{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T04:04:40Z","timestamp":1692158680863},"reference-count":17,"publisher":"AOSIS","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr J Lab Med"],"abstract":"<jats:p>Introduction: Primary plasma cell leukaemia is a rare and highly aggressive disease that is\u00a0commonly diagnosed a decade earlier than multiple myeloma, at a median age of 55 years.\u00a0However, it has also been described in younger patients, as documented in this case report. It\u00a0often presents with hepatosplenomegaly and lymphadenopathy, whilst the presence of bony\u00a0lesions are less-commonly seen when compared to multiple myeloma.Case presentation: This report describes the case of a young woman who presented with\u00a0symptoms of anaemia and a history of menorrhagia. On further careful examination, she was\u00a0found to have additional signs and symptoms and was later diagnosed with primary plasma\u00a0cell leukaemia.Management and outcome: On admission, the patient received supportive care measures,\u00a0including blood products. At diagnosis, a specific chemotherapy regimen was commenced;\u00a0however, this failed to induce remission. The decision to continue with supportive care only\u00a0was made and the patient died seven months later.Discussion: This case study is presented because of its rarity, the young age of the patient at\u00a0presentation and the unusual clinical and laboratory findings. Persistent anaemia unresponsive\u00a0to standard treatment should raise the index of suspicion and further investigations directed\u00a0to exclude malignancies should be considered.\u00a0(Full article to follow)<\/jats:p>","DOI":"10.4102\/ajlm.v4i1.289","type":"journal-article","created":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T13:20:19Z","timestamp":1448544019000},"source":"Crossref","is-referenced-by-count":1,"title":["Primary plasma cell leukaemia in a 22-year-old woman: A case report"],"prefix":"10.4102","volume":"4","author":[{"given":"Robyn","family":"Marshall","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenifer","family":"Vaughan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ria","family":"David","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise","family":"Schapkaitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Carmona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracey","family":"Wiggill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2580","published-online":{"date-parts":[[2015,5,13]]},"reference":[{"key":"ref0001","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1994.tb05114.x"},{"key":"ref0002","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.133.5.813"},{"key":"ref0003","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04355.x"},{"key":"ref0004","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23339"},{"key":"ref0005","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.4"},{"key":"ref0006","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-408682"},{"issue":"3","key":"ref0007","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1182\/blood.V93.3.1032","volume":"93","author":"Garcia-Sanz","year":"1999","journal-title":"Blood."},{"key":"ref0008","doi-asserted-by":"publisher","DOI":"10.4103\/0377-4929.42533"},{"issue":"3","key":"ref0009","doi-asserted-by":"crossref","first-page":"116","DOI":"10.4103\/0019-509X.13059","volume":"40","author":"Raj","year":"2003","journal-title":"Indian J Cancer."},{"key":"ref0010","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2011.01.005"},{"key":"ref0011","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.336"},{"key":"ref0012","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20670"},{"key":"ref0013","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPENJ68FFBRIYB"},{"key":"ref0014","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2008.06.027"},{"key":"ref0015","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06237.x"},{"key":"ref0016","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.3.822"},{"issue":"7","key":"ref0017","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1182\/blood.V84.7.2283.2283","volume":"84","author":"Taniwaki","year":"1994","journal-title":"Blood."}],"container-title":["African Journal of Laboratory Medicine"],"original-title":[],"link":[{"URL":"http:\/\/ajlmonline.org\/index.php\/ajlm\/article\/viewFile\/289\/413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:05:00Z","timestamp":1692144300000},"score":1,"resource":{"primary":{"URL":"http:\/\/ajlmonline.org\/index.php\/ajlm\/article\/view\/289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,13]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,5,13]]}},"URL":"https:\/\/doi.org\/10.4102\/ajlm.v4i1.289","relation":{},"ISSN":["2225-2010","2225-2002"],"issn-type":[{"value":"2225-2010","type":"electronic"},{"value":"2225-2002","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5,13]]}}}