{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:24:21Z","timestamp":1785403461297,"version":"3.56.0"},"reference-count":22,"publisher":"AOSIS","issue":"1","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Southern African Journal of Infectious Diseases"],"abstract":"<jats:p>Background:\u00a0Candidemia is associated with high morbidity and mortality. The epidemiology of candidemia has changed globally over the past 20 years. South African surveillance demonstrated a shift in epidemiology from\u00a0Candida albicans\u00a0to non-albicans species including\u00a0Candida parapsilosis\u00a0and\u00a0Candida auris. Hospital-level candidemia incidence from South Africa has not been reported previously.Methods:\u00a0We performed a retrospective laboratory-based analysis of blood cultures with confirmed causative agents of candidemia. Ward type, department, gender and admission to critical care units were captured. Data were analysed in Microsoft Excel, Statistical Package for the Social Sciences (SPSS) and Epitools.Results:\u00a0The incidence of candidemia during the study period was 2.87 per 1000 admissions. The total proportion of non-albicans species causing candidemia was 425\/618 (69.7%). Overall, 65.4% of candidemia cases occurred in non-critical care units. There was a significant increase in the proportion of\u00a0C. auris\u00a0isolates between 2016 and 2020 (p\u00a0 0.001). Isolation of\u00a0C. auris\u00a0was associated with admission to critical care units (p\u00a0 0.001, odds ration [OR] 3.856, 95% confidence interval [CI]: 2.360\u20136.300). The proportion of azole-resistant candidemia cases increased from 21\/53 (39.6%) in 2016 to 41\/59 (69.5%) in 2020 (p\u00a0= 0.002).Conclusion:\u00a0The incidence of candidemia remained stable over the five-year study period. However, the proportion of\u00a0C. auris\u00a0isolates increased significantly during the study period as did the overall proportion of azole-resistant candidemia. Antifungal stewardship and continued hospital-level surveillance are imperative.<\/jats:p>","DOI":"10.4102\/sajid.v37i1.326","type":"journal-article","created":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T08:17:39Z","timestamp":1644826659000},"source":"Crossref","is-referenced-by-count":7,"title":["Incidence of candidemia and prevalence of azole-resistant candidemia at a tertiary South African hospital \u2013 A retrospective laboratory analysis 2016\u20132020"],"prefix":"10.4102","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5115-5999","authenticated-orcid":false,"given":"Vindana","family":"Chibabhai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2580","published-online":{"date-parts":[[2022,2,15]]},"reference":[{"key":"ref0001","doi-asserted-by":"publisher","DOI":"10.3390\/jof3040057"},{"key":"ref0002","doi-asserted-by":"publisher","DOI":"10.7196\/SAMJ.2019.v109i11.13718"},{"key":"ref0003","doi-asserted-by":"publisher","DOI":"10.3201\/eid2509.190040"},{"key":"ref0004","author":"Antibiotic resistance is the next great global challenge","year":"2022","journal-title":"Antibiotic resistance is the next great global challenge 2016 \u2013 We must act now [homepage on the Internet]"},{"key":"ref0005","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx444"},{"key":"ref0006","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw091"},{"key":"ref0007","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix131"},{"key":"ref0008","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2013.02.010"},{"key":"ref0009","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000003151"},{"key":"ref0010","doi-asserted-by":"publisher","DOI":"10.3390\/jof6010030"},{"key":"ref0011","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2021.03.007"},{"key":"ref0012","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05947-11"},{"issue":"1","key":"ref0013","first-page":"55","volume":"110","author":"Law","year":"2019","journal-title":"S Afr Med J Suid-Afr Tydskr Vir Geneeskd"},{"key":"ref0014","first-page":"8","volume":"3","author":"Knorring","year":"2019","journal-title":"S Afr J Oncol [serial online]"},{"key":"ref0015","author":"First meeting of the WHO antifungal","year":"2020","journal-title":"First meeting of the WHO antifungal expert group on identifying priority fungal pathogens [homepage on the Internet]"},{"key":"ref0016","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1594"},{"key":"ref0017","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13332"},{"key":"ref0018","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13225"},{"key":"ref0019","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-020-00710-z"},{"key":"ref0020","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2019.06.001"},{"key":"ref0021","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-015-9859-4"},{"key":"ref0022","doi-asserted-by":"publisher","DOI":"10.4103\/npmj.npmj_104_17"}],"container-title":["Southern African Journal of Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/sajid.co.za\/index.php\/sajid\/article\/viewFile\/326\/856","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/sajid.co.za\/index.php\/sajid\/article\/viewFile\/326\/857","content-type":"application\/epub+zip","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/sajid.co.za\/index.php\/sajid\/article\/viewFile\/326\/858","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/sajid.co.za\/index.php\/sajid\/article\/viewFile\/326\/859","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/sajid.co.za\/index.php\/sajid\/article\/viewFile\/326\/859","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T08:41:30Z","timestamp":1648802490000},"score":1,"resource":{"primary":{"URL":"https:\/\/sajid.co.za\/index.php\/sajid\/article\/view\/326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,15]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1,19]]}},"URL":"https:\/\/doi.org\/10.4102\/sajid.v37i1.326","relation":{},"ISSN":["2313-1810","2312-0053"],"issn-type":[{"value":"2313-1810","type":"electronic"},{"value":"2312-0053","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,15]]}}}