{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:59:43Z","timestamp":1785427183975,"version":"3.56.0"},"reference-count":30,"publisher":"AOSIS","issue":"1","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Background:\u00a0Understanding the intersection of epilepsy and pregnancy, including knowledge gaps and healthcare access for women with epilepsy (WWE), is critical. This study evaluated WWE knowledge gaps and information needs concerning epilepsy\u2019s impact on their sexual and reproductive health during pregnancy and examined healthcare system factors affecting their access to information, aiming to identify areas for improvement in educational and healthcare strategies to enhance health management for WWE.\n\nMethods:\u00a0From July 2022 to June 2023, 111 WWE aged 18 to 40 years were recruited from the family medicine and internal medicine outpatient departments at Steve Biko Academic Hospital, Tembisa Tertiary Hospital (TTH), and Kalafong Hospital. Interviews assessed various aspects related to epilepsy in pregnancy and contraceptive use.\n\nResults:\u00a0The study found strong links between WWE, their demographics, and their awareness of pregnancy-related epilepsy issues. Participants from TTH showed notably higher awareness (85.5%) of risks from epilepsy and AED during pregnancy (p\u00a0&lt; 0.05). Age and education significantly influenced pregnancy planning and understanding of medication risks. Younger women (20\u201325 years) were more inclined towards future pregnancies, and those with more education were better informed about medication risks (p\u00a0&lt; 0.05); and 68.5% had received counselling on AED and contraceptive interactions, yet only 16.2% knew AED could reduce contraceptive effectiveness.\n\nConclusion:\u00a0The study reveals significant knowledge gaps in WWE regarding the impact of epilepsy and AED on pregnancy, suggesting tailored educational and counselling initiatives to improve WWE health outcomes and quality of life, advancing chronic disease management and public health objectives.\n\nContribution:\u00a0The study highlights substantial knowledge gaps in epilepsy during pregnancy among WWE, urging tailored counselling and information to empower informed decisions.<\/jats:p>","DOI":"10.4102\/safp.v66i1.5937","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T18:45:51Z","timestamp":1723833951000},"update-policy":"https:\/\/doi.org\/10.4102\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["What do women with epilepsy know about pregnancy?"],"prefix":"10.4102","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1710-9801","authenticated-orcid":false,"given":"Miyalani G.","family":"Baloyi","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00g0p6g84","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Pretoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2506-5087","authenticated-orcid":false,"given":"Rethabile","family":"Khalema","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00g0p6g84","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Pretoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8769-3273","authenticated-orcid":false,"given":"Sumaiya","family":"Adam","sequence":"additional","affiliation":[{"name":"University of Pretoria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2580","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"Fisher RS, Acevedo C, Arzimanoglou A, et al. ILAE official report: A practical clinical definition of epilepsy. Epilepsia. 2014;55(4):475\u2013482. https:\/\/doi.org\/10.1111\/epi.12550","DOI":"10.1111\/epi.12550"},{"key":"ref1","unstructured":"World Health Organization. Neurological disorders: Public health challenges. Geneva: World Health Organization, 2006; p. 1\u201347."},{"key":"ref2","unstructured":"World Health Organization. Atlas: Country resources for neurological disorders [homepage on the Internet]. 2nd ed. Geneva: World Health Organization, 2004 [cited 2024 Apr 24]; p. 1\u201347. Available from: https:\/\/iris.who.int\/bitstream\/handle\/10665\/258947\/9789241565509-eng.pdf?sequence=1"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Ngugi AK, Bottomley C, Kleinschmidt I, et al. Prevalence of active convulsive epilepsy in sub-Saharan Africa and associated risk factors: Cross-sectional and case-control studies. Lancet Neurol. 2013;12(3):253\u2013263. https:\/\/doi.org\/10.1016\/S1474-4422(13)70003-6","DOI":"10.1016\/S1474-4422(13)70003-6"},{"key":"ref4","unstructured":"Gay K. Epilepsy: The ultimate teen guide. Maryland: Rowman & Littlefield; 2017."},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Pallerla S, Narasimha VM, Thomas PT, Raghvendra K. Knowledge, risk perception, and reproductive decision making among women with epilepsy. Int J Epilepsy. 2022;8(1):21\u201327. https:\/\/doi.org\/10.1055\/s-0043-1768584","DOI":"10.1055\/s-0043-1768584"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Long L, McAuley JW, Shneker B, Moore JL. The validity and reliability of the Knowledge of Women\u2019s Issues and Epilepsy (KOWIE) questionnaires I and II. J Neurosci Nurs. 2005;37(2):88\u201391. https:\/\/doi.org\/10.1097\/01376517-200504000-00005","DOI":"10.1097\/01376517-200504000-00005"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Herzog AG, MacEachern DB, Mandle HB, et al. Folic acid use by women with epilepsy: Findings of the Epilepsy birth control registry. Epilepsy Behav. 2017;72:156\u2013160. https:\/\/doi.org\/10.1016\/j.yebeh.2017.05.007","DOI":"10.1016\/j.yebeh.2017.05.007"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Harden CL, Meador KJ, Pennell PB, et al. Practice parameter update: Management issues for women with epilepsy \u2013 Focus on pregnancy (an evidence-based review): Teratogenesis and perinatal outcomes: Report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society. Neurology. 2009;73(2):133\u2013141. https:\/\/doi.org\/10.1212\/WNL.0b013e3181a6b312","DOI":"10.1212\/WNL.0b013e3181a6b312"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Mameniskiene R, Sakalauskaite-Juodeikiene E, Budrys V. People with epilepsy lack knowledge about their disease. Epilepsy Behav. 2015;46:192\u2013197. https:\/\/doi.org\/10.1016\/j.yebeh.2015.03.002","DOI":"10.1016\/j.yebeh.2015.03.002"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Bangar S, Shastri A, El-Sayeh H, Cavanna AE. Women with epilepsy: Clinically relevant issues. Funct Neurol. 2016;31(3):127\u2013134. https:\/\/doi.org\/10.11138\/fneur\/2016.31.3.127","DOI":"10.11138\/FNeur\/2016.31.3.127"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"McGrath A, Sharpe L, Lah S, Parratt K. Pregnancy-related knowledge and information needs of women with epilepsy: A systematic review. 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Epilepsy Behav. 2011;22(2):358\u2013363. https:\/\/doi.org\/10.1016\/j.yebeh.2011.07.009","DOI":"10.1016\/j.yebeh.2011.07.009"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Zupanc ML. Antiepileptic drugs and hormonal contraceptives in adolescent women with epilepsy. Neurology. 2006;66(6 Suppl 3):S37\u2013S45. https:\/\/doi.org\/10.1212\/wnl.66.66_suppl_3.s37","DOI":"10.1212\/WNL.66.66_suppl_3.S37"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Dierking C, Porschen T, Walter U, R\u00f6sche J. Pregnancy related knowledge of women with epilepsy \u2013 An internet-based survey in German-speaking countries. Epilepsy Behav. 2018;79:17\u201322. https:\/\/doi.org\/10.1016\/j.yebeh.2017.11.013","DOI":"10.1016\/j.yebeh.2017.11.013"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Bhakta J, Bainbridge J, Borgelt L. Teratogenic medications and concurrent contraceptive use in women of childbearing ability with epilepsy. 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CNS Drugs. 2002;16(4):263\u2013272. https:\/\/doi.org\/10.2165\/00023210-200216040-00005","DOI":"10.2165\/00023210-200216040-00005"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Chang SI, McAuley JW. Pharmacotherapeutic issues for women of childbearing age with epilepsy. Ann Pharmacother. 1998;32(7\u20138):794\u2013801. https:\/\/doi.org\/10.1345\/aph.17253","DOI":"10.1345\/aph.17253"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Crawford P, Hudson S. Understanding the information needs of women with epilepsy at different lifestages: Results of the \u2018ideal world\u2019 survey. Seizure. 2003;12(7):502\u2013507. https:\/\/doi.org\/10.1016\/s1059-1311(03)00085-2","DOI":"10.1016\/S1059-1311(03)00085-2"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Morrell MJ, Sarto GE, Shafer PO, Borda EA, Herzog A, Callanan M. Health issues for women with epilepsy: A descriptive survey to assess knowledge and awareness among healthcare providers. J Womens Health Gender Based Med. 2000;9(9): 959\u2013965. https:\/\/doi.org\/10.1089\/15246090050199982","DOI":"10.1089\/15246090050199982"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Li Q, Cao Y, Zhang J, et al. Pregnancy-related knowledge in women with epilepsy in childbearing age: A pilot questionnaire survey from China. 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