{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T04:23:29Z","timestamp":1784780609270,"version":"3.55.0"},"reference-count":35,"publisher":"The Korean Society of Anesthesiologists","issue":"4","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Catholic Medical Center Research Foundation","award":["52020B000100025"],"award-info":[{"award-number":["52020B000100025"]}]}],"content-domain":{"domain":["ekja.org"],"crossmark-restriction":true},"short-container-title":["Korean J Anesthesiol"],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:p>Background: Propofol-based total intravenous anesthesia (TIVA) improves long-term outcomes after cancer surgery compared with inhalation anesthesia. However, its effect on patients undergoing non-small cell lung cancer (NSCLC) surgery remains unclear. We aimed to compare the oncological outcomes of TIVA and inhalation anesthesia after curative resection of early-stage NSCLC. Methods: We analyzed the medical records of patients diagnosed with stage I or II NSCLC who underwent curative resection at a tertiary university hospital between January 2010 and December 2017. The primary outcomes were recurrence-free survival (RFS) and overall survival (OS) according to anesthesia type.Results: We included 1,508 patients with stage I\/II NSCLC. The patients were divided into the TIVA (n = 980) and Inhalation (n = 528) groups. The two groups were well-balanced in terms of baseline clinical characteristics. The TIVA group demonstrated significantly improved RFS (7.7 years, 95% CI [7.37, 8.02]) compared with the Inhalation group (6.8 years, 95% CI [6.30, 7.22], P = 0.003). Similarly, TIVA was superior to inhalation agents with respect to OS (median OS; 8.4 years, 95% CI [8.08, 8.69] vs. 7.3 years, 95% CI [6.81, 7.71]; P &lt; 0.001). Multivariable Cox regression analysis revealed that TIVA was an independent prognostic factor related to recurrence (hazard ratio [HR]: 1.24, 95% CI [1.04, 1.47], P = 0.014) and OS (HR: 1.39, 95% CI [1.12, 1.72], P = 0.002).Conclusions: Propofol-based TIVA was associated with better RFS and OS than inhalation anesthesia in patients with stage I\/II NSCLC who underwent curative resection. <\/jats:p>","DOI":"10.4097\/kja.22584","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:09:31Z","timestamp":1672272571000},"page":"336-347","update-policy":"https:\/\/doi.org\/10.4097\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effect of total intravenous versus inhalation anesthesia on long-term oncological outcomes in patients undergoing curative resection for early-stage non-small cell lung cancer: a retrospective cohort study"],"prefix":"10.4097","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4397-9207","authenticated-orcid":true,"given":"Kwon Hui","family":"Seo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0492-3959","authenticated-orcid":true,"given":"Ji Hyung","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2799-4570","authenticated-orcid":true,"given":"Mi Hyoung","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2820-0322","authenticated-orcid":true,"given":"Wonjung","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0924-4330","authenticated-orcid":true,"given":"Sea-Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9827-5883","authenticated-orcid":true,"given":"Jin Young","family":"Chon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0411-4422","authenticated-orcid":true,"given":"Hyejin","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4299-5694","authenticated-orcid":true,"given":"Sook Hee","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9730-9845","authenticated-orcid":true,"given":"Sukil","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2573","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-017-9862-x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-16-1536"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0000000000005237"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.4103\/sja.sja_1106_20"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-019-01330-x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/aln.0000000000000936"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12867"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-14147-9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0230290"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/aln.0000000000002357"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.13301"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.04.009"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2017.11.066"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2174\/1871520621666211026092405"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.12659\/msm.898434"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"ref17","volume-title":"Cancer stat facts: lung and bronchus cancer. 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