{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:53:36Z","timestamp":1785437616263,"version":"3.56.0"},"reference-count":30,"publisher":"AOSIS","issue":"1","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Background:\u00a0Candidozyma auris\u00a0has emerged as a nosocomial pathogen in South Africa, characterised by multidrug resistance and environmental persistence.\nObjectives:\u00a0This study aimed to describe the prevalence, disease patterns, and antifungal susceptibility patterns of\u00a0C. auris\u00a0isolates recovered from public-sector healthcare facilities in the greater Pretoria region from 2021 to 2024.\nMethod:\u00a0A retrospective laboratory-based surveillance study was conducted using data from the National Health Laboratory Service Tshwane Academic Division laboratory. Isolates were classified as invasive or non-invasive based on specimen source. Temporal trends in antifungal minimum inhibitory concentrations (MICs) were analysed using interval-censored regression.\nResults:\u00a0A total of 592\u00a0C. auris\u00a0isolates were identified. Blood cultures were the most frequent specimen source overall, comprising 237 isolates (40.03%). Intravascular catheter tip isolates predominated in 2023 and 2024, with 48 and 72 isolates, respectively. The proportion of invasive isolates declined from 56.8% to 40.8% over the study period. Among tested isolates, fluconazole resistance exceeded 99%. Resistance to amphotericin B and echinocandins was uncommon, with eight total isolates identified. Decreasing MIC trends were observed for amphotericin B (\u03b2 = \u22120.059 per year;\u00a0p\u00a0= 0.012) and micafungin (\u03b2 = \u22120.081 per year;\u00a0p\u00a0= 0.026).\nConclusion:\u00a0Candidozyma auris\u00a0remains established in the public-sector within the greater Pretoria region. There is a shift from invasive bloodstream infections towards non-invasive, device-associated isolates. Fluconazole resistance remained high while amphotericin B and echinocandins retained good\u00a0in vitro\u00a0activity.\nContribution:\u00a0This study contributes to the knowledge of\u00a0C. auris\u00a0in the greater Pretoria region, providing insight into epidemiology and antifungal susceptibility.<\/jats:p>","DOI":"10.4102\/sajid.v41i1.817","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T06:50:17Z","timestamp":1777963817000},"update-policy":"https:\/\/doi.org\/10.4102\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence, pattern of disease and antimicrobial susceptibility of Candidozyma auris in the greater Pretoria region from 2021 to 2024"],"prefix":"10.4102","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3859-2867","authenticated-orcid":false,"given":"Abdullah","family":"Moola","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00g0p6g84","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Pretoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1396-4622","authenticated-orcid":false,"given":"Marko G.","family":"Thom","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00g0p6g84","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Pretoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6883-6779","authenticated-orcid":false,"given":"Jonah M.","family":"Finlay","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00g0p6g84","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Pretoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5549-2987","authenticated-orcid":false,"given":"Roxanne","family":"Rule","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00g0p6g84","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Pretoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2610-0440","authenticated-orcid":false,"given":"Mohamed","family":"Said","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00g0p6g84","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Pretoria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2580","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"Bongomin F, Gago S, Oladele RO, Denning DW. 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