{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:09:35Z","timestamp":1792253375725,"version":"4.4.0"},"reference-count":85,"publisher":"The Korean Society of Anesthesiologists","issue":"4","license":[{"start":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T00:00:00Z","timestamp":1561075200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ekja.org"],"crossmark-restriction":true},"short-container-title":["Korean J Anesthesiol"],"published-print":{"date-parts":[[2019,8,1]]},"DOI":"10.4097\/kja.19259","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T00:51:43Z","timestamp":1561078303000},"page":"323-330","update-policy":"https:\/\/doi.org\/10.4097\/crossmark_policy","source":"Crossref","is-referenced-by-count":335,"title":["Dexmedetomidine: present and future directions"],"prefix":"10.4097","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2675-2521","authenticated-orcid":true,"given":"Seongheon","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2573","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e328305e3ef"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181e74116"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2017.70.4.375"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000163476.42034.A1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199412000-00029"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200302000-00024"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200003000-00035"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200008000-00016"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-0770(03)00200-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/87.5.684"},{"key":"ref11","first-page":"153","volume-title":"Dexmedetomidine vs. propofol for short-term sedation of postoperative mechanically ventilated patients","author":"Elbaradie","year":"2004"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.2707"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198907000-00014"},{"key":"ref14","first-page":"941","volume-title":"The analgesic potency of dexmedetomidine is enhanced after nerve injury: a possible role for peripheral alpha2-adrenoceptors","author":"Poree","year":"1998"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(91)90111-A"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/68.2.126"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199108000-00002"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14657"},{"key":"ref19","first-page":"339","volume-title":"A Comparative study of intrathecal dexmedetomidine and fentanyl as adjuvants to Bupivacaine","author":"Gupta","year":"2011"},{"key":"ref20","first-page":"e93114","volume-title":"Does dexmedetomidine as a neuraxial adjuvant facilitate better anesthesia and analgesia? A systematic review and meta-analysis","author":"Wu","year":"2014"},{"key":"ref21","first-page":"118","volume-title":"The role of alpha-2 adrenoceptor subtype in the antiallodynic effect of intraplantar dexmedetomidine in a rat spinal nerve ligation model","author":"Lee","year":"2013"},{"key":"ref22","first-page":"e36344","volume-title":"The effect of pre-emptive dexmedetomidine on the incidence of post-thoracotomy pain syndrome in patients undergoing coronary arterybypass grafting","author":"Jabbary Moghaddam","year":"2016"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200011000-00030"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1139\/y04-028"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2009.04.004"},{"key":"ref26","first-page":"e1788","volume-title":"Safety and efficacy of dexmedetomidine as a sedative agent for performing awake intubation: a meta-analysis","author":"Zhou","year":"2016"},{"key":"ref27","first-page":"62","volume-title":"Dexmedetomidine inhibits osmotic water permeability in the rat cortical collecting duct","author":"Rouch","year":"1997"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000269488.06546.7c"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90244.2008"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.306"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199705000-00008"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-8180(99)00081-1"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/68.6.570"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.2001.01553.x"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199702000-00009"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000197777.62397.d5"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000093225.39866.75"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1017\/S0265021505000669"},{"key":"ref39","first-page":"461","volume-title":"The efficacy, side effects, and recovery characteristics of dexmedetomidine versus propofol when used for intraoperative sedation","author":"Arain","year":"2002"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1007\/BF03027725"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2005.05.009"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/78.4.400"},{"key":"ref43","first-page":"273","volume-title":"Intraoperative tachycardia and hypertension are independently associated with adverse outcome in noncardiac surgery of long duration","author":"Reich","year":"2002"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.accreview.2003.08.062"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-0770(05)80134-X"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2006.01136.x"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1097\/00008506-200401000-00005"},{"key":"ref48","first-page":"331","volume-title":"Anesthesia in the patient for awake craniotomy","author":"Frost","year":"2007"},{"key":"ref49","first-page":"1052","volume-title":"Dexmedetomidine-induced sedation in volunteers decreases regional and global cerebral blood flow","author":"Prielipp","year":"2002"},{"key":"ref50","first-page":"350","volume-title":"Dexmedetomidine decreases cerebral blood flow velocity in humans","author":"Zornow","year":"1993"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000299576.00302.4c"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-015-0315-2"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aev549"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25847"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aew024"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1097\/00008506-200307000-00015"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-200405000-00007"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aei119"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000219592.82598.AA"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2006.02171.x"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2006.02031.x"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2005.01660.x"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03520190064036"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1007\/s001340101017"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200601000-00005"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e31814b2c4d"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.22.2644"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1186\/cc8916"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.56"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000951"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.06.062"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182a16898"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30580-3"},{"key":"ref74","first-page":"1042","volume-title":"Intraoperative dexmedetomidine sedation reduces the postoperative agitated behavior in elderly patients undergoing orthopedic surgery compared to the propofol sedation","author":"Shin","year":"2017"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199212000-00014"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1989.103"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X0403200602"},{"key":"ref78","first-page":"335","volume-title":"Dexmedetomidine: a useful adjunct to consider in some high-risk situations","author":"Haselman","year":"2008"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1D615"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2009.05.015"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005278"},{"key":"ref82","first-page":"987","volume-title":"Cardiac arrest induced by dexmedetomidine","author":"Nagasaka","year":"2009"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-015-0109-0"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2017.02.176"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2017.11.004"}],"container-title":["Korean Journal of Anesthesiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ekja.org\/upload\/pdf\/kja-19259.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ekja.org\/journal\/view.php?doi=10.4097\/kja.19259","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ekja.org\/upload\/pdf\/kja-19259.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T20:47:19Z","timestamp":1573591639000},"score":1,"resource":{"primary":{"URL":"http:\/\/ekja.org\/journal\/view.php?doi=10.4097\/kja.19259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,1]]},"references-count":85,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8]]}},"URL":"https:\/\/doi.org\/10.4097\/kja.19259","relation":{},"ISSN":["2005-6419","2005-7563"],"issn-type":[{"value":"2005-6419","type":"print"},{"value":"2005-7563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,1]]},"assertion":[{"value":"2019-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-21","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-01","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}