{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:04:03Z","timestamp":1785431043522,"version":"3.56.0"},"reference-count":29,"publisher":"AOSIS","issue":"1","license":[{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Fungal endocarditis is rare, challenging to diagnose and treat and associated with high mortality. We describe a case of Fusarium solani endocarditis in a patient with Ebstein\u2019s anomaly with a favourable outcome.\n\nContribution: We emphasise that surgical intervention with source control of the infective vegetation is still the mainstay of treatment and highlight the importance of submitting infected source material for histology, culture and molecular testing to identify the causative organism.\n\nKeywords: endocarditis; invasive fungi; Fusarium; fusariosis; Ebstein anomaly.<\/jats:p>","DOI":"10.4102\/sajid.v40i1.699","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T07:58:50Z","timestamp":1739260730000},"update-policy":"https:\/\/doi.org\/10.4102\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Favourable outcome of Fusarium prosthetic valve endocarditis in a patient with an Ebstein anomaly"],"prefix":"10.4102","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8741-4771","authenticated-orcid":false,"given":"Scott G.","family":"Lee-Jones","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05bk57929","id-type":"ROR","asserted-by":"publisher"}],"name":"Stellenbosch University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4876-6104","authenticated-orcid":false,"given":"Stefan","family":"van der Westhuizen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05bk57929","id-type":"ROR","asserted-by":"publisher"}],"name":"Stellenbosch University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5210-9054","authenticated-orcid":false,"given":"Johannes","family":"Taljaard","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05bk57929","id-type":"ROR","asserted-by":"publisher"}],"name":"Stellenbosch University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7869-9462","authenticated-orcid":false,"given":"Nelesh P.","family":"Govender","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03rp50x72","id-type":"ROR","asserted-by":"publisher"}],"name":"University of the Witwatersrand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2981-4724","authenticated-orcid":false,"given":"Rubina","family":"Razack","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05bk57929","id-type":"ROR","asserted-by":"publisher"}],"name":"Stellenbosch University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2580","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"Antinori S, Ferraris L, Orlando G, et al. Fungal endocarditis observed over an 8-year period and a review of the literature. Mycopathologia. 2014;178(1\u20132):37\u201351. https:\/\/doi.org\/10.1007\/s11046-014-9754-4","DOI":"10.1007\/s11046-014-9754-4"},{"key":"ref1","unstructured":"Arriaga J. Ebstein\u2019s anomaly associated with bacterial endocarditis. Rev Invest Clin. 1973;25(4):349\u2013358."},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Batista BG, Chaves MA, Reginatto P, Saraiva OJ, Fuentefria AM. Human fusariosis: An emerging infection that is difficult to treat. Rev Soc Bras Med Trop. 2020;53:e20200013. https:\/\/doi.org\/10.1590\/0037-8682-0013-2020","DOI":"10.1590\/0037-8682-0013-2020"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Bilge AK, Adalet K, Ozyigit T, Ozben B, Yilmaz E. Tricuspid endocarditis in an adult patient with Ebstein\u2019s anomaly who has a residual pacemaker lead. Int J Cardiovasc Imaging. 2005;21(6):641\u2013643. https:\/\/doi.org\/10.1007\/s10554-005-2825-3","DOI":"10.1007\/s10554-005-2825-3"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Camin A-M. Endocarditis due to Fusarium dimerum four years after coronary artery bypass grafting. Clin Infect Dis. 1999;28(1):150. https:\/\/doi.org\/10.1086\/517184","DOI":"10.1086\/517184"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Esnakula AK, Summers I, Naab TJ. Fatal disseminated Fusarium infection in a human immunodeficiency virus positive patient. Case Rep Infect Dis. 2013;2013(1):379320. https:\/\/doi.org\/10.1155\/2013\/379320","DOI":"10.1155\/2013\/379320"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Ghosh S, Phillips A, Ghosh S, Singh A. Native valve endocarditis, fusarium and end-stage renal disease. BMJ Case Rep. 2018;2018:223290. https:\/\/doi.org\/10.1136\/bcr-2017-223290","DOI":"10.1136\/bcr-2017-223290"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Guinvarc\u2019h A, Guilbert L, Marmorat-Khuong A, et al. Disseminated Fusarium solani infection with endocarditis in a lung transplant recipient. Mycoses. 1998;41(1\u20132):59\u201361. https:\/\/doi.org\/10.1111\/j.1439-0507.1998.tb00378.x","DOI":"10.1111\/j.1439-0507.1998.tb00378.x"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Guzman-Cottrill JA, Zheng X, Chadwick EG. Fusarium solani endocarditis successfully treated with liposomal Amphotericin B and Voriconazole. Pediatr Infect Dis J. 2004;23(11):1059\u20131060. https:\/\/doi.org\/10.1097\/01.inf.0000143649.90952.41","DOI":"10.1097\/01.inf.0000143649.90952.41"},{"key":"ref9","unstructured":"Hoenigl M, Salmanton-Garcia J, Walsh TJ, et al. Global guideline for the diagnosis and management of rare mould infections: An initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology and the American Society for Microbiology. Lancet Infect Dis. 2021;21(8):e246\u2013e257."},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Hsu CM, Lee PI, Chen JM, et al. Fatal Fusarium endocarditis complicated by hemolytic anemia and thrombocytopenia in an infant. Pediatr Infect Dis J. 1994;13(12):1146\u20131148. https:\/\/doi.org\/10.1097\/00006454-199412000-00015","DOI":"10.1097\/00006454-199412000-00015"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Inano S, Kimura M, Iida J, Arima N. Combination therapy of voriconazole and terbinafine for disseminated fusariosis: Case report and literature review. J Infect Chemother. 2013;19(6):1173\u20131180. https:\/\/doi.org\/10.1007\/s10156-013-0594-9","DOI":"10.1007\/s10156-013-0594-9"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Izquierdo-Garcia LF, Carmona SL, Zuluaga P, et al. Efficacy of disinfectants against Fusarium oxysporum f. sp. cubense tropical race 4 isolated from La Guajira, Colombia. J Fungi (Basel). 2021;7(4):297. https:\/\/doi.org\/10.3390\/jof7040297","DOI":"10.3390\/jof7040297"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Jorens P, Van Den Heuvel P, Van Cauwelaert P, Parizel G, Mertens A. Fusarium endocarditis involving aortic valve following coronary artery surgery. Eur Heart J. 1990;11(5):476\u2013478. https:\/\/doi.org\/10.1093\/oxfordjournals.eurheartj.a059732","DOI":"10.1093\/oxfordjournals.eurheartj.a059732"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Kassar O, Charfi M, Trabelsi H, Hammami R, Elloumi M. Fusarium solani endocarditis in an acute leukemia patient. Med Mal Infect. 2016;46(1):57\u201359. https:\/\/doi.org\/10.1016\/j.medmal.2015.11.004","DOI":"10.1016\/j.medmal.2015.11.004"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Katiyar SK, Edlind TD. Role for Fks1 in the intrinsic echinocandin resistance of Fusarium solani as evidenced by hybrid expression in Saccharomyces cerevisiae. Antimicrob Agents Chemother. 2009;53(5):1772\u20131778. https:\/\/doi.org\/10.1128\/AAC.00020-09","DOI":"10.1128\/AAC.00020-09"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Li Z, Denning DW. The impact of corticosteroids on the outcome of fungal disease: A systematic review and meta-analysis. Curr Fungal Infect Rep. 2023;17(1):54\u201370. https:\/\/doi.org\/10.1007\/s12281-023-00456-2","DOI":"10.1007\/s12281-023-00456-2"},{"key":"ref17","unstructured":"McGinnis M, Severo L, Kalil R, Falleiro P. Endocarditis caused by Fusarium pallidoroseum. J Mycol Med. 1994;4:45\u201347."},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Moazez C, Zeitjian V, Breburda C, Roy R. A rare manifestation of asymptomatic Ebstein\u2019s anomaly with tricuspid valve endocarditis. Case Rep Cardiol. 2017;2017(1):7630915. https:\/\/doi.org\/10.1155\/2017\/7630915","DOI":"10.1155\/2017\/7630915"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Neumann S, Ruffer A, Sachweh J, et al. Narrative review of Ebstein\u2019s anomaly beyond childhood: Imaging, surgery, and future perspectives. Cardiovasc Diagn Ther. 2021;11(6):1310\u20131323. https:\/\/doi.org\/10.21037\/cdt-20-771","DOI":"10.21037\/cdt-20-771"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Nucci M, Anaissie E. Invasive fusariosis. Clin Microbiol Rev. 2023;36(4):e0015922. https:\/\/doi.org\/10.1128\/cmr.00159-22","DOI":"10.1128\/cmr.00159-22"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Nunes Mdo C, Barbosa FB, Gomes GH, Braulio R, Nicoliello MF, Ferrari TC. Fatal right-sided endocarditis caused by Fusarium in an immunocompromised patient: A case report. Mycoses. 2011;54(5):460\u2013462. https:\/\/doi.org\/10.1111\/j.1439-0507.2010.01891.x","DOI":"10.1111\/j.1439-0507.2010.01891.x"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Pappas PG, Kauffman CA, Andes DR, et al. Clinical practice guideline for the management of Candidiasis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis. 2016;62(4):e1\u2013e50. https:\/\/doi.org\/10.1093\/cid\/civ933","DOI":"10.1093\/cid\/civ933"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Pecoraro AJK, Pienaar C, Herbst PG, et al. Causes of infective endocarditis in the Western Cape, South Africa: A prospective cohort study using a set protocol for organism detection and central decision making by an endocarditis team. BMJ Open. 2021;11(12):e053169. https:\/\/doi.org\/10.1136\/bmjopen-2021-053169","DOI":"10.1136\/bmjopen-2021-053169"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Peinado-Acevedo JS, Ramirez-Sanchez IC. Endocarditis by Fusarium keratoplasticum. Mycopathologia. 2021;186(1):131\u2013133. https:\/\/doi.org\/10.1007\/s11046-020-00502-4","DOI":"10.1007\/s11046-020-00502-4"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Santo KR, Franceschi V, Campos AC, et al. Pacemaker endocarditis caused by Propionibacterium acnes in an adult patient with Ebstein\u2019s anomaly: A report of a rare case. Heart, Lung Circ. 2014;23(10):e222\u2013e225. https:\/\/doi.org\/10.1016\/j.hlc.2014.06.009","DOI":"10.1016\/j.hlc.2014.06.009"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Thompson III GR, Jenks JD, Baddley JW, et al. Fungal endocarditis: Pathophysiology, epidemiology, clinical presentation, diagnosis, and management. Clin Microbiol Rev. 2023;36(3):e0001923. https:\/\/doi.org\/10.1128\/cmr.00019-23","DOI":"10.1128\/cmr.00019-23"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Tupaki-Sreepurna A, Kindo AJ. Fusarium: The versatile pathogen. Indian J Med Microbiol. 2018;36(1):8\u201317. https:\/\/doi.org\/10.4103\/ijmm.IJMM_16_24","DOI":"10.4103\/ijmm.IJMM_16_24"},{"key":"ref28","unstructured":"V\u00e1zquez R, G\u00f3mez J, Jim\u00e9nez P, Sainz I, Manzaneque L. Tricuspid endocarditis and Ebstein\u2019s anomaly in an intravenous drug abuser. 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