{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:16:32Z","timestamp":1785420992573,"version":"3.56.0"},"reference-count":5,"publisher":"AOSIS","issue":"1","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked disorder that increases red blood cell susceptibility to oxidative damage. While haemolysis is common, methaemoglobinaemia is a rare complication. A 39-year-old man developed both conditions, triggered by\u00a0Salmonella typhi\u00a0infection. Diagnosis was supported by Heinz bodies and blister cells on blood smear. Methylene blue and high-dose ascorbic acid were relatively contraindicated because of ongoing haemolysis and renal dysfunction.\nContribution:\u00a0This case highlights the importance of considering methaemoglobinaemia in G6PD deficiency during infections and adapting treatment when standard therapies are unsuitable.<\/jats:p>","DOI":"10.4102\/sajid.v41i1.771","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T08:20:52Z","timestamp":1767946852000},"update-policy":"https:\/\/doi.org\/10.4102\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute G6PD deficiency haemolytic crises with associated methaemoglobinaemia in a patient with typhoid"],"prefix":"10.4102","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2847-3609","authenticated-orcid":false,"given":"Jake P.","family":"Jacob","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04nrs5002","id-type":"ROR","asserted-by":"publisher"}],"name":"Helen Joseph Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2104-7070","authenticated-orcid":false,"given":"Midhun T.","family":"John","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04nrs5002","id-type":"ROR","asserted-by":"publisher"}],"name":"Helen Joseph Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1230-9358","authenticated-orcid":false,"given":"Helen Joseph Hospital","family":"Mensky","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04nrs5002","id-type":"ROR","asserted-by":"publisher"}],"name":"Helen Joseph Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7173-5333","authenticated-orcid":false,"given":"Lior","family":"Chernick","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04nrs5002","id-type":"ROR","asserted-by":"publisher"}],"name":"Helen Joseph Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2580","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"Galatas B, Mabote L, Simone W, et al. Heterogeneity of G6PD deficiency prevalence in Mozambique: A school-based cross-sectional survey in three different regions. Malar J. 2017;16:36. https:\/\/doi.org\/10.1186\/s12936-016-1674-y","DOI":"10.1186\/s12936-016-1674-y"},{"key":"ref1","unstructured":"Ludlow JT, Wilkerson RG, Nappe TM. Methemoglobinemia [homepage on the Internet]. StatPearls; 2023 [cited 2025 Aug 18]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK537317\/"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Crowell SB, Crowell EB, Mathew M. Depression of erythrocyte glucose-6-phosphate dehydrogenase (G6PD) activity in enteric fever. Trans R Soc Trop Med Hyg. 1984;78(2):183\u2013186. https:\/\/doi.org\/10.1016\/0035-9203(84)90273-6","DOI":"10.1016\/0035-9203(84)90273-6"},{"key":"ref3","unstructured":"Tanphaichitr VS, Suvatte V, Mahasandana C, Tuchinda S. Transient, acquired glucose-6-phosphate dehydrogenase deficiency in Thai children with typhoid fever. Southeast Asian J Trop Med Public Health [serial online]. 1982 [cited 2025 Aug 18];13(1):105\u2013109. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/7112210\/"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Khajehdehi P. Transient inhibition of glucose utilization by erythrocytes during the acute stage of typhoid fever. Microbiol Res. 2000;155(1):45\u201347. https:\/\/doi.org\/10.1016\/S0944-5013(00)80021-X","DOI":"10.1016\/S0944-5013(00)80021-X"}],"container-title":["Southern African Journal of Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/sajid.co.za\/index.php\/sajid\/article\/view\/771\/1990","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T08:20:53Z","timestamp":1767946853000},"score":1,"resource":{"primary":{"URL":"https:\/\/sajid.co.za\/index.php\/sajid\/article\/view\/771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,13]]},"references-count":5,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.4102\/sajid.v41i1.771","relation":{},"ISSN":["2312-0053","2313-1810"],"issn-type":[{"value":"2312-0053","type":"print"},{"value":"2313-1810","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,13]]},"article-number":"a771"}}