{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:28:16Z","timestamp":1790965696926,"version":"4.1.0"},"reference-count":50,"publisher":"AOSIS","issue":"1","license":[{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Onderstepoort j. vet. res."],"abstract":"<jats:p>Rabies is a zoonotic disease that remains endemic in large parts of southern Africa because of its persistence in wildlife and domestic dog vectors. The black-backed jackals (Canis mesomelas) is primarily the wildlife vector responsible for rabies outbreaks in northern parts of South Africa. Two trials were carried out to investigate antibody responses to the oral rabies vaccine Raboral V-RG\u00ae in black-backed jackals under captive and free-ranging conditions. In captive jackals 10\/12 (83%; 95% confidence interval [CI]: 52% \u2013 98%), seroconverted after single oral vaccination. Nine captive jackals had protective antibody titres ( 0.5 IU\/mL) at 4 weeks (median: 2.1 IU\/mL; inter quartile range [IQR]: 0.6\u20135.7) and 10 jackals had at 12 weeks (median: 3.5 IU\/mL; IQR: 1.5\u20138.3) and three maintained antibody titres for up to 48 weeks (median: 3.4 IU\/mL; IQR: 2.0\u20136.3). Four sites were baited with Raboral V-RG\u00ae vaccine for wild jackals, using fishmeal polymer and chicken heads. Baits were distributed by hand or from vehicle at three sites in north-eastern South Africa, with an average baiting density of 4.4 baits\/km2\u00a0and at one site in central South Africa, at 0.12 baits\/km2. This resulted in protective antibody titres in 3\/11 jackals (27%; 95% Cl: 6\u201361) trapped between 3 and 12 months after baiting in north-eastern South Africa, compared with 4\/7 jackals (57%; 95% Cl: 18\u201390) trapped after 3\u201318 months in central South Africa. This study shows the potential utility of oral rabies vaccination for the control of wildlife-associated rabies in north-eastern and central South Africa, but extensive studies with wider distribution of bait are needed to assess its potential impact on rabies control in wild jackals.<\/jats:p>","DOI":"10.4102\/ojvr.v89i1.1975","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T12:58:18Z","timestamp":1644497898000},"source":"Crossref","is-referenced-by-count":6,"title":["Antibody response to Raboral VR-G\u00ae oral rabies vaccine in captive and free-ranging black-backed jackals (Canis mesomelas)"],"prefix":"10.4102","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5816-9245","authenticated-orcid":false,"given":"Katja 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