{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:34:27Z","timestamp":1785429267275,"version":"3.56.0"},"reference-count":28,"publisher":"AOSIS","issue":"1","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Background:\u00a0While most infections with multidrug-resistant organisms (MDROs) affect colonised people, there is limited evidence on MDRO colonisation in South African dialysis patients.\n\nObjectives:\u00a0This study evaluated the prevalence of MDRO colonisation among dialysis patients, the resistance patterns of each MDRO and the risk factors for colonisation.\n\nMethod:\u00a0Rectal and nasal swabs were collected from dialysis patients who consented to participate in a 5-month study to identify selected MDROs (April 2021 \u2013 August 2021). Specimens were cultured on selected chromogenic media. Data collected included demographics, clinical information from medical records and laboratory results.\n\nResults:\u00a0Multidrug-resistant organisms were isolated from 17 (23.9%) of the 71 enrolled participants. Of the 23 MDRO strains from rectal swabs (n\u00a0= 71), extended-spectrum beta-lactamase-producing Enterobacterales accounted for 21.1% (15\/71), vancomycin-resistant enterococci 2.8% (n\u00a0= 2\/71) and carbapenem-resistant Enterobacterales 4.2% (n\u00a0= 3\/71). Klebsiella pneumoniae (65.2%,\u00a0n\u00a0= 15\/23) was the most prevalent MDRO. More than 80% resistance to trimethoprim and sulfamethoxazole, cefotaxine, and ciprofloxacin was noted. Significant risk factors included previous hospitalisation, proton pump inhibitor use and antibiotic exposure in the past 6 months.\n\nConclusion:\u00a0Multidrug-resistant organisms\u2019 carriage was high in our dialysis population. The infection prevention and control measures need to be revised and strengthened.\n\nContribution:\u00a0This study falls within the scope of the SAJID journal as it is the first within sub-Sahara Africa to report that approximately one-fifth of dialysis patients were colonised with MDRO, which is a significant risk for MDRO infections.<\/jats:p>","DOI":"10.4102\/sajid.v39i1.607","type":"journal-article","created":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T07:28:34Z","timestamp":1720250914000},"update-policy":"https:\/\/doi.org\/10.4102\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Colonisation with multidrug-resistant organisms among dialysis patients at Universitas Academic Hospital"],"prefix":"10.4102","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4497-4266","authenticated-orcid":false,"given":"Godknows","family":"Shamhuyashe","sequence":"first","affiliation":[{"name":"University of the Free State, Bloemfontein, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0861-8264","authenticated-orcid":false,"given":"Nicoline","family":"van Zyl","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/009xwd568","id-type":"ROR","asserted-by":"publisher"}],"name":"University of the Free State"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5092-2957","authenticated-orcid":false,"given":"Cornel","family":"van Rooyen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/009xwd568","id-type":"ROR","asserted-by":"publisher"}],"name":"University of the Free State"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8968-5488","authenticated-orcid":false,"given":"Feziwe","family":"Bisiwe","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/009xwd568","id-type":"ROR","asserted-by":"publisher"}],"name":"University of the Free State"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2559-9596","authenticated-orcid":false,"given":"Jolly","family":"Musoke","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/009xwd568","id-type":"ROR","asserted-by":"publisher"}],"name":"University of the Free State"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2580","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"key":"ref0","unstructured":"World Health Organization. Prioritization of Pathogens to guide discovery, research, and development of new antibiotics for drug-resistant bacterial infections, including tuberculosis [homepage on the Internet]. World Health Organization; 2017 [cited 2022 June 10]; Available from https:\/\/apps.who.int\/iris\/handle\/10665\/311820."},{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Midturi JK, Ranganath S. Prevention and treatment of multidrug-resistant organisms in end-stage renal disease. Adv Chronic Kidney Dis. 2019 Jan; 26(1):51\u201360. https:\/\/doi.org\/10.1053\/j.ackd.2018.09.003","DOI":"10.1053\/j.ackd.2018.09.003"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Collier S, Davenport A. Reducing the risk of infection in end-stage kidney failure patients treated by dialysis. 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JAMA Intern Med. 2020;120:561\u2013571. https:\/\/doi.org\/10.1001\/jamainternmed.2020.0009","DOI":"10.1001\/jamainternmed.2020.0009"}],"container-title":["Southern African Journal of Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/sajid.co.za\/index.php\/sajid\/article\/view\/607\/1528","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:05:46Z","timestamp":1781787946000},"score":1,"resource":{"primary":{"URL":"https:\/\/sajid.co.za\/index.php\/sajid\/article\/view\/607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,9]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1,1]]}},"URL":"https:\/\/doi.org\/10.4102\/sajid.v39i1.607","relation":{},"ISSN":["2312-0053","2313-1810"],"issn-type":[{"value":"2312-0053","type":"print"},{"value":"2313-1810","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,9]]},"article-number":"a607"}}