{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:50:36Z","timestamp":1780491036477,"version":"3.54.1"},"reference-count":0,"publisher":"Medpharm Publications","issue":"4","license":[{"start":{"date-parts":[[2000,7,10]],"date-time":"2000-07-10T00:00:00Z","timestamp":963187200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. S. Afr. Vet. Assoc."],"abstract":"<jats:p>This retrospective study describes 4 cases of canine babesiosis with histologically confirmed acute pancreatitis. In addition, 16 dogs with babesiosis are reported with serum amylase (3500 U\/l ) and\/or lipase (650 U\/l ) activity elevations of a magnitude that would support a diagnosis of probable acute pancreatitis, although extra-pancreatic sources of the enzymes could not be excluded in these cases. Median time of pancreatitis diagnosis was 2.5 days post-admission, with primarily young (median age 3 years), sexually intact dogs affected. The development of pancreatitis was unrelated to the degree of anaemia at time of admission. In addition to pancreatitis, 80 % of cases suffered from other babesial complications, namely icterus (13), acute respiratory distress syndrome (6), immune-mediated haemolytic anaemia (6), renal failure (3), haemoconcentration (2) and cerebral syndrome (2). Acute respiratory distress syndrome, renal failure and cerebral syndrome were associated with a poor prognosis, with 4 of the 5 dogs included in the overall 26 % mortality rate having at least 1 of these complications. Haemolytic anaemia with ischaemia-reperfusion injury to the pancreas is proposed as a possible primary pathophysiological mechanism in babesial pancreatitis. Hypotensive shock, immune-mediated haemolytic anaemia, haemoconcentration and possibly altered lipid metabolism in babesiosis may also be involved. The previously postulated pro-inflammatory cytokine milieu of complicated babesiosis may underlie the progression, if not the primary initiation, of pancreatic pathology. Acute pancreatitis may represent the previously reported 'gut' form of babesiosis.<\/jats:p>","DOI":"10.4102\/jsava.v71i4.721","type":"journal-article","created":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T14:24:45Z","timestamp":1345818285000},"page":"232-239","source":"Crossref","is-referenced-by-count":42,"title":["Acute pancreatitis : a newly recognised potential complication of canine babesiosis"],"prefix":"10.36303","volume":"71","author":[{"given":"A.J.","family":"M\u00f6hr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.G.","family":"Lobetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.J.","family":"Van der Lugt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22149","published-online":{"date-parts":[[2000,7,10]]},"container-title":["Journal of the South African Veterinary Association"],"original-title":[],"link":[{"URL":"https:\/\/journals.jsava.aosis.co.za\/index.php\/jsava\/article\/viewFile\/721\/695","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.jsava.aosis.co.za\/index.php\/jsava\/article\/viewFile\/721\/695","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T14:57:54Z","timestamp":1675090674000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.jsava.aosis.co.za\/index.php\/jsava\/article\/view\/721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7,10]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2000,7,10]]}},"URL":"https:\/\/doi.org\/10.4102\/jsava.v71i4.721","relation":{},"ISSN":["2224-9435","1019-9128"],"issn-type":[{"value":"2224-9435","type":"electronic"},{"value":"1019-9128","type":"print"}],"subject":[],"published":{"date-parts":[[2000,7,10]]}}}