{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:28:49Z","timestamp":1790998129479,"version":"4.1.0"},"reference-count":34,"publisher":"AOSIS","issue":"1","license":[{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Onderstepoort j. vet. res."],"abstract":"<jats:p>Aflatoxins are potent hepatotoxic and carcinogenic secondary metabolites produced by toxigenic fungi. The present study investigated the protective effect of methanolic leaf extracts of\u00a0Monanthotaxis caffra\u00a0(MLEMC) against aflatoxin B1-induced toxicity in male Sprague-Dawley rats. The rats were randomly divided into 6 groups of 8 animals each. Five groups were administered orally for seven days with three different concentrations of MLEMC (100 mg\/kg, 200 mg\/kg and 300 mg\/kg), curcumin (10 mg\/kg) or vehicle (25% propylene glycol). The following day, these groups were administered 1 mg\/kg b.w. of aflatoxin B1\u00a0(AFB1). The experiment was terminated three days after administration of AFB1. Group 6 represented untreated healthy control. Serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, creatinine and liver histopathology were evaluated. Methanolic leaf extracts of\u00a0M. caffra\u00a0decreased the levels of aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase and creatinine in the sera of rats as compared with the AFB1\u00a0intoxicated group. Co-administration of MLEMC improved the histological characteristics of the hepatocytes in contrast to the AFB1\u00a0treated group, which had mild to severe hepatocellular injuries including bile duct proliferation, bile duct hyperplasia, lymphoplasmacytic infiltrate and fibrosis. Extracts of\u00a0M. caffra\u00a0were beneficial in mitigating the hepatotoxic effects of AFB1\u00a0in rats by reducing the levels of liver enzymes and preventing hepatic injury.<\/jats:p>","DOI":"10.4102\/ojvr.v89i1.1968","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T11:00:25Z","timestamp":1647860425000},"source":"Crossref","is-referenced-by-count":12,"title":["Protective effects of methanolic leaf extracts of Monanthotaxis caffra against aflatoxin B1-induced hepatotoxicity in rats"],"prefix":"10.4102","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4154-9302","authenticated-orcid":false,"given":"Rhulani","family":"Makhuvele","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0661-9579","authenticated-orcid":false,"given":"Kenn","family":"Foubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3946-7313","authenticated-orcid":false,"given":"Nina","family":"Hermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8288-4254","authenticated-orcid":false,"given":"Luc","family":"Pieters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4622-4723","authenticated-orcid":false,"given":"Luc","family":"Verschaeve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2207-306X","authenticated-orcid":false,"given":"Esam","family":"Elgorashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2580","published-online":{"date-parts":[[2022,3,23]]},"reference":[{"key":"ref0001","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63603-4.00004-8"},{"key":"ref0002","doi-asserted-by":"publisher","DOI":"10.1006\/rtph.1998.1201"},{"key":"ref0003","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2005.11.018"},{"issue":"10","key":"ref0004","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1016\/j.fct.2010.07.001","volume":"48","author":"Choi","year":"2010","journal-title":"Food & Chemical Toxicology"},{"key":"ref0005","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.2.331"},{"key":"ref0006","doi-asserted-by":"publisher","DOI":"10.1100\/2012\/462925"},{"key":"ref0007","doi-asserted-by":"publisher","DOI":"10.2174\/138920112798868791"},{"key":"ref0008","doi-asserted-by":"publisher","DOI":"10.1007\/BF02931073"},{"key":"ref0009","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-010-0511-2"},{"issue":"6","key":"ref0010","first-page":"6019","volume":"8","author":"El-Mahalaway","year":"2015","journal-title":"International Journal of Clinical and Experimental Pathology"},{"issue":"6","key":"ref0011","first-page":"1125","volume":"87","author":"Gowda","year":"2008","journal-title":"Journal of Nutrition and Metabolism"},{"issue":"7","key":"ref0012","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/jphp.12918","volume":"70","author":"Makhuvele","year":"2018b","journal-title":"Journal of Pharmacy & Pharmacology"},{"key":"ref0013","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2017.10.016"},{"key":"ref0014","doi-asserted-by":"publisher","DOI":"10.1007\/s10616-013-9579-x"},{"issue":"3","key":"ref0015","first-page":"339","volume":"65","author":"Mathuria","year":"2008","journal-title":"Acta Poloniae Pharmaceutica"},{"key":"ref0016","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-1978(99)00099-X"},{"key":"ref0017","author":"National Research Council","year":"2008","journal-title":"Lost crops of Africa, Vol. III, Fruits"},{"key":"ref0018","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.12.010"},{"issue":"2","key":"ref0019","first-page":"211","volume":"5","author":"Okhale","year":"2016","journal-title":"Journal of Pharmacognosy and Phytochemistry"},{"issue":"3","key":"ref0020","first-page":"221","volume":"38","author":"Parmena","year":"2012","journal-title":"Tanzania Journal of Science"},{"key":"ref0021","doi-asserted-by":"publisher","DOI":"10.4265\/bio.20.171"},{"key":"ref0022","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02908"},{"key":"ref0023","doi-asserted-by":"publisher","DOI":"10.1258\/la.2012.012130"},{"key":"ref0024","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.fct.2018.11.047","volume":"124","author":"Rushing","year":"2019","journal-title":"Food & Chemical Toxicology"},{"key":"ref0025","first-page":"97","volume":"5","author":"Sathya","year":"2012","journal-title":"Asian Journal of Pharmaceutical and clinical Research"},{"key":"ref0026","first-page":"1","author":"Shan","year":"2019","journal-title":"Aflatoxin B1 occurrence, detection and toxicological effects"},{"key":"ref0027","doi-asserted-by":"publisher","DOI":"10.1016\/0957-4166(96)00004-3"},{"key":"ref0028","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(97)04710-1"},{"key":"ref0029","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2011.10.014"},{"key":"ref0030","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2006.12.001"},{"issue":"4","key":"ref0031","first-page":"314","volume":"17","author":"Valchev","year":"2014","journal-title":"Bulgarian Journal of Veterinary Medicine"},{"key":"ref0032","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-016-1217-7"},{"key":"ref0033","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2018.07.007"},{"key":"ref0034","doi-asserted-by":"crossref","first-page":"110768","DOI":"10.1016\/j.fct.2019.110768","volume":"135","author":"Zarev","year":"2020","journal-title":"Food & Chemical Toxicology"}],"container-title":["Onderstepoort Journal of Veterinary Research"],"original-title":[],"link":[{"URL":"https:\/\/ojvr.org\/index.php\/ojvr\/article\/viewFile\/1968\/2351","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ojvr.org\/index.php\/ojvr\/article\/viewFile\/1968\/2352","content-type":"application\/epub+zip","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ojvr.org\/index.php\/ojvr\/article\/viewFile\/1968\/2353","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ojvr.org\/index.php\/ojvr\/article\/viewFile\/1968\/2354","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ojvr.org\/index.php\/ojvr\/article\/viewFile\/1968\/2354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T09:45:53Z","timestamp":1650620753000},"score":1,"resource":{"primary":{"URL":"https:\/\/ojvr.org\/index.php\/ojvr\/article\/view\/1968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,23]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1,10]]}},"URL":"https:\/\/doi.org\/10.4102\/ojvr.v89i1.1968","relation":{},"ISSN":["2219-0635","0030-2465"],"issn-type":[{"value":"2219-0635","type":"electronic"},{"value":"0030-2465","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3,23]]}}}