{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:31:04Z","timestamp":1785418264508,"version":"3.56.0"},"reference-count":37,"publisher":"AOSIS","issue":"4","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Background:\u00a0Sickle cell anaemia, a major genetic blood disorder, is associated with serious complications, including oral health problems, which significantly impact daily living and health-related quality of life (QoL) (HRQoL).\nAim:\u00a0To assess the impact of untreated dental caries on the QoL of children with sickle cell anaemia (SCA).\nSetting:\u00a0The study was carried out at the Obafemi Awolowo University Teaching Hospitals\u2019 Complex (OAUTHC), Ile-Ife.\nMethods:\u00a0A quasi-experimental study that included SCA children aged 8 to 16 years old with dental caries from the Paediatrics Outpatient Clinics of OAUTHC. The impact of dental caries on the oral health-related quality of life (OHRQoL) of each child was assessed pre-treatment using the Child-Oral Impact on Daily Performance (Child-OIDP) and 4 weeks post-treatment. The mean Child-OIDP scores were calculated pre- and post-treatment for the 8 different domains. A paired\u00a0t-test was used to compare the difference in the mean Child-OIDP scores pre- and post-treatment. Statistical significance was inferred at\u00a0p\u00a0&lt; 0.05.\nResults:\u00a0There were 27 children with a relatively low overall pre-treatment mean Child-OIDP score of 1.63 (standard deviation [s.d. = 3.71]), which decreased to 0.37 (s.d. = 1.21) post-treatment (p\u00a0= 0.10). The mean Child-OIDP score for the\u00a0eating\u00a0domain was significantly reduced from 0.30 (s.d. = 0.54) pre-treatment to 0.11 (s.d. = 0.42) post-treatment (p\u00a0= 0.02).\nConclusion:\u00a0The overall mean Child-OIDP score was low pre-treatment, with a decline post-treatment. There was a significant reduction in the\u00a0eating\u00a0domain post-treatment.\nContribution:\u00a0Treatment of dental caries in children with SCA will significantly improve their oral health-related QoL (OHRQoL).<\/jats:p>","DOI":"10.4102\/jphia.v16i4.1517","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T06:48:24Z","timestamp":1765781304000},"update-policy":"https:\/\/doi.org\/10.4102\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of dental caries on the quality of life of children with sickle cell anaemia in Nigeria"],"prefix":"10.4102","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0062-9367","authenticated-orcid":false,"given":"Jacob B.","family":"Afolabi","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05bkbs460","id-type":"ROR","asserted-by":"publisher"}],"name":"Obafemi Awolowo University Teaching Hospitals Complex"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4038-8778","authenticated-orcid":false,"given":"Elizabeth O.","family":"Oziegbe","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04snhqa82","id-type":"ROR","asserted-by":"publisher"}],"name":"Obafemi Awolowo University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8382-5758","authenticated-orcid":false,"given":"Samuel A.","family":"Adegoke","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04snhqa82","id-type":"ROR","asserted-by":"publisher"}],"name":"Obafemi Awolowo University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3036-5636","authenticated-orcid":false,"given":"Olufemi","family":"Adefehinti","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04snhqa82","id-type":"ROR","asserted-by":"publisher"}],"name":"Obafemi Awolowo University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9163-8215","authenticated-orcid":false,"given":"Elijah O.","family":"Oyetola","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04snhqa82","id-type":"ROR","asserted-by":"publisher"}],"name":"Obafemi Awolowo University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9008-7730","authenticated-orcid":false,"given":"Mor\u00e9nik\u00e9 O.","family":"Fol\u00e1yan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04snhqa82","id-type":"ROR","asserted-by":"publisher"}],"name":"Obafemi Awolowo University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2580","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"Adewoyin AS. 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