{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:55:41Z","timestamp":1789523741877,"version":"build-2803163510"},"reference-count":16,"publisher":"Medpharm Publications","issue":"1","license":[{"start":{"date-parts":[[2012,3,28]],"date-time":"2012-03-28T00:00:00Z","timestamp":1332892800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. S. Afr. Vet. Assoc."],"abstract":"<jats:p>Sporadic outbreaks of aflatoxicosis occur in dogs when they consume contaminated dog  food. During 2011, low-cost brands of pelleted dog food were contaminated with very high  concentrations of aflatoxins. Approximately 100 dogs were presented to the Onderstepoort  Veterinary Academic Hospital. Clinically, the dogs were depressed to collapsed and icteric,  with haematemesis, melaena and haematochezia. The most common pathological findings  were icterus, gastro-enterorrhagia and hepatosis. On histopathological examination, fatty  hepatosis and bile duct proliferation were observed. A consistent, very characteristic finding  was the presence of a blue-grey granular material within the bile ducts. A total of 124 samples  of the dog food fed to the affected dogs was analysed to determine aflatoxin concentrations.  Concentrations ranged from below the limit of quantification ( 5 \u03bcg\/kg) to 4946 \u03bcg\/kg and  six samples were submitted to determine the ratio of aflatoxins in the feed. It is estimated that  well over 220 dogs died in the Gauteng Province of South Africa as a result of this aflatoxin  outbreak.<\/jats:p>","DOI":"10.4102\/jsava.v83i1.2","type":"journal-article","created":{"date-parts":[[2012,3,29]],"date-time":"2012-03-29T09:33:40Z","timestamp":1333013620000},"source":"Crossref","is-referenced-by-count":32,"title":["An outbreak of canine aflatoxicosis in Gauteng Province, South Africa"],"prefix":"10.36303","volume":"83","author":[{"given":"Luke F.","family":"Arnot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil M.","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heleen","family":"Coetzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christo J.","family":"Botha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22149","published-online":{"date-parts":[[2012,3,28]]},"reference":[{"key":"ref1","series-title":"Pathological findings in a natural outbreak of aflatoxicosis in dogs.","author":"Bastianello SS, Nesbit JW, Williams MC, Lange AL."},{"key":"ref2","series-title":"Aflatoxins in dog feed.","author":"Naicker D, Botha CJ."},{"key":"ref3","series-title":"Canine aflatoxicosis.","author":"Reyers F, Miller DB."},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.16.3.497-516.2003"},{"key":"ref5","series-title":"Veterinary diseases related to aflatoxins.","author":"Miller DM, Wilson DM."},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(94)00054-7"},{"key":"ref7","series-title":"Plant poisonings and mycotoxicoses of southern Africa.","author":"Kellerman TS, Coetzer JAW, Naude TW, Botha, CJ."},{"key":"ref8","first-page":"80","article-title":"Aflatoxins. In: Shimoda W, editor. Conference on mycotoxins in animal feeds and grains related to animal health.","author":"Edds GT.","year":"1979","journal-title":"Food and Drug Administration Report"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.07.040167.002015"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9861(02)00415-0"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2460\/javma.232.9.1329"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1021\/tx00028a004"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2002.63.1187"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-003-0536-x"},{"key":"ref15","series-title":"Strombeck\u2019s Small Animal Gastroenterology","author":"Guilford WG, Center SA, Strombeck DR, Williams DA, Meyer DJ, editors."},{"key":"ref16","series-title":"Fertilizers, Farm Feeds, Agricultural Remedies and Stock Remedies Act","author":"Government Gazette"}],"container-title":["Journal of the South African Veterinary Association"],"original-title":[],"link":[{"URL":"https:\/\/journals.jsava.aosis.co.za\/index.php\/jsava\/article\/viewFile\/2\/11","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.jsava.aosis.co.za\/index.php\/jsava\/article\/viewFile\/2\/13","content-type":"application\/epub+zip","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.jsava.aosis.co.za\/index.php\/jsava\/article\/viewFile\/2\/12","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.jsava.aosis.co.za\/index.php\/jsava\/article\/viewFile\/2\/3","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.jsava.aosis.co.za\/index.php\/jsava\/article\/viewFile\/2\/3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T14:54:04Z","timestamp":1675090444000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.jsava.aosis.co.za\/index.php\/jsava\/article\/view\/2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,28]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,4,13]]}},"URL":"https:\/\/doi.org\/10.4102\/jsava.v83i1.2","relation":{},"ISSN":["2224-9435","1019-9128"],"issn-type":[{"value":"2224-9435","type":"electronic"},{"value":"1019-9128","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3,28]]}}}