{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:21:34Z","timestamp":1787509294156,"version":"build-2736575974"},"reference-count":49,"publisher":"Korean Diabetes Association","issue":"2","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"SK Chem"},{"DOI":"10.13039\/100016275","name":"Seoul National University Bundang Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-dmj.org"],"crossmark-restriction":true},"short-container-title":["Diabetes Metab J"],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:p>Background: We conducted a prospective, randomized study to evaluate the combination of cilostazol (CTZ) and extract of &lt;i&gt;Ginkgo biloba&lt;\/i&gt; (EGb) and compare it with aspirin for the prevention of atherosclerosis progression in patients with type 2 diabetes mellitus (T2DM).Methods: One hundred five patients with T2DM and increased carotid intima-media thickness (IMT) were randomly assigned to receive either CTZ 200 mg plus EGb 160 mg once daily or aspirin (ASA) 100 mg\/day for 12 months. The primary endpoint was the change in maximum carotid IMT.Results: The mean age and body mass index were 61.6\u00b18.4 years and 25.2\u00b13.1 kg\/m&lt;sup&gt;2&lt;\/sup&gt; in the CTZ\/EGb group and 61.6\u00b17.6 years and 24.5\u00b13.3 kg\/m&lt;sup&gt;2&lt;\/sup&gt; in the ASA group, respectively. CTZ\/EGb treatment reduced the maximum IMT in the bulb area (from 1.435\u00b10.690 to 1.346\u00b10.688 mm on the right; from 1.359\u00b10.528 to 1.299\u00b10.528 mm on the left), whereas ASA treatment did not, resulting in significant between-group differences (P&lt;0.05). No significant differences were observed in the common carotid and internal carotid arteries. The CTZ\/EGb group showed a reduction in triglycerides and an increase in high-density lipoprotein cholesterol levels. Additionally, aspartate and alanine aminotransferase levels decreased only in the CTZ\/EGb group. There were no significant differences in Mini-Mental State Examination (MMSE) score changes or adverse events (ClinicalTrials.gov number: NCT05906199).Conclusion: Twelve months of CTZ\/EGb combination therapy significantly attenuated the progression of carotid atherosclerosis compared with aspirin in patients with T2DM.<\/jats:p>","DOI":"10.4093\/dmj.2025.0146","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T23:47:28Z","timestamp":1755128848000},"page":"357-367","update-policy":"https:\/\/doi.org\/10.4093\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of Efficacy and Safety of Cilostazol\/Extract of Ginkgo biloba vs. Aspirin in Carotid Atherosclerosis in Patients with Diabetes 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