{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T05:27:24Z","timestamp":1786685244768,"version":"build-2736575974"},"reference-count":30,"publisher":"Korean Diabetes Association","content-domain":{"domain":["e-dmj.org"],"crossmark-restriction":true},"short-container-title":["Diabetes Metab J"],"DOI":"10.4093\/dmj.2025.1152","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T07:27:36Z","timestamp":1785310056000},"update-policy":"https:\/\/doi.org\/10.4093\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of the Dual SGLT1 and SGLT2 Inhibitor JP-2266 in Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study"],"prefix":"10.4093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4968-5026","authenticated-orcid":true,"given":"Eun Young","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Ah","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Heon","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Hwa","family":"Hong","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, Daejeon Eulji Medical Center, Eulji University School of Medicine, Daejeon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Cheol","family":"Hwang","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwanpyo","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Jeju National University Hospital, Jeju National University College of Medicine, Jeju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing W.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Department of Medicine, Yale School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soomee","family":"Kim","sequence":"additional","affiliation":[{"name":"Global Business Division, Jeil Pharmaceutical Co. Ltd., Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Seok","family":"Lee","sequence":"additional","affiliation":[{"name":"Central Research Institute, Jeil Pharmaceutical Co. Ltd., Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0542-2854","authenticated-orcid":true,"given":"Bong-Soo","family":"Cha","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2567","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"ref1","first-page":"582","volume":"49","author":"Kang","year":"2025","journal-title":"2025 Clinical practice guidelines for diabetes management in Korea: recommendation of the Korean Diabetes Association"},{"key":"ref2","first-page":"S181","volume":"48","year":"2025","journal-title":"9. Pharmacologic approaches to glycemic treatment: standards of care in diabetes-2025"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1611925"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1504720"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1812389"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2019.1601404"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.06.017"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-019-0562-1"},{"key":"ref9","first-page":"43","volume":"21 Suppl 2","author":"Dominguez Rieg","year":"2019","journal-title":"What does sodium-glucose cotransporter 1 inhibition add: prospects for dual inhibition"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00286.2014"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.115.225508"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-2166"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz258"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1303694"},{"key":"ref15","first-page":"721","volume":"15","author":"Ferrannini","year":"2013","journal-title":"A phase IIb, randomized, placebo-controlled study of the SGLT2 inhibitor empagliflozin in patients with type 2 diabetes"},{"key":"ref16","first-page":"432","volume":"15","author":"Kaku","year":"2013","journal-title":"Efficacy and safety of dapagliflozin as a monotherapy for type 2 diabetes mellitus in Japanese patients with inadequate glycaemic control: a phase II multicentre, randomized, double-blind, placebo-controlled trial"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1863"},{"key":"ref18","first-page":"2237","volume":"34","author":"Cavalot","year":"2011","journal-title":"Postprandial blood glucose predicts cardiovascular events and all-cause mortality in type 2 diabetes in a 14-year follow-up: lessons from the San Luigi Gonzaga Diabetes Study"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.03.107"},{"key":"ref20","first-page":"187","volume":"61","author":"Gorboulev","year":"2012","journal-title":"Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2011.01517.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4654-7"},{"key":"ref23","first-page":"710","volume":"60","author":"Goodwin","year":"2017","journal-title":"Discovery of LX2761, a sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor restricted to the intestinal lumen, for the treatment of diabetes"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2012.59"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2017.11.016"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291x(91)92053-m"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2014.10.026"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105068"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.2337\/db18-0856"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2024.0036"}],"container-title":["Diabetes & Metabolism Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-dmj.org\/upload\/pdf\/dmj-2025-1152.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:45:05Z","timestamp":1786682705000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-dmj.org\/journal\/view.php?doi=10.4093\/dmj.2025.1152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,29]]},"references-count":30,"URL":"https:\/\/doi.org\/10.4093\/dmj.2025.1152","relation":{},"ISSN":["2233-6079","2233-6087"],"issn-type":[{"value":"2233-6079","type":"print"},{"value":"2233-6087","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,29]]},"assertion":[{"value":"2025-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-29","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}}]}}