{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T11:19:09Z","timestamp":1787915949714,"version":"build-2784847793"},"reference-count":37,"publisher":"AOSIS","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Background:\u00a0Chronic kidney disease (CKD) is a global health concern projected to be the fifth most prevalent chronic disease by 2040, associated with high mortality and significant psychosocial burdens.\nAim:\u00a0This study aimed to explore and describe the correlation between depression and haemodialysis adequacy in CKD patients.\nSetting:\u00a0Research was conducted across five units in the Free State and Northern Cape provinces, South Africa.\nMethods:\u00a0This quantitative, cross-sectional, prospective analytic study included 78 patients selected via convenience sampling, and trustworthiness and ethical principles were adhered to throughout the study. A biostatistician analysed the raw data using the statistical analysis system (SAS). Data collected over 3 months involved objective measurements of online dialysis adequacy (Kt\/V) and pathology (creatinine, urea), alongside subjective depression assessments using the Beck Depression Inventory (BDI).\nResults:\u00a0The median BDI score was 17 (Interquartile range [IQR]: 13\u201322), r<\/jats:p>","DOI":"10.4102\/hsag.v31i0.3275","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T10:54:13Z","timestamp":1787914453000},"update-policy":"https:\/\/doi.org\/10.4102\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The correlation between depression and haemodialysis adequacy in chronic kidney disease patients in South Africa"],"prefix":"10.4102","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5955-971X","authenticated-orcid":false,"given":"Bongani V.","family":"Miya","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/033z08192","id-type":"ROR","asserted-by":"publisher"}],"name":"Central University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6428-3463","authenticated-orcid":false,"given":"Ntagi G.","family":"Marir","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/033z08192","id-type":"ROR","asserted-by":"publisher"}],"name":"Central University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4916-3152","authenticated-orcid":false,"given":"Chevon","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2580","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"Abdelmobdy, A., Mohamed, Y., Mohamed, F. & Attalla, R., 2022, \u2018Assessment of depression in haemodialysis patients and its impact on quality of life\u2019, Ain Shams Medical Journal 73, 773\u2013793. https:\/\/doi.org\/10.21608\/asmj.2022.161857.1045","DOI":"10.21608\/asmj.2022.285440"},{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Agaba, E., Lopez, A., Ma, I., Martinez, R., Tzamaloukas, R., Vanderjagt, D. et al., 2003, \u2018Chronic haemodialysis in a Nigerian teaching hospital: Practice and costs\u2019, International Journal of Artificial Organs 26, 991\u2013995. https:\/\/doi.org\/10.1177\/039139880302601104","DOI":"10.1177\/039139880302601104"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Aghsaeifard, Z., Zendehdel, A., Alizadeh, R. & Salehnasab, A., 2022, \u2018Chronic haemodialysis: Evaluation of dialysis adequacy and mortality\u2019, Annals of Medicine and Surgery 76, 1\u20135. https:\/\/doi.org\/10.1016\/j.amsu.2022.103541","DOI":"10.1016\/j.amsu.2022.103541"},{"key":"ref3","unstructured":"American Journal Experts, 2022, 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and meta-analysis\u2019, Clinical Kidney Journal 17, 1\u201311. https:\/\/doi.org\/10.1093\/ckj\/sfad274","DOI":"10.1093\/ckj\/sfae163"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Butt, M., Ong, S., Butt, F., Sajjad, A., Rasool, M., Imran, I. et al., 2022, \u2018Assessment of health-related quality of life, medication adherence, and prevalence of depression in kidney failure patients\u2019, International Journal of Environmental Research and Public Health 19, 2\u201316. https:\/\/doi.org\/10.3390\/ijerph192215266","DOI":"10.3390\/ijerph192215266"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Cedeno, S., Almudena, V., Macias, N., Sanchez, L., Abad, S., Lopez-Gomez, J. et al., 2020, \u2018Intradialytic hypotension definitions with mortality prediction capacity in a cohort of haemodialysis patients\u2019, Nefrolog\u00eda 40, 402\u2013412. 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\u2018Depression in chronic kidney disease and end-stage renal disease: Similarities and differences in diagnosis, epidemiology, and management\u2019, Kidney International Reports 2(1), 94\u2013107. https:\/\/doi.org\/10.1016\/j.ekir.2016.09.005","DOI":"10.1016\/j.ekir.2016.09.005"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Somji, S., Ruggajo, P. & Moledina, S., 2020, \u2018Adequacy of haemodialysis and its associated factors among patients undergoing chronic haemodialysis in Dar Es Salaam, Tanzania\u2019, International Journal of Nephrology 2020, 9863065. https:\/\/doi.org\/10.1155\/2020\/9863065","DOI":"10.1155\/2020\/9863065"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Thaldar, D., 2023, \u2018Does data protection law in South Africa apply to pseudonymised data?\u2019, Frontiers in Pharmacology 14, 1\u20136. https:\/\/doi.org\/10.3389\/fphar.2023.1275001","DOI":"10.3389\/fphar.2023.1238749"},{"key":"ref33","unstructured":"Thomas, L., 2023, 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