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Since the discovery of ketamine, it has been a major topic of discussion due to controversies regarding its usage in particular sets of patients. In the past 50 years, despite its potential benefits, it is not commonly used because of concerns of \u201cemergence phenomenon,\u201d its use as a substance of abuse, and its systemic side effects. Since 2012, three World Health Organization reviews on ketamine have addressed its international control.Researchers have been studying this wonder drug for a decade worldwide. Many myths of ketamine regarding emergence phenomenon and its use in traumatic brain injury and open eye injury have been disproved in recent times. It is becoming popular in pre-hospital settings, critical care, emergency medicine, low-dose acute pain services, and adjuvant in regional anesthesia techniques. This review highlights the current consensus on the various applications of ketamine in the literature.<\/jats:p>","DOI":"10.4097\/kja.20663","type":"journal-article","created":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T04:04:02Z","timestamp":1610337842000},"page":"103-114","update-policy":"https:\/\/doi.org\/10.4097\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Comeback of ketamine: resurfacing facts and dispelling 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