{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T05:50:02Z","timestamp":1757310602187},"reference-count":0,"publisher":"AOSIS","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Onderstepoort J Vet Res"],"abstract":"<jats:p>Domestic dogs were screened for Trypanosoma  brucei infection using the haematocrit centrifugation technique as part of  routine active surveillance exercises in the Busia and Teso districts of Kenya.  The purpose was to assess the role of dogs as sentinels for the occurrence of  human sleeping sickness. Out of 200 dogs screened, five were found to be  infected at the various test sites. These five succumbed to the disease within  four weeks, and exhibited a distinct and pronounced corneal opacity before  death. Blood from two naturally infected dogs were tested for the presence of  the serum resistance associated (SRA) gene and one tested positive, confirming  it as human infective (T. brucei rhodesiense) prevalence (0.5 %). It is  considered that the occurrence of this clinical sign could be used as an early  warning prediction of future outbreaks. This type of prediction could form an  integral part of an indigenous technical knowledge set in areas lying at the  edges of the tsetse (Glossina) belts where T. brucei is the main  trypanosome species that affects dogs. The occurrence of corneal opacity in dogs  could indicate a rise in the levels of T. brucei a proportion of which  could be human infective T. b. rhodesiense circulating in the population  early enough before disease outbreak occurs. It is thought that during sleeping  sickness epidemics the domestic dog will be the first casualty rapidly  succumbing to disease long before it is noticed in man. Prompt prediction of  disease outbreaks would thus enable early interventions that would reduce the  morbidity, mortality and the general economic losses associated with sleeping  sickness to be instituted.<\/jats:p>","DOI":"10.4102\/ojvr.v70i4.296","type":"journal-article","created":{"date-parts":[[2012,8,27]],"date-time":"2012-08-27T03:22:23Z","timestamp":1346037743000},"source":"Crossref","is-referenced-by-count":13,"title":["Occurrence, clinical manifestation and the epidemiological implications of naturally occurring canine trypanosomosis in western Kenya"],"prefix":"10.4102","volume":"70","author":[{"given":"G.O.","family":"Matete","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2580","published-online":{"date-parts":[[2003,11,8]]},"container-title":["Onderstepoort J Vet Res"],"original-title":[],"link":[{"URL":"http:\/\/ojvr.org\/index.php\/ojvr\/article\/viewFile\/296\/275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T07:22:05Z","timestamp":1496301725000},"score":1,"resource":{"primary":{"URL":"http:\/\/ojvr.org\/index.php\/ojvr\/article\/view\/296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11,8]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2003,11,8]]}},"URL":"https:\/\/doi.org\/10.4102\/ojvr.v70i4.296","relation":{},"ISSN":["2219-0635","0030-2465"],"issn-type":[{"value":"2219-0635","type":"electronic"},{"value":"0030-2465","type":"print"}],"subject":[],"published":{"date-parts":[[2003,11,8]]}}}