{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T10:47:56Z","timestamp":1782730076026,"version":"3.54.5"},"reference-count":7,"publisher":"AOSIS","issue":"1","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Mpox is a zoonotic orthopoxvirus infection historically linked to being in endemic regions, travel and close physical contact, including within men who have sex with men (MSM) communities. We report a case of severe mpox in a heterosexual man with advanced human immunodeficiency virus (HIV) disease and no travel history to endemic areas. The patient developed extensive cutaneous disease and transmitted mpox to household contacts, illustrating non-sexual transmission. Management included supportive care and tecovirimat under Section 21 authorisation (a regulatory mechanism in South Africa permitting access to an unregistered medicine) with good clinical response.\nContribution:\u00a0This case highlights the changing epidemiology of mpox, the risk of severe disease in immunocompromised patients, household and non-sexual transmission. We also emphasise the importance of early diagnosis, infection control and antiviral therapy when indicated.<\/jats:p>","DOI":"10.4102\/sajid.v41i1.814","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T10:20:54Z","timestamp":1782728454000},"update-policy":"https:\/\/doi.org\/10.4102\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Severe mpox in an immunocompromised, non-traveller South African male"],"prefix":"10.4102","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8154-7570","authenticated-orcid":false,"given":"Preethi A.","family":"John","sequence":"first","affiliation":[{"name":"Tambo Memorial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4168-3200","authenticated-orcid":false,"given":"Omphemetse","family":"Matikane","sequence":"additional","affiliation":[{"name":"Tambo Memorial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8297-0403","authenticated-orcid":false,"given":"Matilda","family":"Mphahlele","sequence":"additional","affiliation":[{"name":"Tambo Memorial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1516-2487","authenticated-orcid":false,"given":"Barbara B.","family":"Makumbi","sequence":"additional","affiliation":[{"name":"Tambo Memorial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2580","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"Mitj\u00e0 O, Ogoina D, Titanji BK, et al. Monkeypox. Lancet. 2023;401(10370):60\u201374. https:\/\/doi.org\/10.1016\/S0140-6736(22)02075-X","DOI":"10.1016\/S0140-6736(22)02075-X"},{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Rizk JG, Lippi G, Henry BM, Forthal DN, Rizk Y. Prevention and treatment of monkeypox. Drugs. 2022;82(9):957\u2013963. https:\/\/doi.org\/10.1007\/s40265-022-01742-y","DOI":"10.1007\/s40265-022-01742-y"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Altindis M, Puca E, Shapo L. Diagnosis of monkeypox virus \u2013 An overview. Travel Med Infect Dis. 2022;50:102459. https:\/\/doi.org\/10.1016\/j.tmaid.2022.102459","DOI":"10.1016\/j.tmaid.2022.102459"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"El Eid R, Allaw F, Haddad SF, Kanj SS. Human monkeypox: A review of the literature. PLoS Pathog. 2022;18(9):e1010768. https:\/\/doi.org\/10.1371\/journal.ppat.1010768","DOI":"10.1371\/journal.ppat.1010768"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Sam-Agudu NA, Martyn-Dickens C, Ewa AU. A global update of mpox (monkeypox) in children. Curr Opin Pediatr. 2023;35(2):193\u2013200. https:\/\/doi.org\/10.1097\/MOP.0000000000001232","DOI":"10.1097\/MOP.0000000000001232"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Laurenson-Schafer H, Sklenovsk\u00e1 N, Hoxha A, et al. Description of the first global outbreak of mpox: An analysis of global surveillance data. Lancet Glob Health. 2023;11(7):e1012\u2013e1023. https:\/\/doi.org\/10.1016\/S2214-109X(23)00198-5","DOI":"10.1016\/S2214-109X(23)00198-5"},{"key":"ref6","unstructured":"Amer F, Khalil HE"}],"container-title":["Southern African Journal of Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/sajid.co.za\/index.php\/sajid\/article\/view\/814\/2119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T10:21:14Z","timestamp":1782728474000},"score":1,"resource":{"primary":{"URL":"https:\/\/sajid.co.za\/index.php\/sajid\/article\/view\/814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":7,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.4102\/sajid.v41i1.814","relation":{},"ISSN":["2312-0053","2313-1810"],"issn-type":[{"value":"2312-0053","type":"print"},{"value":"2313-1810","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]},"article-number":"a814"}}