{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T19:23:45Z","timestamp":1778181825688,"version":"3.51.4"},"reference-count":0,"publisher":"AOSIS","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Onderstepoort J Vet Res"],"abstract":"<jats:p>The effects of dexamethasone and promethazine on the  amelioration of pulmonary oedema in East Coast fever were investigated. The  clinical effects of these drugs were further investigated when used in  conjunction with the antitheilerial drug, buparvaquone. In the first experiment,  15 crossbred (Friesian x Zebu) steers were divided into four groups. With the  exception of the animals in group IV, that served as a control group all the  others were infected with Theileria parva sporozoites. On the second day  of the febrile reaction, the steers in groups I and II were treated with  dexamethasone (0.1 mg\/kg) and promethazine (1 mg\/kg), respectively. Group III  steers served as the infected untreated controls. On the fifth day of the  febrile reaction the animals in groups I, II and III were infused intravenously  with tattoo ink suspension and 1 h later sacrificed for post-mortem examination  and tissue sampling. The clinical picture indicated that both drugs  significantly mitigated dyspnoea and the post mortem examination revealed a  significant reduction in morphological changes. Tattoo ink particle count  reflected a significant (P &lt; 0.01) reduction in vascular leakage in  the treated animals, with promethazine being significantly (P &lt; 0.05)  more effective than dexamethasone in this respect. In the second experiment, 18  steers were infected with T. parva sporozoites, and then were randomly  allotted into three groups each of which contained six animals. After the onset  of ECF clinical signs, the animals in the first two groups were treated with  buparvaquone in combination with either dexamethasone (group I) or promethazine  (group II), and the third group was treated with buparvaquone alone. The results  indicated that all the animals in groups I, II and III recovered well and no  significant differences were observed in clinical disposition between the  groups. Two months later, serum samples were collected from the refractory  animals and demonstrated the presence of antibodies against T. parva.  When the animals were subsequently artificially challenged with T. parva,  none of them succumbed to clinical disease. The same T. parva stabilate  stock was used in both experiments and it proved to be infective in a separate  batch of steers.<\/jats:p>","DOI":"10.4102\/ojvr.v71i2.274","type":"journal-article","created":{"date-parts":[[2012,8,27]],"date-time":"2012-08-27T07:22:23Z","timestamp":1346052143000},"source":"Crossref","is-referenced-by-count":5,"title":["The effect of dexamethasone and promethazine in combination with buparvaquone in the management of East Coast fever"],"prefix":"10.4102","volume":"71","author":[{"given":"M.","family":"Gwamaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Matovelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.M.A.","family":"Mtambo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.K.","family":"Mbassa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.M.","family":"Maselle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Boniphace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2580","published-online":{"date-parts":[[2004,11,8]]},"container-title":["Onderstepoort J Vet Res"],"original-title":[],"link":[{"URL":"http:\/\/ojvr.org\/index.php\/ojvr\/article\/viewFile\/274\/253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T11:21:55Z","timestamp":1496316115000},"score":1,"resource":{"primary":{"URL":"http:\/\/ojvr.org\/index.php\/ojvr\/article\/view\/274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,8]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2004,11,8]]}},"URL":"https:\/\/doi.org\/10.4102\/ojvr.v71i2.274","relation":{},"ISSN":["2219-0635","0030-2465"],"issn-type":[{"value":"2219-0635","type":"electronic"},{"value":"0030-2465","type":"print"}],"subject":[],"published":{"date-parts":[[2004,11,8]]}}}