{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:44:24Z","timestamp":1791193464682,"version":"4.1.0"},"reference-count":34,"publisher":"AOSIS","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr J Lab Med"],"abstract":"<jats:p>Background: Resistance of malaria parasites to existing drugs complicates treatment, but an antimalarial vaccine that could protect against this disease is not yet available. It is therefore necessary to find new effective and affordable medicines. Medicinal plants could be a potential source of antimalarial agents. Some medicinal plants from Burkina Faso were evaluated for their antiplasmodial and cytotoxic properties in vitro.Methods: Crude dichloromethane, methanol, water-methanol, aqueous and alkaloids extracts were prepared for 12 parts of 10 plants. Chloroquine-resistant malaria strain K1 was used for the\u00a0in vitro sensibility assay. The\u00a0Plasmodium lactacte dehydrogenase technique was used to determine the 50% inhibitory concentration of parasites activity (IC50). The cytotoxic effects were determined with HepG2 cells, using the tetrazolium-based colorimetric technique, and the selectivity index (SI) was calculated.Results: Sixty crude extracts were prepared. Seven extracts from\u00a0Terminalia avicenoides showed IC50 &lt;\u00a05\u00a0\u00b5g\/mL. The IC50 of dichloromethane, methanol, aqueous and alkaloids extracts ranged between 1.6 \u00b5g\/mL and 4.5\u00a0\u00b5g\/mL. Three crude extracts from\u00a0Combretum collinum and three from\u00a0Ficus capraefolia had an IC50 ranging between 0.2\u00a0\u00b5g\/mL and 2.5\u00a0\u00b5g\/mL. Crude extracts from these three plants had no cytotoxic effect, with SI\u00a0&gt;\u00a01. The other plants have mostly moderate or no antimalarial effects. Some extracts from\u00a0Cordia myxa,\u00a0Ficus capraefolia and\u00a0Opilia celtidifolia showed cytotoxicity, with an SI ranging between 0.4 and 0.9.Conclusion: Our study showed a good antiplasmodial\u00a0in vitro activity of\u00a0Terminalia avicenoides, Combretum collinum and\u00a0Ficus capraefolia. These three plants may contain antiplasmodial molecules that could be isolated by bio-guided phytochemical studies.\u00a0<\/jats:p>","DOI":"10.4102\/ajlm.v2i1.81","type":"journal-article","created":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T12:43:41Z","timestamp":1362746621000},"source":"Crossref","is-referenced-by-count":36,"title":["&lt;i&gt;In vitro&lt;\/i&gt; antiplasmodial and cytotoxic properties of some medicinal plants from western Burkina Faso"],"prefix":"10.4102","volume":"2","author":[{"given":"Souleymane","family":"Sanon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adama","family":"Gansane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamoussa 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