{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:25:32Z","timestamp":1785421532689,"version":"3.56.0"},"reference-count":18,"publisher":"AOSIS","issue":"1","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Bilateral isolated cerebral peduncle infarction is a rare stroke, previously reported only in adults. This report describes a paediatric burns patient with preceding cardiac arrest who developed subtle neurology. Imaging revealed bilateral isolated peduncle infarcts with hypoplasia of the left posterior communicating and vertebral arteries. Despite supportive care, the patient deteriorated and demised. This case highlights the vulnerability of peduncular perforators to haemodynamic instability and emphasises the need for early imaging in the detection of paediatric stroke.\nContribution:\u00a0Isolated bilateral cerebral peduncle infarction is a rare form of stroke, particularly in the paediatric population, and is associated with a poor prognosis. Imaging plays an important role in the early diagnosis of this type of stroke.<\/jats:p>","DOI":"10.4102\/sajr.v30i1.3433","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T08:11:58Z","timestamp":1776067918000},"update-policy":"https:\/\/doi.org\/10.4102\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Bilateral cerebral peduncle infarct in a paediatric intensive care unit patient"],"prefix":"10.4102","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4466-2088","authenticated-orcid":false,"given":"Fatimah","family":"Sheik","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02g48bh60","id-type":"ROR","asserted-by":"publisher"}],"name":"Chris Hani Baragwanath Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5296-4394","authenticated-orcid":false,"given":"Rabia","family":"Abid","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02g48bh60","id-type":"ROR","asserted-by":"publisher"}],"name":"Chris Hani Baragwanath Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2580","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"Kwon N, Choi WI, Kim HS. Isolated bilateral cerebral peduncular infarction manifesting pseudobulbar palsy and quadriparesis: A case report. Brain Neurorehabil. 2020;14(2):e16. https:\/\/doi.org\/10.12786\/bn.2021.14.e16","DOI":"10.12786\/bn.2021.14.e16"},{"key":"ref1","unstructured":"Jones J, Bell D, Sciacca F, et al. Cerebral peduncles [homepage on the Internet]. Radiopaedia.org; c2026 [cited 2026 Jan 24]. Available from: https:\/\/radiopaedia.org\/articles\/5810"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Chen H, Hu Q, Raza HK, et al. An analysis of clinical characteristics of rare bilateral cerebral peduncular infarction. Front Neurol. 2019;10:1107. https:\/\/doi.org\/10.3389\/fneur.2019.01107","DOI":"10.3389\/fneur.2019.01107"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Chen W, Yi T, Chen Y, et al. Assessment of bilateral cerebral peduncular infarction: Magnetic resonance imaging, clinical features, and prognosis. J Neurol Sci. 2015;357(1\u20132):131\u2013135. https:\/\/doi.org\/10.1016\/j.jns.2015.07.016","DOI":"10.1016\/j.jns.2015.07.016"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Zhou C, He Y, Tian X, et al. A case report of isolated bilateral cerebral peduncular infarction. Case Rep Neurol Med. 2017;2017:9845917. https:\/\/doi.org\/10.1155\/2017\/9845917","DOI":"10.1155\/2017\/9845917"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Fu X, Li H, Tian X, Wang W, Liu H. Rare presentation of an isolated bilateral cerebral peduncular infarction: A case report and review of the literature. Medicine (Baltimore). 2019;98(44):e17665. https:\/\/doi.org\/10.1097\/MD.0000000000017665","DOI":"10.1097\/MD.0000000000017665"},{"key":"ref6","unstructured":"Joyce C, Le PH, Peterson DC. Neuroanatomy, cranial nerve 3 (oculomotor) [homepage on the Internet]. [cited 2025 Nov 15]. Treasure Island, FL: StatPearls Publishing; 2025. 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Radiol Res Pract. 2012;2012:258524. https:\/\/doi.org\/10.1155\/2012\/258524","DOI":"10.1155\/2012\/258524"},{"key":"ref10","unstructured":"Ropper AH, Samuels MA, Klein JP. Adams and Victor\u2019s principles of neurology. 11th ed. New York, NY: McGraw-Hill; 2022."},{"key":"ref11","unstructured":"Royal College of Paediatrics and Child Health. Stroke in childhood: Clinical guideline for diagnosis, management and rehabilitation. London: RCPCH; 2017."},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Bhanu SP, Pentyala S, Sankar DK. Incidence of hypoplastic posterior communicating artery and fetal posterior cerebral artery in Andhra population of India: A retrospective 3-Tesla magnetic resonance angiographic study. Anat Cell Biol. 2020;53(3):272\u2013278. https:\/\/doi.org\/10.5115\/acb.20.066","DOI":"10.5115\/acb.20.066"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Chuang YM, Lin CL, Yeh SJ, Tseng YC, Lien LM. Posterior communicating artery hypoplasia as a risk factor for acute ischemic stroke in the absence of carotid artery occlusion. J Clin Neurosci. 2008;15(12):1376\u20131381. https:\/\/doi.org\/10.1016\/j.jocn.2008.01.009","DOI":"10.1016\/j.jocn.2008.02.002"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Vilimas A, Gaigalait\u0117 V, Urbonas M, Jatu\u017eis D. Association of vertebral artery hypoplasia and vertebrobasilar cerebrovascular accident. Medicina (Kaunas). 2022;58(9): 1189. https:\/\/doi.org\/10.3390\/medicina58091189","DOI":"10.3390\/medicina58091189"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Bakalarz M, Ro\u017cniecki JJ, Stasio\u0142ek M. Clinical characteristics of patients with vertebral artery hypoplasia. Int J Environ Res Public Health. 2022;19(15): 9317. https:\/\/doi.org\/10.3390\/ijerph19159317","DOI":"10.3390\/ijerph19159317"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Layegh P, Jarahi L, Hassannejad E, Arab M. The association between vertebral artery hypoplasia and fetal-type variants of the posterior cerebral artery with imaging findings among patients with posterior circulation stroke: A single-center cross-sectional study. Health Sci Rep. 2024;7(2):e1918. https:\/\/doi.org\/10.1002\/hsr2.1918","DOI":"10.1002\/hsr2.1918"},{"key":"ref17","unstructured":"Lui F, Khan Suheb MZ, Patti L. Ischemic stroke [homepage on the Internet]. [cited 2026 Jan 09]. Treasure Island, FL: StatPearls Publishing; 2025. 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