{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:12:58Z","timestamp":1780344778162,"version":"3.54.1"},"reference-count":33,"publisher":"AOSIS","issue":"1","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr. J. Lab. Med."],"abstract":"<jats:p>Background:\u00a0The occurrence of high titres of alpha (anti-A) and beta (anti-B) haemolysin immunoglobulin G antibodies in blood causes haemolysis during blood transfusion from a group O donor, commonly and inappropriately known as the \u2018universal blood donor\u2019, to a group A, B or AB recipient. Surprisingly, haemolysin testing is not routinely done during blood transfusion services in Bamenda, Cameroon.Objective:\u00a0This study aimed to determine the prevalence of haemolysin among blood group \u2018O\u2019 donors at the Regional Hospital Bamenda Blood Bank, Bamenda, Cameroon.Methods:\u00a0This was a cross-sectional descriptive study carried out between June and September 2020 at the Regional Hospital Bamenda Blood Bank, Bamenda, Cameroon. Blood group O donors who were free from transfusion-transmissible infections were selected systematically and serially and their serum tested for the presence of haemolysin. Haemolysin titres were determined, and titres \u2265 8 were considered significant. The associations between haemolysin prevalence and age group, gender and Rhesus D blood group were determined using the chi-square test.Results:\u00a0The prevalence of haemolysin among the 480 study participants was 52.1% and significant haemolysin titres were detected in 18.5%. There was no association between haemolysin and gender, age group or the Rhesus D blood group.Conclusion:\u00a0The prevalence of significant titres of haemolysin among participants in this study was high. There is the need to test for haemolysin in blood group O donors to prevent the potential risk to blood group A, B, and AB recipients and to provide safer blood for transfusion.<\/jats:p>","DOI":"10.4102\/ajlm.v11i1.1432","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T15:14:59Z","timestamp":1650899699000},"source":"Crossref","is-referenced-by-count":5,"title":["Prevalence of alpha and beta haemolysin among blood group O donors in Bamenda, Cameroon"],"prefix":"10.4102","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5303-5459","authenticated-orcid":false,"given":"Victor N.","family":"Fondoh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3434-9927","authenticated-orcid":false,"given":"Nobert","family":"Ndzenjempuh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8845-7184","authenticated-orcid":false,"given":"Tamunjoh","family":"Stella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4547-2872","authenticated-orcid":false,"given":"Richard M.","family":"Fondoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9981-3786","authenticated-orcid":false,"given":"Charles N.","family":"Awasom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8136-9202","authenticated-orcid":false,"given":"Rebecca","family":"Enow-Tanjong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0450-2633","authenticated-orcid":false,"given":"Egbe P.","family":"Egbengu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1334-5628","authenticated-orcid":false,"given":"Robert","family":"Leke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4641-7832","authenticated-orcid":false,"given":"Njini F.N.","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7291-1861","authenticated-orcid":false,"given":"Denis","family":"Nsame","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2580","published-online":{"date-parts":[[2022,4,19]]},"reference":[{"key":"ref0001","author":"Boorman","year":"1977","journal-title":"Blood group serology: Theory, techniques, practical applications"},{"key":"ref0002","first-page":"115","author":"Waters","year":"1991","journal-title":"Laboratory aspects of blood transfusion. 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