{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:25:18Z","timestamp":1791397518023,"version":"4.3.3"},"reference-count":32,"publisher":"AOSIS","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Onderstepoort J Vet Res"],"abstract":"<jats:p>Several lyssavirus species occur in Africa (Rabies virus, Lagos bat virus, Mokola virus,  Duvenhage virus, Shimoni bat virus and Ikoma lyssavirus), displaying a high sequence  diversity between isolates belonging to the same species. There is limited information about  comparative pathogenesis of these African lyssaviruses and this precludes authoritative  opinion on the potential public and veterinary health impact. In this study, an analysis of  representative African lyssaviruses attempted to correlate viral genomic sequence similarities  and differences with the corresponding pathogenic profiles observed in mice. The study  demonstrated that the virus isolates evaluated could be lethal to mice when introduced  intramuscularly and that different isolates of the same lyssavirus species differ in their  virulence. Using real-time polymerase chain reaction (PCR), viral RNA was detected in brain  tissue, but no viral RNA was detected in the salivary glands or blood of mice that succumbed  to infection. Comparison of known pathogenic domains indicated that pathogenicity is likely  to be dependent on multiple domains. Cumulatively, our results re-emphasised the realisation  that the pathogenicity of a lyssavirus species cannot be deduced based on studies of only a  single isolate of the species or a single pathogenic domain.<\/jats:p>","DOI":"10.4102\/ojvr.v80i1.511","type":"journal-article","created":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T14:36:12Z","timestamp":1362753372000},"source":"Crossref","is-referenced-by-count":24,"title":["Comparison of pathogenic domains of rabies and African rabies-related lyssaviruses and pathogenicity observed in mice"],"prefix":"10.4102","volume":"80","author":[{"given":"Joe","family":"Kgaladi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis H.","family":"Nel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanda","family":"Markotter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2580","published-online":{"date-parts":[[2013,3,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.7.3268-3276.2001"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(70)90444-7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01256-10"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3201\/eid1312.070836"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.1.70"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2217\/17460794.3.5.481"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.22.14141-14148.2005"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02651-07"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-005-0785-0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.83096-0"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/BF01250419"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00016-08"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2010.01.018"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M201374200"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1126\/science.6494916"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2004.11.008"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2005.09.004"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3201\/eid1212.060514"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3201\/eid1203.051306"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2008.02.001"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268808001945"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3201\/eid1804.111553"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2010.09.016"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2008.05.011"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2004.12.003"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01964-06"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2009.00609.x"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2005.08.004"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701397104"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.4102\/sajs.v107i11\/12.177"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15792-9"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00889-08"}],"container-title":["Onderstepoort J Vet Res"],"original-title":[],"link":[{"URL":"http:\/\/ojvr.org\/index.php\/ojvr\/article\/viewFile\/511\/804","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T11:18:50Z","timestamp":1496315930000},"score":1,"resource":{"primary":{"URL":"http:\/\/ojvr.org\/index.php\/ojvr\/article\/view\/511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,4]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,3,4]]}},"URL":"https:\/\/doi.org\/10.4102\/ojvr.v80i1.511","relation":{},"ISSN":["2219-0635","0030-2465"],"issn-type":[{"value":"2219-0635","type":"electronic"},{"value":"0030-2465","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3,4]]}}}