{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:13:46Z","timestamp":1785417226293,"version":"3.56.0"},"reference-count":35,"publisher":"AOSIS","issue":"1","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Background:\u00a0Infection with the human papillomavirus (HPV) is a necessary cause of cervical cancer and is one of the most prevalent sexually transmitted infections worldwide. Primary prevention strategies target reducing HPV acquisition through vaccination, limiting exposure (e.g. delayed sexual debut, barrier contraception) and health education focusing on sexual behaviour and tobacco use.\n\nMethods:\u00a0The ImmunoVACCS study, conducted from 2019 to 2022 in two provinces in South Africa, examined sociodemographic characteristics, sexual practices, and knowledge of cervical cancer and the HPV vaccine among young female vaccine recipients. It encompassed participants from the previously conducted vaccine implementation trials, VACCS 1 and VACCS 2 (2011\u20132014). Recruitment involved telephonic contact with eligible potential participants. Data were collected through self-administered questionnaires.\n\nResults:\u00a0One hundred and eleven participants took part in the current study (median age: 20 years; age range: 16\u201322 years). Most sexually active participants had their first engagement in secondary school (96.2%), and 77.2% used contraception during their last sexual activity. Knowledge gaps were evident, with only 13.5% recognising cervical cancer\u2019s cervix origin and 3.6% attributing it to a virus. Despite this, 70.3% had heard of a vaccine for cervical cancer. Less than half knew about the importance of regular Pap smears (49.5%), vaccine protection (44.1%) or condom use (20.7%) against HPV and cervical cancer.\n\nConclusion:\u00a0The current study demonstrates that young women still lack complete information on cervical cancer and its risk factors even after receiving health education linked with vaccination.\n\nContribution:\u00a0This study underscores the necessity of ongoing education about HPV, its risks and preventive measures among young women to combat cervical cancer.<\/jats:p>","DOI":"10.4102\/safp.v66i1.5913","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T18:06:42Z","timestamp":1713982002000},"update-policy":"https:\/\/doi.org\/10.4102\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Sociodemographics, behaviour and knowledge of first South African HPV-vaccine recipients"],"prefix":"10.4102","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1473-5054","authenticated-orcid":false,"given":"Robyn A.","family":"Adams","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05bk57929","id-type":"ROR","asserted-by":"publisher"}],"name":"Stellenbosch University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2873-460X","authenticated-orcid":false,"given":"Cathy","family":"Visser","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00g0p6g84","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Pretoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0769-8408","authenticated-orcid":false,"given":"Greta","family":"Dreyer","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00g0p6g84","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Pretoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7502-2867","authenticated-orcid":false,"given":"Leon","family":"Snyman","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00g0p6g84","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Pretoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1486-7030","authenticated-orcid":false,"given":"Frederick H.","family":"van der Merwe","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05bk57929","id-type":"ROR","asserted-by":"publisher"}],"name":"Stellenbosch University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6046-1453","authenticated-orcid":false,"given":"Matthys H.","family":"Botha","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05bk57929","id-type":"ROR","asserted-by":"publisher"}],"name":"Stellenbosch University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2580","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"Chesson HW, Dunne EF, Hariri S, Markowitz LE. The estimated lifetime probability of acquiring human papillomavirus in the United States. Sex Transm Dis. 2014 Nov 12;41(11):660\u2013664. https:\/\/doi.org\/10.1097\/OLQ.0000000000000193","DOI":"10.1097\/OLQ.0000000000000193"},{"key":"ref1","doi-asserted-by":"crossref","unstructured":"McGraw SL. Update on prevention and screening of cervical cancer. World J Clin Oncol. 2014;5(4):744\u2013752. https:\/\/doi.org\/10.5306\/wjco.v5.i4.744","DOI":"10.5306\/wjco.v5.i4.744"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Wright TC, Van Damme P, Schmitt HJ, Meheus A. Chapter 14: HPV vaccine introduction in industrialized countries. Vaccine. 2006 Aug 31;24(Suppl 3):S3\/122\u2013131. https:\/\/doi.org\/10.1016\/j.vaccine.2006.05.118","DOI":"10.1016\/j.vaccine.2006.05.118"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Hildesheim A, Herrero R, Wacholder S, et al. Effect of human papillomavirus 16\/18 L1 virus like particle vaccine among young women with preexisting infection a randomized trial. JAMA. 2007 Aug 15;298(7):743\u2013753. https:\/\/doi.org\/10.1001\/jama.298.7.743","DOI":"10.1001\/jama.298.7.743"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Villa LL. Introduction of HPV prophylactic vaccines: A new challenge for public health in the 21st century. Rev Bras Epidemiol. 2008 Sep;11(3):516. https:\/\/doi.org\/10.1590\/S1415-790X2008000300019","DOI":"10.1590\/S1415-790X2008000300019"},{"key":"ref5","unstructured":"South African Government: Basic Education on roll-out of human papillomavirus (HPV) vaccine programme [homepage on the Internet]. 2014 [cited 2024 Feb 25]. Available from: https:\/\/www.gov.za\/news\/basic-education-roll-out-human-papillomavirus-hpv-vaccine-programme-11-feb-2014"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Delany-Moretlwe S, Kelley KF, James S, et al. Human papillomavirus vaccine introduction in South Africa: Implementation lessons from an evaluation of the national school-based vaccination campaign. Glob Health Sci Pract. 2018 Oct 3;6(3):425\u2013438. https:\/\/doi.org\/10.9745\/GHSP-D-18-00090","DOI":"10.9745\/GHSP-D-18-00090"},{"key":"ref7","unstructured":"Villa LL, Costa RL, Petta CA, et al. Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: A randomised double-blind placebo-controlled multicentre phase II efficacy trial. Lancet Oncol. 2005 May;6(5):271\u2013278."},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Garland SM, Hernandez-Avila M, Wheeler CM, et al. Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases. N Engl J Med. 2007 May 10;356(19):1928\u20131943. https:\/\/doi.org\/10.1056\/NEJMoa061760","DOI":"10.1056\/NEJMoa061760"},{"key":"ref9","unstructured":"World Health Organization. Immunization data portal [homepage on the Internet]. [cited 2024 Mar 02]. Available from: https:\/\/immunizationdata.who.int\/"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Kutz JM, Rausche P, Gheit T, Puradiredja DI, Fusco D. Barriers and facilitators of HPV vaccination in sub-saharan Africa: A systematic review. BMC Public Health. 2023 May 26;23(1):974. https:\/\/doi.org\/10.1186\/s12889-023-15842-1","DOI":"10.1186\/s12889-023-15842-1"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Wigle J, Coast E, Watson-Jones D. Human papillomavirus (HPV) vaccine implementation in low and middle-income countries (LMICs): Health system experiences and prospects. Vaccine. 2013 Aug;31(37):3811\u20133817. https:\/\/doi.org\/10.1016\/j.vaccine.2013.06.016","DOI":"10.1016\/j.vaccine.2013.06.016"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Botha MH, Van Der Merwe FH, Snyman LC, Dreyer G. The vaccine and cervical cancer screen (VACCS) project: Acceptance of human papillomavirus vaccination in a school-based programme in two provinces of South Africa. S Afr Med J. 2015;105(1):40\u201343. https:\/\/doi.org\/10.7196\/SAMJ.8419","DOI":"10.7196\/SAMJ.8419"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Dreyer G, Botha MH, Snyman LC, et al. Combining cervical cancer screening for mothers with schoolgirl vaccination during human papillomavirus (HPV) vaccine implementation in South Africa: Results from the VACCS1 and VACCS2 trials. Int J Gynecol Cancer. 2022; 32(5):592\u2013598. https:\/\/doi.org\/10.1136\/ijgc-2021-003079","DOI":"10.1136\/ijgc-2021-003079"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Dreyer G, Van Der Merwe FH, Botha MH, et al. School-based human papillomavirus vaccination: An opportunity to increase knowledge about cervical cancer and improve uptake of screening. S Afr Med J. 2015 Nov 1;105(11):912\u2013916. https:\/\/doi.org\/10.7196\/SAMJ.2015.v105i11.9814","DOI":"10.7196\/SAMJ.2015.v105i11.9814"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Snyman LC, Dreyer G, Visser C, Botha MH, Van Der Merwe FH. The vaccine and cervical cancer screen project 2 (VACCS 2): Linking cervical cancer screening to a two-dose HPV vaccination schedule in the South-West district of Tshwane, Gauteng, South Africa. S Afr Med J. 2015;105(3):191\u2013194. https:\/\/doi.org\/10.7196\/SAMJ.8888","DOI":"10.7196\/SAMJ.8888"},{"key":"ref16","unstructured":"Centres for Disease Control and Prevention. State and local Youth Risk Behavior Survey (YRBS) [homepage on the Internet]. 2017 [cited 2018 Jan 06]. Available from: https:\/\/www.cdc.gov\/healthyyouth\/data\/yrbs\/pdf\/2017\/2017_yrbs_standard_hs_questionnaire.pdf"},{"key":"ref17","unstructured":"Payne CM. Sexual behavior questionnaire: Association between school-based sex education and contraceptive use among sexually active emerging adults [homepage on the Internet]. University of Florida Digital Collections (UFDC); 2009 [cited 2018 Jan 06]. Available from: https:\/\/ufdc.ufl.edu\/UFE0024723\/00001\/pdf\/1"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Makiwane M, Kwizera S. Youth and well-being: A South African case study. Soc Indic Res. 2009;91(2):223\u2013242. https:\/\/doi.org\/10.1007\/s11205-008-9279-7","DOI":"10.1007\/s11205-008-9279-7"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Baussano I, Lazzarato F, Ronco G, Dillner J, Franceschi S. Benefits of catch-up in vaccination against human papillomavirus in medium- and low-income countries. Int J Cancer. 2013 Oct 15;133(8):1876\u20131881. https:\/\/doi.org\/10.1002\/ijc.28197","DOI":"10.1002\/ijc.28197"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Silverberg MJ, Leyden WA, Lam JO, et al. Effectiveness of catch-up human papillomavirus vaccination on incident cervical neoplasia in a US health-care setting: A population-based case-control study. Lancet Child Adolesc Health. 2018 Oct;2(10):707\u2013714. https:\/\/doi.org\/10.1016\/S2352-4642(18)30220-7","DOI":"10.1016\/S2352-4642(18)30220-7"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Martellucci CA, Morettini M, Brotherton JML, et al. Impact of a human papillomavirus vaccination program within organized cervical cancer screening: Cohort study. Cancer Epidemiol Biomarkers Prev. 2022 Mar 1;31(3):588\u2013594. https:\/\/doi.org\/10.1158\/1055-9965.EPI-21-0895","DOI":"10.1158\/1055-9965.EPI-21-0895"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Rebolj M, Pesola F, Mathews C, Mesher D, Soldan K, Kitchener H. The impact of catch-up bivalent human papillomavirus vaccination on cervical screening outcomes: An observational study from the English HPV primary screening pilot. Br J Cancer. 2022 Jul 20;127(2):278\u2013287. https:\/\/doi.org\/10.1038\/s41416-022-01791-w","DOI":"10.1038\/s41416-022-01791-w"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Giuliano AR, Botha MH, Zeier M, et al. High HIV, HPV, and STI prevalence among young Western Cape, South African women: EVRI HIV prevention preparedness trial. J Acquir Immune Defic Syndr. 2015 Feb 1;68(2):227\u2013235. https:\/\/doi.org\/10.1097\/QAI.0000000000000425","DOI":"10.1097\/QAI.0000000000000425"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Ebrahim S, Mndende XK, Kharsany ABM, et al. High burden of human papillomavirus (HPV) infection among young women in KwaZulu-Natal, South Africa. PLoS One. 2016 Jan 1;11(1):e0146603. https:\/\/doi.org\/10.1371\/journal.pone.0146603","DOI":"10.1371\/journal.pone.0146603"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Menezes LJ, Pokharel U, Sudenga SL, et al. Patterns of prevalent HPV and STI co-infections and associated factors among HIV-negative young Western Cape, South African women: The EVRI trial. Sex Transm Infect. 2018 Feb 1;94(1):55\u201361. https:\/\/doi.org\/10.1136\/sextrans-2016-053046","DOI":"10.1136\/sextrans-2016-053046"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Mbulawa ZZA, Somdyala NI, Mabunda SA, Williamson AL. High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa. PLoS One. 2021 Jun 18;16(6):e0253074. https:\/\/doi.org\/10.1371\/journal.pone.0253074","DOI":"10.1371\/journal.pone.0253074"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Getahun F, Mazengia F, Abuhay M, Birhanu Z. Comprehensive knowledge about cervical cancer is low among women in Northwest Ethiopia. BMC Cancer. 2013 Dec 2;13(1):2. https:\/\/doi.org\/10.1186\/1471-2407-13-2","DOI":"10.1186\/1471-2407-13-2"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Nyamambi E, Murendo C, Sibanda N, Mazinyane S. Knowledge, attitudes and barriers of cervical cancer screening among women in Chegutu rural district of Zimbabwe. Cogent Soc Sci. 2020 Jan 18;6(1):1766784. https:\/\/doi.org\/10.1080\/23311886.2020.1766784","DOI":"10.1080\/23311886.2020.1766784"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Flood T, Wilson IM, Prue G, McLaughlin M, Hughes CM. Impact of school-based educational interventions in middle adolescent populations (15\u201317yrs) on human papillomavirus (HPV) vaccination uptake and perceptions\/knowledge of HPV and its associated cancers: A systematic review. Prev Med (Baltim). 2020 Oct;139:106168. https:\/\/doi.org\/10.1016\/j.ypmed.2020.106168","DOI":"10.1016\/j.ypmed.2020.106168"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Ducray JF, Kell CM, Basdav J, Haffejee F. Cervical cancer knowledge and screening uptake by marginalized population of women in inner-city Durban, South Africa: Insights into the need for increased health literacy. Women\u2019s Health. 2021;17:17455065211047141. https:\/\/doi.org\/10.1177\/17455065211047141","DOI":"10.1177\/17455065211047141"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Zhang M, Sit JWH, Chan DNS, Akingbade O, Chan CWH. Educational interventions to promote cervical cancer screening among rural populations: A systematic review. Int J Environ Res Public Health. 2022;19(11):6874. https:\/\/doi.org\/10.3390\/ijerph19116874","DOI":"10.3390\/ijerph19116874"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Mupepi SC, Sampselle CM, Johnson TRB. Knowledge, attitudes, and demographic factors influencing cervical cancer screening behavior of Zimbabwean women. J Womens Health. 2011 Jun;20(6):943\u2013952. https:\/\/doi.org\/10.1089\/jwh.2010.2062","DOI":"10.1089\/jwh.2010.2062"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Compaore S, Ouedraogo CMR, Koanda S, Haynatzki G, Chamberlain RM, Soliman AS. Barriers to cervical cancer screening in Burkina Faso: Needs for patient and professional education. J Cancer Educ. 2016 Dec 4;31(4):760\u2013766. https:\/\/doi.org\/10.1007\/s13187-015-0898-9","DOI":"10.1007\/s13187-015-0898-9"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Gwavu Z, Murray D, Okafor UB. Perception of women\u2019s knowledge of and attitudes towards cervical cancer and Papanicolaou smear screenings: A qualitative study in South Africa. 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