{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:38:12Z","timestamp":1790800692717,"version":"4.1.0"},"reference-count":31,"publisher":"The Korean Society of Anesthesiologists","issue":"5","license":[{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004935","name":"Suleyman Demirel University","doi-asserted-by":"crossref","award":["TSG-2020-8134"],"award-info":[{"award-number":["TSG-2020-8134"]}],"id":[{"id":"10.13039\/501100004935","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["ekja.org"],"crossmark-restriction":true},"short-container-title":["Korean J Anesthesiol"],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:p>Background: Acute kidney injury (AKI) is a serious pathology that causes dysfunction in concentrating urine due to kidney damage, resulting in blood pressure dysregulation and increased levels of toxic metabolites. Dexpanthenol (DEX), a pantothenic acid analog, exhibits anti-inflammatory and anti-apoptotic properties in various tissues. This study investigated the protective effects of DEX against systemic inflammation-induced AKI. Methods: Thirty-two female rats were randomly assigned to the control, lipopolysaccharide (LPS), LPS+DEX, and DEX groups. LPS (5 mg\/kg, single dose on the third day, 6 h before sacrifice) and DEX (500 mg\/kg\/d for 3 d) were administered intraperitoneally.  After sacrifice, blood samples and kidney tissues were collected. Hematoxylin and eosin, caspase-3 (Cas-3), and tumor necrosis factor alpha (TNF-\u03b1) staining were performed on the kidney tissues. The total oxidant status (TOS) and total antioxidant status were measured using spectrophotometric methods. Aquaporin-2 (AQP-2), silent information regulator 1 (SIRT1), and interleukin-6 (IL-6) were detected using quantitative reverse transcription-polymerase chain reaction analysis.Results: Histopathological analysis revealed that DEX treatment ameliorated histopathological changes.  In the LPS group, an increase in the blood urea nitrogen, creatinine, urea, IL-6, Cas-3, TNF-\u03b1, and TOS levels and oxidative stress index was observed compared with the control group, whereas AQP-2 and SIRT1 levels decreased.  DEX treatment reversed these effects. Conclusions: DEX was found to effectively prevent inflammation, oxidative stress, and apoptosis in the kidneys via the SIRT1 signaling pathway. These protective properties suggest DEX\u2019s potential as a therapeutic agent for the treatment of kidney pathologies.<\/jats:p>","DOI":"10.4097\/kja.23207","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T03:46:10Z","timestamp":1685072770000},"page":"501-509","update-policy":"https:\/\/doi.org\/10.4097\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Dexpanthenol protects against lipopolysaccharide-induced acute kidney injury by restoring aquaporin-2 levels via regulation of the silent information regulator 1 signaling pathway"],"prefix":"10.4097","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8070-0159","authenticated-orcid":true,"given":"Eyy\u00fcp Sabri","family":"\u00d6zden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1545-035X","authenticated-orcid":true,"given":"Halil","family":"A\u015fc\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0560-042X","authenticated-orcid":true,"given":"Halil \u0130brahim","family":"B\u00fcy\u00fckbayram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3875-9365","authenticated-orcid":true,"given":"Mehmet Abdulkadir","family":"Sev\u00fck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3850-0137","authenticated-orcid":true,"given":"Orhan Berk","family":"\u0130meci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6061-1300","authenticated-orcid":true,"given":"Hatice K\u00fcbra","family":"Do\u011fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1835-1082","authenticated-orcid":true,"given":"\u00d6zlem","family":"\u00d6zmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2573","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-020-03656-y"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0332-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-021-00394-7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.7326\/aitc201711070"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-021-00452-0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(19)32563-2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00304.2019"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020366"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.crphys.2021.03.002"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-020-01242-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2183026"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3390\/nu14112214"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.06.009"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2021.112662"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-016-0410-7"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/cimb43030097"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.06.135"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.03.019"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-007-0452-0"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2003.11.015"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2005.08.008"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2014080741"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097\/mcc.0000000000000356"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k4891"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2015.10.011"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1097\/mot.0000000000000405"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.6683"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1080\/0886022x.2021.1871922"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.12659\/msmbr.901909"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8671713"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2017050581"}],"container-title":["Korean Journal of Anesthesiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ekja.org\/upload\/pdf\/kja-23207.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ekja.org\/journal\/view.php?doi=10.4097\/kja.23207","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ekja.org\/upload\/pdf\/kja-23207.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T19:06:21Z","timestamp":1695755181000},"score":1,"resource":{"primary":{"URL":"http:\/\/ekja.org\/journal\/view.php?doi=10.4097\/kja.23207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,1]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,10]]}},"URL":"https:\/\/doi.org\/10.4097\/kja.23207","relation":{},"ISSN":["2005-6419","2005-7563"],"issn-type":[{"value":"2005-6419","type":"print"},{"value":"2005-7563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,1]]},"assertion":[{"value":"2023-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-26","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-01","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}