{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:19:20Z","timestamp":1760645960598},"reference-count":0,"publisher":"AOSIS","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Onderstepoort J Vet Res"],"abstract":"<jats:p>The efficacy of Leishmania donovani-derived  lipophosphoglycan (LPG) plus Mycobacterium bovis Bacille Calmette-Gu\u00e9rin  (BCG) as a vaccine candidate against visceral leishmaniosis in susceptible  BALB\/c mouse and Syrian golden hamster (Mesocricetus auratus) models was  investigated. Following a triple vaccination with a total dose of 150 \u00b5l BCG plus 60 \u00b5g or 30 \u00b5g of LPG for hamsters and BALB\/c mice respectively, there  were no noticeable side effects both locally and systemically; implying that the  molecule was safe at this dosage level. Vaccinated animals demonstrated an  activation of both the humoral as well as cell-mediated responses to LPG, which  correlated with resistance against the disease. Protection by LPG plus BCG, was  however, poor as the remaining immunized animals showed disease progression  leading to severity of the disease as illustrated by emaciation, mass loss and  heavy splenic parasitaemia in hamsters. These data nevertheless suggest that it  may be rewarding to further evaluate the potential of LPG as a vaccine candidate  in leishmaniosis using other adjuvants, which may enhance its  immunogenicity.<\/jats:p>","DOI":"10.4102\/ojvr.v70i4.290","type":"journal-article","created":{"date-parts":[[2012,8,27]],"date-time":"2012-08-27T07:22:23Z","timestamp":1346052143000},"source":"Crossref","is-referenced-by-count":11,"title":["&lt;i&gt;Leishmania donovani&lt;i\/&gt;-derived lipophosphoglycan plus BCG induces a Th1 type immune response but does not protect Syrian golden hamsters (&lt;i&gt;Mesocricetus auratus&lt;i\/&gt;) and BALB\/c mice against &lt;i&gt;Leishmania donovani&lt;i\/&gt;"],"prefix":"10.4102","volume":"70","author":[{"given":"W.K.","family":"Tonui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.S.","family":"Mpoke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.J.","family":"Turco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.A.","family":"Mbati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.M.","family":"Mkoji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2580","published-online":{"date-parts":[[2003,11,8]]},"container-title":["Onderstepoort J Vet Res"],"original-title":[],"link":[{"URL":"http:\/\/ojvr.org\/index.php\/ojvr\/article\/viewFile\/290\/269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T11:22:02Z","timestamp":1496316122000},"score":1,"resource":{"primary":{"URL":"http:\/\/ojvr.org\/index.php\/ojvr\/article\/view\/290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11,8]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2003,11,8]]}},"URL":"https:\/\/doi.org\/10.4102\/ojvr.v70i4.290","relation":{},"ISSN":["2219-0635","0030-2465"],"issn-type":[{"value":"2219-0635","type":"electronic"},{"value":"0030-2465","type":"print"}],"subject":[],"published":{"date-parts":[[2003,11,8]]}}}