{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:30:08Z","timestamp":1790883008018,"version":"4.1.0"},"reference-count":0,"publisher":"AOSIS","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Onderstepoort J Vet Res"],"abstract":"<jats:p>Haemonchus contortus and Trichostrongylus  colubriformis are among the most important parasitic nematodes of small  ruminants. Caenorhabditis elegans, a free-living nematode, is used as a  model for evaluating anthelmintic activity of a variety of test substances.  Extracts of several medicinal plants are useful in vitro and in  vivo against nematode development. Extracts of Curtisia dentata, a  South African medicinal plant, and compounds isolated from leaves of this plant  were investigated for anthelmintic activity against T. colubriformis, H.  contortus and C. elegans. The acetone and dichloromethane extracts  were active against all nematodes at concentrations as low as 160 \u03bcg\/m\u2113.  Betulinic acid and lupeol were active against the parasitic nematodes only at  the high concentrations of 1 000 and 200 \u03bcg\/m\u2113, respectively. All compounds were  effective against C. elegans with active concentrations as low as 8  \u03bcg\/m\u2113. Betulinic acid was less active than lupeol and ursolic acid against C.  elegans. The acetone and dichloromethane extracts were also active against  C. elegans with a concentration of 0.31 mg\/m\u2113 resulting in almost 80 %  inhibition of larval motility. The use of free-living nematodes may provide  information on the activity of potential anthelmintics against parasitic  nematodes. Extracts of various medicinal plant species may provide solutions to  ill-health of small ruminants caused by parasitic nematodes in poor communities  of southern Africa.<\/jats:p>","DOI":"10.4102\/ojvr.v76i2.49","type":"journal-article","created":{"date-parts":[[2012,8,27]],"date-time":"2012-08-27T03:21:52Z","timestamp":1346037712000},"source":"Crossref","is-referenced-by-count":23,"title":["&lt;i&gt;Curtisia dentata&lt;\/i&gt; (Cornaceae) leaf extracts and isolated compounds inhibit motility of parasitic and free-living nematodes"],"prefix":"10.4102","volume":"76","author":[{"given":"L.J.","family":"Shai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.S.","family":"Bizimenyera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Bagla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.J.","family":"McGaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.N.","family":"Eloff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2580","published-online":{"date-parts":[[2009,9,9]]},"container-title":["Onderstepoort J Vet Res"],"original-title":[],"link":[{"URL":"http:\/\/ojvr.org\/index.php\/ojvr\/article\/viewFile\/49\/43","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T07:20:17Z","timestamp":1496301617000},"score":1,"resource":{"primary":{"URL":"http:\/\/ojvr.org\/index.php\/ojvr\/article\/view\/49"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,9]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,9,9]]}},"URL":"https:\/\/doi.org\/10.4102\/ojvr.v76i2.49","relation":{},"ISSN":["2219-0635","0030-2465"],"issn-type":[{"value":"2219-0635","type":"electronic"},{"value":"0030-2465","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9,9]]}}}