{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:48:45Z","timestamp":1787071725491,"version":"build-2736575974"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p>A 30-year-old male jewellery factory worker accidentally ingested silver potassium cyanide and was brought to the emergency department in a state of shock and profound metabolic acidosis. This patient was managed hypothetically with use of injection thiopentone sodium intravenously until the antidote was received. Cyanide is a highly cytotoxic poison and it rapidly reacts with the trivalent iron of cytochrome oxidase thus paralysing the aerobic respiration. The result is severe lactic acidosis, profound shock, and its fatal outcome. The patient dies of cardio-respiratory arrest secondary to dysfunction of the medullary centres. It is rapidly absorbed, symptoms begin few seconds after exposure and death usually occurs in &lt;30 min. The average lethal dose for potassium cyanide is about 250 mg. We used repeated doses of thiopentone sodium till the antidote kit was finally in our hands, hypothesising that it contains thiol group similar to the antidote thiosulphate. Moreover, it is an anticonvulsant. We were successful in our attempts and the patient survived though the specific antidotes could be administered after about an hour.<\/jats:p>","DOI":"10.4103\/0019-5049.135045","type":"journal-article","created":{"date-parts":[[2014,6,23]],"date-time":"2014-06-23T03:10:45Z","timestamp":1403493045000},"page":"312-314","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["Acute cyanide Intoxication: A rare case of survival"],"prefix":"10.4103","volume":"58","author":[{"given":"Durga","family":"Jethava","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyamvada","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Critical Care, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Kothari","sequence":"additional","affiliation":[{"name":"Department of Critical Care, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puneet","family":"Rijhwani","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Critical Care, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20251205","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1006\/taap.1994.1207","article-title":"Preventionofcyanide induced cytotoxicity by nutrients in isolated rathepatocytes","volume":"128","author":"Niknahad","year":"1994","journal-title":"Toxicol Appl Pharmacol"},{"key":"R3-20251205","first-page":"307","article-title":"Acute cyanide poisoning: Clinical spectrum, diagnosis, and treatment","volume":"47","author":"Borron","year":"1996","journal-title":"Arh Hig Rada Toksikol"},{"key":"R5-20251205","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1757-7241-21-31","article-title":"Inhalation injury: Epidemiology, pathology, treatment strategies","volume":"21","author":"Dries","year":"2013","journal-title":"Scand J Trauma Resusc Emerg Med"},{"key":"R6-20251205","first-page":"179","article-title":"Antidotal treatment of acute cyanide poisoning","volume":"7","author":"Marrs","year":"1988","journal-title":"Adverse Drug React Acute Poisoning Rev"},{"key":"R7-20251205","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1001\/jama.1952.02930190015004","article-title":"Nitrite and thiosulfate therapy in cyanide poisoning","volume":"149","author":"Chen","year":"1952","journal-title":"J Am Med Assoc"},{"key":"R8-20251205","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0736-4679(87)90074-6","article-title":"Hydroxycobalamin\/sodium thiosulfate as a cyanide antidote","volume":"5","author":"Hall","year":"1987","journal-title":"J Emerg Med"},{"key":"R9-20251205","first-page":"193","article-title":"Antidotal treatment of cyanide poisoning","volume":"66","author":"M\u00e9garbane","year":"2003","journal-title":"J Chin Med Assoc"},{"key":"R10-20251205","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0736-4679(94)90359-X","article-title":"Cyanide overdose: Survival with fatal blood concentration without antidotal therapy","volume":"12","author":"Saincher","year":"1994","journal-title":"J Emerg Med"}],"container-title":["Indian Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01762628-201458030-00013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:52:28Z","timestamp":1787068348000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01762628-201458030-00013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.4103\/0019-5049.135045","relation":{},"ISSN":["0019-5049","0976-2817"],"issn-type":[{"value":"0019-5049","type":"print"},{"value":"0976-2817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5]]}}}