{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:42:04Z","timestamp":1785422524642,"version":"3.56.0"},"reference-count":55,"publisher":"AOSIS","issue":"1","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>The main objective of this study is to evaluate the humoral response of 33 captive non-human primates from the Friguia zoo Park (Sousse district, Tunisia) following vaccination with an adjuvanted and inactivated rabies virus vaccine. The animals were sampled at day one, then at day 30, day 180 and day 365 post-vaccination. Antibody titration was performed using the FAVN (fluorescent antibody virus neutralisation) method in the national reference laboratory for rabies in Tunisia at the Pasteur Institute of Tunis. One-month post-vaccination, 100% of animals seroconverted, and 76.5% maintained a high titre up to 1 year. However, a decrease in titres was observed at day 180 and day 365, mainly in baboons and apes, respectively, whereas lemurs maintained a high titre up to 1-year post-vaccination.\nContribution:\u00a0In light of these results, we can recommend that the vaccination protocol for the primates at Friguia zoo Park be based on an initial vaccination with the adjuvanted and inactivated rabies virus vaccine, followed by an annual booster for lemurs and a semi-annual booster for baboons and apes.<\/jats:p>","DOI":"10.4102\/ojvr.v93i1.2238","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T11:57:42Z","timestamp":1770983862000},"update-policy":"https:\/\/doi.org\/10.4102\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Kinetics of rabies-neutralising antibodies in non-human primates after the injection of adjuvanted and inactivated rabies vaccine"],"prefix":"10.4102","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0805-3342","authenticated-orcid":false,"given":"Yacine","family":"Souissi","sequence":"first","affiliation":[{"name":"Laboratory of Infectious Animal Diseases, Zoonoses and Sanitary Regulation, National School of Veterinary Medicine of Sidi Thabet, Manouba University, Ariana, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7494-0463","authenticated-orcid":false,"given":"Mariem","family":"Handous","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/029cgt552","id-type":"ROR","asserted-by":"publisher"}],"name":"Tunis El Manar University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7674-2006","authenticated-orcid":false,"given":"Mohamed","family":"Bayoudh","sequence":"additional","affiliation":[{"name":"Friguia Zoo Parc, Ennfidha, Sousse, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1320-8916","authenticated-orcid":false,"given":"Sarra","family":"Torjemane","sequence":"additional","affiliation":[{"name":"Laboratory of Infectious Animal Diseases, Zoonoses and Sanitary Regulation, National School of Veterinary Medicine of Sidi Thabet, Manouba University, Ariana, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1426-4723","authenticated-orcid":false,"given":"M\u00e9diha","family":"Khamassi Khbou","sequence":"additional","affiliation":[{"name":"Laboratory of Infectious Animal Diseases, Zoonoses and Sanitary Regulation, National School of Veterinary Medicine of Sidi Thabet, Manouba University, Ariana, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2580","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"Albas, A., Picolo, M., Soares, C., Bachega, H.V. & Tarumoto, M., 2013, \u2018Humoral immune response in dogs and cats vaccinated against rabies in southeastern Brazil\u2019, Journal of Venomous Animals and Toxins Including Tropical Diseases 19(1), 17. https:\/\/doi.org\/10.1186\/1678-9199-19-17","DOI":"10.1186\/1678-9199-19-17"},{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Almeida, M.F., Aguiar, E.A.C., Martorelli, L.A.F., Presotto, D., Brand\u00e3o, M.M. & Pereira, O.A.C., 1997, \u2018Resposta imune humoral de c\u00e3es \u00e0 vacina inativada, de c\u00e9rebro de camundongos lactentes, utilizada nas campanhas anti-r\u00e1bicas no Brasil\u2019, Revista de Sa\u00fade P\u00fablica 31(5), 502\u2013507. https:\/\/doi.org\/10.1590\/S0034-89101997000600009","DOI":"10.1590\/S0034-89101997000600009"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Baer, G.M. 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