{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:16:28Z","timestamp":1792707388889,"version":"4.5.0"},"reference-count":88,"publisher":"Korean Diabetes Association","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023-00208709"],"award-info":[{"award-number":["RS-2023-00208709"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Institute for Information and communication Technology Planning and evaluation","award":["RS-2022-II220965"],"award-info":[{"award-number":["RS-2022-II220965"]}]}],"content-domain":{"domain":["e-dmj.org"],"crossmark-restriction":true},"short-container-title":["Diabetes Metab J"],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:p>Type 2 diabetes mellitus (T2DM) is marked by chronic hyperglycemia, gradually worsening \u03b2-cell failure, and insulin resistance. Glucotoxicity and oxidative stress cause \u03b2-cell failure by increasing reactive oxygen species (ROS) production, impairing insulin secretion, and disrupting transcription factors such as pancreatic and duodenal homeobox 1 (PDX-1) and musculoaponeurotic fibrosarcoma oncogene family A (MafA). Cluster determinant 36 (CD36), an essential glycoprotein responsible for fatty acid uptake, exacerbates oxidative stress and induces the apoptosis of \u03b2-cells under hyperglycemic conditions through pathways involving ceramide, thioredoxin-interacting protein (TXNIP), and Rac1-nicotinamide adenine dinucleotide phosphate oxidase (NOX)-mediated redoxosome formation. Targeting CD36 pathways has emerged as a promising therapeutic strategy. Oral hypoglycemic agents, such as metformin, teneligliptin, and pioglitazone, have shown protective effects on \u03b2-cells by enhancing antioxidant defenses. These agents reduce glucotoxicity via mechanisms such as suppressing CD36 expression and stabilizing mitochondrial function. Additionally, novel insights into the glutathione antioxidant system and its role in \u03b2-cell survival underscore its therapeutic potential. This review focuses on the key contribution of oxidative stress and CD36 to \u03b2-cell impairment, the therapeutic promise of antioxidants, and the need for further research to apply these findings in clinical practice. Promising strategies targeting these mechanisms may help preserve \u03b2-cell function and slow T2DM progression.<\/jats:p>","DOI":"10.4093\/dmj.2024.0796","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T02:25:39Z","timestamp":1736130339000},"page":"1-12","update-policy":"https:\/\/doi.org\/10.4093\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Overcoming \u03b2-Cell Dysfunction in Type 2 Diabetes Mellitus: CD36 Inhibition and Antioxidant System"],"prefix":"10.4093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4436-0158","authenticated-orcid":true,"given":"Il Rae","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6719-2150","authenticated-orcid":true,"given":"Yong 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