{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T04:00:40Z","timestamp":1778040040350,"version":"3.51.4"},"reference-count":0,"publisher":"AOSIS","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Onderstepoort J Vet Res"],"abstract":"<jats:p>One third of the manufacturer's prescribed dose of  diminazene has long been used to block treat the South African unfrozen  Babesia bigemina and Babesia bovis (redwater) vaccine reactions,  with no known adverse effects. It is known that the inhibitory effect of  antibabesial drugs is more pronounced in animals inoculated with the frozen  vaccine than those with the unfrozen vaccine. Reports of vaccine failures in  some animals in which diminazene was used for block treatment of the reactions  following inoculation with frozen South African redwater vaccine led us to  reinvestigate the required waiting period before treatment and the reduced dose  necessary for successful treatment and development of immunity. Results from  febrile reactions in cattle following vaccination indicated day 7 as the optimal  day for administering block treatment. Treatment of B. bigemina vaccine  reactions in cattle on day 7 at a level of 0.35 mg\/kg (1\/10 fraction of the  normal dose) diminazene killed all the parasites while B. bovis vaccine  parasites survived treatment using diminazene at levels between 0.35 mg\/kg and  1.16 mg\/kg. However, various other factors, such as the degree of natural  resistance of different cattle breeds and individual animals, the accuracy of  diminazene content according to the manufacturer's label claim and the accuracy  of the drug dose administered, all influence the successful immunization of  animals. Consequently block treating of Babesia vaccines with diminazene  on day 7 after vaccination is not recommended.<\/jats:p>","DOI":"10.4102\/ojvr.v71i2.273","type":"journal-article","created":{"date-parts":[[2012,8,27]],"date-time":"2012-08-27T07:22:23Z","timestamp":1346052143000},"source":"Crossref","is-referenced-by-count":6,"title":["Effect of diminazene block treatment on live redwater vaccine reactions"],"prefix":"10.4102","volume":"71","author":[{"given":"M.P.","family":"Combrink","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.C.","family":"Troskie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2580","published-online":{"date-parts":[[2004,11,8]]},"container-title":["Onderstepoort J Vet Res"],"original-title":[],"link":[{"URL":"http:\/\/ojvr.org\/index.php\/ojvr\/article\/viewFile\/273\/252","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T11:21:55Z","timestamp":1496316115000},"score":1,"resource":{"primary":{"URL":"http:\/\/ojvr.org\/index.php\/ojvr\/article\/view\/273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,8]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2004,11,8]]}},"URL":"https:\/\/doi.org\/10.4102\/ojvr.v71i2.273","relation":{},"ISSN":["2219-0635","0030-2465"],"issn-type":[{"value":"2219-0635","type":"electronic"},{"value":"0030-2465","type":"print"}],"subject":[],"published":{"date-parts":[[2004,11,8]]}}}