIR compared with hybrid closed-loop systems (\u201319.64% vs. \u201310.87%). Notably, glycemia risk index (GRI) (\u20133.74; 95% CI, \u20136.34 to \u20131.14; &lt;i&gt;P&lt;\/i&gt;&lt;0.01) was also improved with AID therapy.Conclusion: AID systems showed significant advantages compared to other insulin-based treatments in improving glucose control represented by TIR and GRI in patients with T1DM, with more favorable effect in euglycemia by dual-hormone full closedloop systems as well as less hypoglycemia for patients who are within target for glycemic control and have longer diabetes duration.<\/jats:p>","DOI":"10.4093\/dmj.2024.0130","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T07:57:46Z","timestamp":1731484666000},"page":"235-251","update-policy":"https:\/\/doi.org\/10.4093\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Efficacy and Safety of Automated Insulin Delivery Systems in Patients with Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis"],"prefix":"10.4093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8241-3833","authenticated-orcid":true,"given":"Wenqi","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1994-949X","authenticated-orcid":true,"given":"Chao","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoyao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard 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